- Involvement of Up-regulation of Death Receptors and Bim in Hispolon-mediated TNF-related Apoptosis-inducing Ligand Sensitization in Human Renal Carcinoma
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Yun JM, Min KJ, Kwon TK
- KMID: 2468797
- J Cancer Prev.
- 2019 Sep;24(3):155-162.
- doi: 10.15430/JCP.2019.24.3.155
BACKGROUND: Hispolon has been shown to possess antitumor effects in various cancer cells. However, the underlying mechanisms are not fully understood. In this study, we evaluated the sensitizing effect of... -
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- Hydrogen Peroxide Upregulates TNF-Related Apoptosis-Inducing Ligand (TRAIL) Expression in Human Astroglial Cells, and Augments Apoptosis of T Cells
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Kwon D, Choi IH
- KMID: 1779506
- Yonsei Med J.
- 2006 Aug;47(4):551-557.
- doi: 10.3349/ymj.2006.47.4.551
The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing... -
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- Expression of TRAIL Receptors in Cervical Cancer
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Chang SJ, Ryu HS, Kim MS, Joo HJ, Chang KH, Oh KS
- KMID: 2083747
- Korean J Gynecol Oncol Colposc.
- 2000 Mar;11(1):45-54.
Apoptosis is an intrinsic and fundamental biological process that plays a critical role in the normal development of multicellular organisms and in maintaining tissue homeostasis. Some of the well known... -
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- Expression of TRAIL (Apo-2L)/TRAIL Receptor System Related to Apoptosis at the Human Extraembryonic Tissues and Gestational Trophoblastic Disease
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Chung IB, Cha DS, Sohn JH, Choi SJ, Han KH
- KMID: 2272186
- Korean J Obstet Gynecol.
- 2003 Nov;46(11):2156-2161.
Human uterus has been known as a immune privileged site for the product of conception. At the feto-maternal interface, Fas system is a underlying main mechanism of maternal immune acceptance.... -
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- Human Brain Astrocytes Mediate TRAIL-mediated Apoptosis after Treatment with IFN-gamma
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Lee J, Shin JS, Choi IH
- KMID: 1715853
- Yonsei Med J.
- 2006 Jun;47(3):354-358.
- doi: 10.3349/ymj.2006.47.3.354
TNF-related apoptosis inducing ligand (TRAIL) expressions were studied in primary human brain astrocytes in response to pro-inflammatory cytokines. When astrocytes were treated with IL-1beta TNF-alphaor IFN-gamma TRAIL was induced in... -
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- Apoptosis and upregulation of TNF-alpha and TRAIL receptor 1 (DR4) in the pathogenesis of food protein-induced enterocolitis syndrome
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Hwang JB, Kim SP, Kang YN, Lee SR, Suh SI, Kwon TK
- KMID: 2073578
- Korean J Pediatr.
- 2010 Apr;53(4):525-531.
- doi: 10.3345/kjp.2010.53.4.525
PURPOSE: Expression levels of tumor necrosis factor (TNF)-alpha expression on the mucosa of the small intestine is increased in patients with villous atrophy in food protein-induced enterocolitis syndrome (FPIES). TNF-alpha... -
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- Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation
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Moon MH, Jeong JK, Seo JS, Seol JW, Lee YJ, Xue M, Jackson CJ, Park SY
- KMID: 1109402
- Exp Mol Med.
- 2011 Mar;43(3):138-145.
- doi: 10.3858/emm.2011.43.3.016
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily of cytokines, is one of the most promising candidates for cancer therapeutics. However, many osteosarcomas are resistant... -
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- Isoproterenol Enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis in Human Embryonic Kidney Cells through Death Receptor 5 up-Regulation
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Eom YW, Jung HY, Oh JE, Lee JW, Ahn MS, Youn YJ, Ahn SG, Kim JY, Lee SH, Yoon J, Yoo BS
- KMID: 2223774
- Korean Circ J.
- 2016 Jan;46(1):93-98.
- doi: 10.4070/kcj.2016.46.1.93
BACKGROUND AND OBJECTIVES: Chronic impairment of beta-adrenergic receptor signaling increases cardiac apoptosis, hypertrophy and fibrosis. The aim of this study was to investigate whether isoproterenol (ISO), an agonist of the... -
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- The Synergistic Apoptotic Interaction of Indole-3-Carbinol and Genistein with TRAIL on Endometrial Cancer Cells
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Parajuli B, Shin SJ, Kwon SH, Cha SD, Lee HG, Bae I, Cho CH
- KMID: 1786959
- J Korean Med Sci.
- 2013 Apr;28(4):527-533.
- doi: 10.3346/jkms.2013.28.4.527
Induction of apoptosis in target cells is a key mechanism by which chemotherapy promotes cell killing. The purpose of this study was to determine whether Indole-3-Carbinol (I3C) and Genistein in... -
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- Up-regulation of the DR5 Expression by Proteasome Inhibitor MG132 Augments TRAIL-Induced Apoptosis in Soft Tissue Sarcoma Cell Lines
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Cheong HJ, Lee KS, Woo IS, Won JH, Byun JH
- KMID: 2167538
- Cancer Res Treat.
- 2011 Jun;43(2):124-130.
