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Upregulation of VEGF and FGF2 in Normal Rat Brain after Experimental Intraoperative Radiation Therapy

Kim JH, Chung YG, Kim CY, Kim HK, Lee HK

The expression of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF)2 in the irradiated brain was examined to test how a single high dose radiation, similar to that...
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Differential Expression of Stem Cell Markers and Vascular Endothelial Growth Factor in Human Retinoblastoma Tissue

Kim M, Kim JH, Kim JH, Kim DH, Yu YS

PURPOSE: To investigate the relationship between vascular endothelial growth factor (VEGF) and the cancer stem cell-vascular niche complex in human retinoblastoma tissue. METHODS: Six human retinoblastoma specimens primarily enucleated for...
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Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid

Han S, Huh J, Kim W, Jeong S, Min DS, Jung Y

Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Therefore, PLD is...
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The Prognostic Effect of VEGF Expression in Squamous Cell Carcinoma of the Cervix Treated with Radiation Therapy Alone

Kang JO, Hong SE

We investigated the relationship between vascular endothelial growth factor (VEGF) expression and clinical outcome in squamous cell carcinoma of the cervix treated with radiotherapy alone. The immunohistochemical study was performed...
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Cyclooxygenase-2 and vascular endothelial growth factor in chronic hepatitis, cirrhosis and hepatocellular carcinoma

Kwon SH, Jeong SW, Jang JY, Lee JE, Lee SH, Kim SG, Kim YS, Cho YD, Kim HS, Kim BS, Jin SY

BACKGROUND/AIMS: Cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) are up-regulated in hepatocellular carcinoma (HCC). To investigate the levels of COX-2 and VEGF expression in chronic hepatitis (CH), cirrhosis, and...
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Vascular Endothelial Growth Factor Levels in Ascites Between Chemonaive and Chemotreated Patients

Lee HK, Chae HS, Kim JS, Kim HK, Cho YS, Rho SY, Kang JH, Cho SG, Jang HS, Han K

PURPOSE: Vascular endothelial growth factor (VEGF) levels in malignant ascites have high diagnostic value for their discrimination from asictes of non-malignant origin. However, there have been no reports on the...
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Increased Expression of EMMPRIN and VEGF in the Rat Brain after Gamma Irradiation

Wei M, Li H, Huang H, Xu D, Zhi D, Liu D, Zhang Y

The extracellular matrix metalloproteinase inducer (EMMPRIN) has been known to play a key regulatory role in pathological angiogenesis. A elevated activation of vascular endothelial growth factor (VEGF) following radiation injury...
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Effect of Intravitreal Bevacizumab on Vascular Endothelial Growth Factor Expression in Patients with Proliferative Diabetic Retinopathy

Chung EJ, Kang SJ, Koo JS, Choi YJ, Grossniklaus HE, Koh HJ

PURPOSE: To investigate the effect of bevacizumab (Avastin; Genentech, San Francisco, CA, USA) on vascular endothelial growth factor (VEGF) expression and inflammation in fibrovascular membranes in patients with proliferative diabetic...
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VEGF as a Predictor for Response to Definitive Chemoradiotherapy and COX-2 as a Prognosticator for Survival in Esophageal Squamous Cell Carcinoma

Yoon MS, Nam TK, Lee JS, Cho SH, Song JY, Ahn SJ, Chung IJ, Jeong JU, Chung WK, Nah BS

We investigated the patterns of pretreatment expression of the epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and cyclooxygenase-2 (COX-2) by immunohistochemical staining and determined their correlation with...
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Increased Expression of Cathelicidin by Direct Activation of Protease-Activated Receptor 2: Possible Implications on the Pathogenesis of Rosacea

Kim JY, Kim YJ, Lim BJ, Sohn HJ, Shin D, Oh SH

PURPOSE: Recent findings of increased cathelicidin protein and its proteolytic fragments in rosacea suggest a pathogenic role for cathelicidin in this disease. The relationship between cathelicidin and protease-activated receptor 2...
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Prognostic Value of VEGF in Human Pancreatic Ductal Adenocarcinoma

Lim YJ, Lee JK, Park CK, Song SY, Jang WY, Ha HY, Park DI, Lee KT, Paik SW, Yoo BC, Rhee JC

  • KMID: 759678
  • Korean J Intern Med.
  • 2004 Mar;19(1):10-14.
BACKGROUND: Since pancreatic cancer metastasizes early regardless of the size of the primary tumor, it is suggested that angiogenic factor is upregulated in this disease. Among the angiogenic factors, vascular...
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The Relationship between HIF-2α and VEGF with Radiographic Severity in the Primary Osteoarthritic Knee

Jian-lin Z, Hong-song , Hao P, Shuang D, Shen C, Jian-ping , Bo Q, Jin-qing W, Feng L

PURPOSE: The aim of this study was to determine the relationship of hypoxia-inducible factor-2 (HIF-2α) and vascular endothelial growth factor (VEGF) with radiographic severity in primary osteoarthritis (OA) of the...
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Apparent Diffusion Coefficient Value of Diffusion-Weighted Imaging for Hepatocellular Carcinoma: Correlation with the Histologic Differentiation and the Expression of Vascular Endothelial Growth Factor

Heo SH, Jeong YY, Shin SS, Kim JW, Lim HS, Lee JH, Koh YS, Cho CK, Kang HK

OBJECTIVE: To evaluate whether the histopathological differentiation and the expression of vascular endothelial growth factor (VEGF) of hepatocellular carcinoma (HCC) do show correlation with the apparent diffusion coefficient (ADC) value...
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Mesenchymal Stem Cells Improve Wound Healing In Vivo via Early Activation of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor

Kim CH, Lee JH, Won JH, Cho MK

We investigated the effects of mesenchymal stem cells (MSCs) on wound healing using a three-dimensional (3D) collagen gel scaffold. Three circular full-thickness skin defects were created on the back of...
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Effects of Autologous Platelet-Rich Plasma on Regeneration of Damaged Endometrium in Female Rats

Jang HY, Myoung SM, Choe JM, Kim T, Cheon YP, Kim YM, Park H

PURPOSE: To investigate whether autologous platelet-rich plasma (PRP) treatment can improve regeneration of the endometrium in an experimental model of ethanol-induced damage. MATERIALS AND METHODS: Sixty female Sprague-Dawley rats were randomly...
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Hypoxic Regulation of VEGF, HIF-1 (alpha) in Coronary Collaterals Development

Sung KC, Kim KS, Lee S

BACKGROUND: The interindividual variability for the development of collaterals in coronary artery disease is dependent on the hypoxic induction level of VEGF. To determine whether the hypoxic induction of VEGF...
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