Chonnam Med J.  2022 Jan;58(1):6-12. 10.4068/cmj.2022.58.1.6.

The Role of Histone Acetylation in Mesenchymal Stem Cell Differentiation

• Jang S
• Hwang J
• Jeong HS

• KMID: 2525152
• DOI: http://doi.org/10.4068/cmj.2022.58.1.6

Abstract

The mechanism and action concerning epigenetic modifications, especially that of histone modifications, are not fully understood. However, it is clear that histone modifications play an essential role in several biological processes that are involved in cell proliferation and differentiation. In this article, we focused on how histone acetylation may result in differentiation into mesenchymal stem cells as well as histone acetylation function. Moreover, histone acetylation followed by the action of histone deacetylase inhibitors, which can result in the differentiation of stem cells into other types of cells such as adipocytes, chondrocytes, osteocytes, neurons, and other lineages, were also reviewed.

Keyword

Mesenchymal Stem Cell; Cell Differentiation; Histone Acetylation; Epigenesis; Genetic