- The Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Pathway in Osteoblasts
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Greenblatt MB, Shim JH, Bok S, Kim JM
- KMID: 2527582
- J Bone Metab.
- 2022 Feb;29(1):1-15.
- doi: 10.11005/jbm.2022.29.1.1
Extracellular signal-regulated kinases (ERKs) are evolutionarily ancient signal transducers of the mitogen-activated protein kinase (MAPK) family that have long been linked to the regulation of osteoblast differentiation and bone formation.... -
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- Biocompatibility and Bioactivity of Four Different Root Canal Sealers in Osteoblastic Cell Line MC3T3-El
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Jun NR, Lee SK, Lee SI
- KMID: 2523651
- J Dent Hyg Sci.
- 2021 Dec;21(4):243-250.
- doi: 10.17135/jdhs.2021.21.4.243
Background: Endodontic sealers or their toxic components may become inflamed and lead to delayed wound healing when in direct contact with periapical tissues over an extended period. Moreover, an overfilled... -
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- Spironolactone Attenuates Methylglyoxal-induced Cellular Dysfunction in MC3T3-E1 Osteoblastic Cells
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Park SY, Suh KS, Jung WW, Chin SO
- KMID: 2520778
- J Korean Med Sci.
- 2021 Oct;36(38):e265.
- doi: 10.3346/jkms.2021.36.e265
Background Methylglyoxal (MG) is associated with the pathogenesis of age- and diabetes-related complications. Spironolactone is a competitive antagonist of aldosterone that is widely employed in the treatment of hypertension and heart... -
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- Effects of Advanced Glycation End Products on Differentiation and Function of Osteoblasts and Osteoclasts
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Park SY, Choi KH, Jun JE, Chung HY
- KMID: 2520365
- J Korean Med Sci.
- 2021 Sep;36(37):e239.
- doi: 10.3346/jkms.2021.36.e239
Background: Risk of fragility fractures increases in patients with diabetes mellitus, independent of bone mineral density. In the present study, the effects of advanced glycation end products (AGEs) on differentiation... -
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- Anti-Müllerian Hormone Negatively Regulates Osteoclast Differentiation by Suppressing the Receptor Activator of Nuclear Factor-κB Ligand Pathway
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Kim JH, Yang YR, Kwon KS, Kim N
- KMID: 2520183
- J Bone Metab.
- 2021 Aug;28(3):223-230.
- doi: 10.11005/jbm.2021.28.3.223
Background: Multiple members of the transforming growth factor-β (TGF-β) superfamily have well-established roles in bone homeostasis. Anti-Müllerian hormone (AMH) is a member of TGF-β superfamily of glycoproteins that is responsible... -
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- Effect of TNF-α and IL-6 on Compact Bone-Derived Cells
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Zhang Y, Li X, Chihara T, Dong H, Kagami H
- KMID: 2516530
- Tissue Eng Regen Med.
- 2021 Jun;18(3):441-451.
- doi: 10.1007/s13770-021-00336-1
Background: Although bone tissue engineering has already been applied clinically, its regeneration efficacy is not always sufficient. Local inflammatory cytokines are considered as the major factors that induce apoptosis of transplanted... -
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- Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis
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Khalmuratova R, Shin HW
- KMID: 2512880
- Clin Exp Otorhinolaryngol.
- 2021 Feb;14(1):43-49.
- doi: 10.21053/ceo.2020.00416
Chronic rhinosinusitis (CRS) is a multifactorial and highly heterogeneous upper airway disease that affects approximately 12% of the general population. There is increasing evidence supporting the impact of osteitis on... -
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- High concentration of calcium represses osteoblast differentiation in C2C12 cells
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Lee YJ, Han Y
- KMID: 2510196
- Int J Oral Biol.
- 2020 Dec;45(4):162-168.
- doi: 10.11620/IJOB.2020.45.4.162
Calcium is the most abundant stored mineral in the human body and is especially vital for bone health; thus, calcium deficiency can cause bone-related diseases, such as osteopenia and osteoporosis.... -
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- Osteoblast-Based Therapy—A New Approach for Bone Repair in Osteoporosis: Pre-Clinical Setting
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Mahmoud NS, Mohamed MR, Ali MAM, Aglan HA, Amr KS, Ahmed HH
- KMID: 2502560
- Tissue Eng Regen Med.
- 2020 Jun;17(3):363-373.
- doi: 10.1007/s13770-020-00249-5
BACKGROUND: Osteoporosis is a metabolic bone disease characterized by low bone density resulting in increased fracture susceptibility. This research was constructed to uncover the potential therapeutic application of osteoblasts transplantation,... -
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- Bone Cell Communication Factors Provide a New Therapeutic Strategy for Osteoporosis
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Kim JH, Kim N
- KMID: 2500831
- Chonnam Med J.
- 2020 May;56(2):94-98.
- doi: 10.4068/cmj.2020.56.2.94
Bone homeostasis is strictly regulated by the balance between bone resorption by osteoclasts and bone formation by osteoblasts. Many studies have shown that osteoclasts affect osteoblasts, and vice versa, through... -
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- Freeze-Dried Platelet-Rich Plasma Induces Osteoblast Proliferation via Platelet-Derived Growth Factor Receptor-Mediated Signal Transduction
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Kinoshita , Orita S, Inage K, Fujimoto K, Shiga Y, Abe K, Inoue M, Norimoto M, Umimura T, Ishii T, Yonemoto T, Kamoda H, Tsukanishi T, Suzuki M, Hirosawa N, Akazawa T, Ohtori S
- KMID: 2501180
- Asian Spine J.