PURPOSE: Current chemotherapeutics for treating locally advanced or metastatic soft tissue sarcomas (STS) are limited. Accordingly, the present in vitro study was conducted to evaluate the effects of treatment of... -
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- Anti-inflammatory Activity of Sambucus Plant Bioactive Compounds against TNF-α and TRAIL as Solution to Overcome Inflammation Associated Diseases: The Insight from Bioinformatics Study
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Putra WE, Ode Salma , Rifa'i M
- KMID: 2459962
- Nat Prod Sci.
- 2019 Sep;25(3):215-221.
- doi: 10.20307/nps.2019.25.3.215
Inflammation is the crucial biological process of immune system which acts as body's defense and protective response against the injuries or infection. However, the systemic inflammation devotes the adverse effects... -
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- Cytotoxic Effects of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)and its Molecular Mechanism in Human Gastric Cancer Cells
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Kim JH, Nam SY, Lee BL
- KMID: 2092891
- Korean J Anat.
- 2007 Mar;40(1):69-76.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)induces apoptosis in some cancer cells such as breast,prostate,lung,and colon cancer cells,but not normal cells.However,because the effects of TRAIL in gastric cancer cells is unclear,we... -
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- Tunicamycin enhances TRAIL-induced apoptosis by inhibition of cyclin D1 and the subsequent downregulation of survivin
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Zhang HY, Du ZX, Liu BQ, Gao YY, Meng X, Guan Y, Deng WW, Wang HQ
- KMID: 1123811
- Exp Mol Med.
- 2009 May;41(5):362-369.
- doi: 10.3858/emm.2009.41.5.041
TNF-related apoptosis-inducing ligand (TRAIL) has been proposed as a promising cancer therapy that preferentially induces apoptosis in cancer cells, but not most normal tissues. However, many cancers are resistant to... -
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- The mRNA Expression of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) and Its Receptors in Hepatocellular Carcinoma and Surrounding Liver Tissues
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Jung S, Lee HC, Song HG, Chung YH, Lee YS, Yoon GS, Yu E, Suh DJ
- KMID: 1890003
- Korean J Hepatol.
- 2001 Sep;7(3):273-280.
BACKGROUND/AIMS: TRAIL-induced apoptosis was believed to occur in tumor cell lines, while not in normal cells, which suggested that TRAIL might be safe as an antitumor therapy. Some authors advocate... -
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- Paxilline enhances TRAIL-mediated apoptosis of glioma cells via modulation of c-FLIP, survivin and DR5
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Kang YJ, Kim IY, Kim EH, Yoon MJ, Kim SU, Kwon TK, Choi KS
- KMID: 991620
- Exp Mol Med.
- 2011 Jan;43(1):24-34.
- doi: 10.3858/emm.2011.43.1.003
Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) induces apoptosis selectively in cancer cells while sparing normal cells. However, many cancer cells are resistant to TRAIL-induced cell death. Here, we report that... -
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- The biological complexity of RKIP signaling in human cancers
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Farooqi AA, Li Y, Sarkar FH
- KMID: 2155439
- Exp Mol Med.
- 2015 Sep;47(9):e185.
- doi: 10.1038/emm.2015.70
The Raf kinase inhibitory protein (RKIP) has been demonstrated to modulate different intracellular signaling pathways in cancers. Studies have shown that RKIP is frequently downregulated in cancers; therefore, attempts have... -
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- The Combination of TRAIL Treatment and Cancer Cell Selective Expression of TRAIL-Death Receptor DR4 Induces Cell Death in TRAIL-Resistant Cancer Cells
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Choi E, Kim Y, Kim K
- KMID: 1715873
- Yonsei Med J.
- 2006 Feb;47(1):55-62.
- doi: 10.3349/ymj.2006.47.1.55
The human telomerase reverse transcriptase (hTERT) promoter can be used for the tumor-specific expression of transgenes in order to induce selective cancer cell death. The hTERT core promoter is active... -
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- Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder
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Barbosa IG, Vaz GN, Rocha NP, Machado-Vieira R, Ventura MR, Huguet RB, Bauer ME, Berk M, Teixeira A
- KMID: 2388274
- Clin Psychopharmacol Neurosci.
- 2017 Aug;15(3):269-275.
- doi: 10.9758/cpn.2017.15.3.269
OBJECTIVE: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor... -
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- Long Term Effect of High Glucose and Phosphate Levels on the OPG/RANK/RANKL/TRAIL System in the Progression of Vascular Calcification in rat Aortic Smooth Muscle Cells
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Kang YH, Jin JS, Son SM
- KMID: 2285562
- Korean J Physiol Pharmacol.
- 2015 Mar;19(2):111-118.
- doi: 10.4196/kjpp.2015.19.2.111
Osteoprotegerin (OPG), receptor activator of NF-kappaB ligand (RANKL)/receptor activator of NF-kappaB (RANK) axis, and TNF-related apoptosis-inducing ligand (TRAIL) participate in vascular calcification process including atherosclerosis, but their contributions under high... -
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- Stem Cell Implants for Cancer Therapy: TRAIL-Expressing Mesenchymal Stem Cells Target Cancer Cells In Situ
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Reagan MR, Seib FP, McMillin D, Sage EK, Mitsiades , Janes SM, Ghobrial I, Kaplan DL
- KMID: 2286452
- J Breast Cancer.
- 2012 Sep;15(3):273-282.
- doi: 10.4048/jbc.2012.15.3.273
PURPOSE: Tumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains challenging. Herein we demonstrate the utility of a scaffold-based delivery system for sustained... -
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