J Korean Assoc Oral Maxillofac Surg.  2013 Apr;39(2):55-62. 10.5125/jkaoms.2013.39.2.55.

Modulation of osteoblastic/odontoblastic differentiation of adult mesenchymal stem cells through gene introduction: a brief review

Affiliations
  • 1Division of Oral and Maxillofacial Surgery, Department of Dentistry, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
  • 2Department of Oral and Maxillofacial Surgery, Ewha Womans University Mok-dong Hospital, Ewha Womans University School of Medicine, Seoul, Korea. sjsj7777@ewha.ac.kr

Abstract

Bone tissue engineering is one of the important therapeutic approaches to the regeneration of bones in the entire field of regeneration medicine. Mesenchymal stem cells (MSCs) are actively discussed as material for bone tissue engineering due to their ability to differentiate into autologous bone. MSCs are able to differentiate into different lineages: osteo/odontogenic, adipogenic, and neurogenic. The tissue of origin for MSCs defines them as bone marrow-derived stem cells, adipose tissue-derived stem cells, and, among many others, dental stem cells. According to the tissue of origin, DSCs are further stratified into dental pulp stem cells, periodontal ligament stem cells, stem cells from apical papilla, stem cells from human exfoliated deciduous teeth, dental follicle precursor cells, and dental papilla cells. There are numerous in vitro/in vivo reports suggesting successful mineralization potential or osteo/odontogenic ability of MSCs. Still, there is further need for the optimization of MSCs-based tissue engineering methods, and the introduction of genes related to osteo/odontogenic differentiation into MSCs might aid in the process. In this review, articles that reported enhanced osteo/odontogenic differentiation with gene introduction into MSCs will be discussed to provide a background for successful bone tissue engineering using MSCs with artificially introduced genes.

Keyword

Mesenchymal stromal cells; Cell differentiation; Osteoblasts; Odontoblasts; Genes; Transfection

MeSH Terms

Adult
Bone and Bones
Cell Differentiation
Dental Papilla
Dental Pulp
Dental Sac
Humans
Mesenchymal Stromal Cells
Odontoblasts
Osteoblasts
Periodontal Ligament
Regeneration
Stem Cells
Tissue Engineering
Tooth, Deciduous
Transfection
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