Nat Prod Sci.  2019 Sep;25(3):215-221. 10.20307/nps.2019.25.3.215.

Anti-inflammatory Activity of Sambucus Plant Bioactive Compounds against TNF-α and TRAIL as Solution to Overcome Inflammation Associated Diseases: The Insight from Bioinformatics Study

Affiliations
  • 1Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Indonesia.
  • 2Department of Nutrition, Faculty of Medicine, Halu Oleo University, Indonesia.
  • 3Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Indonesia. rifa123@ub.ac.id

Abstract

Inflammation is the crucial biological process of immune system which acts as body's defense and protective response against the injuries or infection. However, the systemic inflammation devotes the adverse effects such as multiple inflammation associated diseases. One of the best ways to treat this entity is by blocking the tumor necrosis factor alpha (TNF-α) and TNF-related apoptosis-inducing ligand (TRAIL) to avoid the proinflammation cytokines production. Thus, this study aims to evaluate the potency of Sambucus bioactive compounds as anti-inflammation through in silico approach. In order to assess that, molecular docking was performed to evaluate the interaction properties between the TNF-α or TRAIL with the ligands. The 2D structure of ligands were retrieved online via PubChem and the 3D protein modeling was done by using SWISS Model. The prediction results of the study showed that caffeic acid (−6.4 kcal/mol) and homovanillic acid (−6.6 kcal/mol) have the greatest binding affinity against the TNF-α and TRAIL respectively. This evidence suggests that caffeic acid and homovanillic acid may potent as anti-inflammatory agent against the inflammation associated diseases. Finally, this study needs further examination and evaluation to validate the potency of Sambucus bioactive compounds.

Keyword

Bioinformatics study; inflammation; Sambucus; TNF-α; TRAIL

MeSH Terms

Biological Processes
Computational Biology*
Computer Simulation
Cytokines
Homovanillic Acid
Immune System
Inflammation*
Ligands
Plants*
Sambucus*
TNF-Related Apoptosis-Inducing Ligand
Tumor Necrosis Factor-alpha
Cytokines
Homovanillic Acid
Ligands
TNF-Related Apoptosis-Inducing Ligand
Tumor Necrosis Factor-alpha
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