- 2020 Jan;14(1):1-8.
- doi: 10.31616/asj.2019.0048
Study Design: Controlled laboratory study. Purpose: This study aimed to evaluate the in vitro pharmacological activity of growth factors (GFs) in freeze-dried platelet-rich plasma (FD-PRP) after storage for 4 weeks. Overview of... -
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- An overview of the endocrine functions of osteocalcin
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Baek K
- KMID: 2470709
- Int J Oral Biol.
- 2019 Dec;44(4):125-129.
- doi: 10.11620/IJOB.2019.44.4.125
Osteocalcin is the most abundant non-collagenous protein produced in bone. It has traditionally been regarded as a marker of bone turnover and is thought to act in the bone matrix... -
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- Conditioned Medium Enhances Osteogenic Differentiation of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells
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Zhong S, He X, Li Y, Lou X
- KMID: 2449245
- Tissue Eng Regen Med.
- 2019 Apr;16(2):141-150.
- doi: 10.1007/s13770-018-0173-3
BACKGROUND: Recent studies have shown that induced pluripotent stem cells (iPSCs) could be differentiated into mesenchymal stem cells (MSCs) with notable advantages over iPSCs per se. In order to promote... -
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- Remifentanil promotes osteoblastogenesis by upregulating Runx2/osterix expression in preosteoblastic C2C12 cells
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Yoon JY, Kim TS, Ahn JH, Yoon JU, Kim HJ, Kim EJ
- KMID: 2444753
- J Dent Anesth Pain Med.
- 2019 Apr;19(2):91-99.
- doi: 10.17245/jdapm.2019.19.2.91
BACKGROUND: The imbalance between osteoblasts and osteoclasts can lead to pathological conditions such as osteoporosis. It has been reported that opioid adversely affect the skeletal system, but it is inconsistent.... -
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- Combined effect of recombinant human bone morphogenetic protein-2 and low level laser irradiation on bisphosphonate-treated osteoblasts
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Jeong SY, Hong JU, Song JM, Kim IR, Park BS, Kim CH, Shin SH
- KMID: 2467172
- J Korean Assoc Oral Maxillofac Surg.
- 2018 Dec;44(6):259-268.
- doi: 10.5125/jkaoms.2018.44.6.259
OBJECTIVES: The purpose of this study was to evaluate the synergic effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) and low-level laser therapy (LLLT) on bisphosphonate-treated osteoblasts. MATERIALS AND METHODS: Human... -
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- Causal Inference Network of Genes Related with Bone Metastasis of Breast Cancer and Osteoblasts Using Causal Bayesian Networks
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Park SB, Chung CK, Gonzalez E, Yoo C
- KMID: 2427991
- J Bone Metab.
- 2018 Nov;25(4):251-266.
- doi: 10.11005/jbm.2018.25.4.251
BACKGROUND: The causal networks among genes that are commonly expressed in osteoblasts and during bone metastasis (BM) of breast cancer (BC) are not well understood. Here, we developed a machine... -
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- Regulation of Osteoblast Metabolism by Wnt Signaling
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Moorer MC, Riddle RC
- KMID: 2447021
- Endocrinol Metab.
- 2018 Sep;33(3):318-330.
- doi: 10.3803/EnM.2018.33.3.318
Wnt/β-catenin signaling plays a critical role in the achievement of peak bone mass, affecting the commitment of mesenchymal progenitors to the osteoblast lineage and the anabolic capacity of osteoblasts depositing... -
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- Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis
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Kwon OC, Kim S, Hong S, Lee CK, Yoo B, Chang EJ, Kim YG
- KMID: 2414554
- Immune Netw.
- 2018 Jun;18(3):e20.
- doi: 10.4110/in.2018.18.e20
IL-32 acts as a pro-inflammatory cytokine by inducing the synthesis of inflammatory molecules as well as promoting the morphological changes involved in the transformation of monocytes into osteoclasts (OCs). Evaluation... -
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- Predicting the Role of Osteal Macrophages and Osteocytes in Bone Tissue Network Using a Mathematical Modeling
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Hwang SJ
- KMID: 2411445
- J Dent Hyg Sci.
- 2018 Apr;18(2):130-135.
- doi: 10.17135/jdhs.2018.18.2.130
The aim of this study was to investigate the role of osteal macrophages (osteomac) and osteocytes in bone remodeling using a mathematical model. We constructed the bone system with pre-osteoblasts,... -
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- The Effect of Antidepressants on Mesenchymal Stem Cell Differentiation
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Kruk JS, Bermeo S, Skarratt K, Fuller SJ, Duque G
- KMID: 2406238
- J Bone Metab.
- 2018 Feb;25(1):43-51.
- doi: 10.11005/jbm.2018.25.1.43
BACKGROUND: Use of antidepressant medications has been linked to detrimental impacts on bone mineral density and osteoporosis; however, the cellular basis behind these observations remains poorly understood. The effect does... -
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