Gut Liver.
2013 May;7(3):282-289. 10.5009/gnl.2013.7.3.282.
Gastroprotective Effects of Grape Seed Proanthocyanidin Extracts against Nonsteroid Anti-Inflammatory Drug-Induced Gastric Injury in Rats
- Affiliations
-
- 1Department of Internal Medicine, Catholic Research Institute of Medical Sciences, The Catholic University of Korea College of Medicine, Seoul, Korea. jikim@catholic.ac.kr, min6403@catholic.ac.kr
- 2Department of Physiology, Catholic Research Institute of Medical Sciences, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 3Department of Hospital Pathology, Catholic Research Institute of Medical Sciences, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 4Rheumatism Research Center, Catholic Research Institute of Medical Sciences, The Catholic University of Korea College of Medicine, Seoul, Korea.
- KMID: 1431340
- DOI: http://doi.org/10.5009/gnl.2013.7.3.282
Abstract
- BACKGROUND/AIMS
To investigate the gastroprotective effects of grape seed proanthocyanidin extracts (GSPEs) against nonsteroid anti-inflammatory drug (NSAID)-induced gastric mucosal injury in rats.
METHODS
Sprague-Dawley rats were randomly allocated to the normal control, indomethacin, low-dose GSPE, high-dose GSPE and misoprostol groups. All groups except the normal control group received pretreatment drugs for 6 consecutive days. On the 5th and 6th day, indomethacin was administered orally to all groups except for normal control group. The microscopic features of injury were analyzed. The levels of gastric mucosal glutathione, gastric mucosal prostaglandin E2 (PGE2), and proinflammatory cytokines were investigated.
RESULTS
The total areas of ulceration in the GSPE and misoprostol groups were significantly decreased compared with the indomethacin group (p<0.05). However, a difference in ulcer formation among the drug treatment groups was not observed. Meanwhile, the glutathione levels in the high-dose GSPE group were higher than those of both the indomethacin and misoprostol groups (p<0.05) and were similar to those of the normal control group. Additionally, there was no difference among the groups in the levels of gastric mucosal PGE2 and proinflammatory cytokines.
CONCLUSIONS
High-dose GSPE has a strong protective effect against NSAID-induced gastric mucosal injury, which may be associated with the antioxidant effects of GSPE.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Gastroprotective Effect of Cochinchina momordica Seed Extract in Nonsteroidal Anti-Inflammatory Drug-Induced Acute Gastric Damage in a Rat Model
- The Effect of Isoflavone and/or Grape Seed Oil Supplementation on Blood Lipid Profiles and Bone Strength in Ovariectomized Female Rats
- Grape extracts suppress the formation of preneoplastic foci and activity of fatty acid synthase in rat liver
- Suppression of oxidative stress by grape seed supplementation in rats
- The Role of Neutrophil on Nonsteroidal Anti-Inflammatory Drugs Induced Acute Gastric Mucosal Injury
