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Streptomyces Cytochrome P450 Enzymes and Their Roles in the Biosynthesis of Macrolide Therapeutic Agents

Cho MA, Han S, Lim YR, Kim V, Kim H, Kim D

The study of the genus Streptomyces is of particular interest because it produces a wide array of clinically important bioactive molecules. The genomic sequencing of many Streptomyces species has revealed...
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In vitro antibacterial activity of WCM 302, a substance obtained from culture filtrate of streptomyces sp. 302, against staphylococcus aureus

Shin WS, Park JY, Koh CM

  • KMID: 1688020
  • J Korean Soc Microbiol.
  • 1992 Dec;27(6):493-500.
No abstract available.
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Tumor cell growth inhibitory factor in the culture filtrate of the streptomyces 1. in vitro cytotoxicity of tumor cell growth inhibitory factor

Kim SK, Shin WS, Park JY, Koh CM

  • KMID: 1687915
  • J Korean Soc Microbiol.
  • 1991 Aug;26(4):375-387.
No abstract available.
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Violapyrone J, alpha-Pyrone Derivative from a Marine-derived Actinomycetes, Streptomyces sp.

Leutou AS, Yang I, Seong CN, Ko J, Nam SJ

A new alpha-pyrone derivative, violapyrone J (1), and along with the two known violapyrones B (2) and C (3) were isolated from the fermentation broth of a marine actinomycete Streptomyces...
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Deuteromethylactin B from a Freshwater-derived Streptomyces sp.

Shaikh AF, Elfeki M, Landolfa S, Tanouye U, Green SJ, Murphy BT

Compared to their terrestrial and marine counterparts, little is known about the capacity of freshwater-derived actinomycete bacteria to produce novel secondary metabolites. In the current study, we highlight the disparities...
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Antagonistic Effect of Streptomyces sp. BS062 against Botrytis Diseases

Kim YS, Lee IK, Yun BS

The use of microorganisms and their secreted molecules to prevent plant diseases is considered an attractive alternative and way to supplement synthetic fungicides for the management of plant diseases. Strain...
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Salternamide E from a Saltern-derived Marine Actinomycete Streptomyces sp.

Kim SH, Shin Y, Lee SK, Shin J, Oh DC

Comprehensive chemical analysis of extracts and fractions of marine actinomycete strains led to the discovery of a new minor secondary metabolite, salternamide E (1), from a saltern-derived halophilic Streptomyces strain....
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Screening and Evaluation of Streptomyces Species as a Potential Biocontrol Agent against a Wood Decay Fungus, Gloeophyllum trabeum

Jung SJ, Kim NK, Lee DH, Hong SI, Lee JK

Two-hundred and fifty-five strains of actinomycetes isolated from soil samples were screened for their antagonistic activities against four well-known wood decay fungi (WDF), including a brown rot fungus, Gloeophyllum trabeum...
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Antifungal Substances from Streptomyces sp. A3265 Antagonistic to Plant Pathogenic Fungi

Van Minh N, Woo EE, Kim JY, Kim DW, Hwang BS, Lee YJ, Lee IK, Yun BS

In a previous study, we identified a Streptomyces sp., A3265, as exhibiting potent antifungal activity against various plant pathogenic fungi, including Botrytis cinerea, Colletotrichum gloeosporioides, and Rhizoctonia solani. This strain...
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Sequence Analysis and Potential Action of Eukaryotic Type Protein Kinase from Streptomyces coelicolor A3(2)

Roy DR, Chandra SB

  • KMID: 2166321
  • Genomics Inform.
  • 2008 Mar;6(1):44-49.
Protein kinase C (PKC) is a family of kinases involved in the transduction of cellular signals that promote lipid hydrolysis. PKC plays a pivotal role in mediating cellular responses to...
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Control Efficacy of Streptomyces sp. A501 against Ginseng Damping-off and Its Antifungal Substance

Van Minh N, Woo EE, Lee GS, Ki DW, Lee IK, Lee SY, Park K, Song J, Choi JE, Yun BS

Ginseng damping-off, caused by the fungal pathogens Rhizoctonia solani and Pythium sp., is a critical disease in ginseng seedling. In a continuing effort to find microorganisms with the potential of...
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Isolation, Identification and Optimal Culture Conditions of Streptomyces albidoflavus C247 Producing Antifungal Agents against Rhizoctonia solani AG2-2

Islam MR, Jeong YT, Ryu YJ, Song CH, Lee YS

  • KMID: 2408781
  • Mycobiology.
  • 2009 Jun;37(2):114-120.
Streptomyces albidoflavus C247 was isolated from the soil of the Gyeongsan golf course in Korea. Physiological, biochemical and 16S rDNA gene sequence analysis strongly suggested that the isolate belonged to...
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Screening of Low Molecular Metabolite, FS390 as an Inhibitor of Neurotransmitter Release from PC12 Cells

Chung YT, Kim HJ, Lee YS

  • KMID: 1937820
  • Korean J Anat.
  • 2006 Apr;39(2):91-102.
We established an in vitro experimental system using the following procedure. We first introduced tritium-labeled norepinephrine ([3H]-NE) into PC12 cells. The [3H]-NE incorporated-PC12 cells were stimulated by a high concentration...
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Optimal Conditions for Antimicrobial Metabolites Production from a New Streptomyces sp. RUPA-08PR Isolated from Bangladeshi Soil

Ripa FA, Nikkon F, Zaman S, Khondkar P

An actinomycete strain was isolated from northern part of Bangladesh and identified as a new Streptomyces species on the basis of its morphological, biochemical, cultural characteristics and 16S rRNA data....
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Antifungal Activities of Streptomyces blastmyceticus Strain 12-6 Against Plant Pathogenic Fungi

Kim YJ, Kim JH, Rho JY

Streptomyces blastmyceticus strain 12-6 was isolated from a forest soil sample of Cheonan area on the basis of strong antifungal activities against plant pathogenic fungi. Butanol extracts of the cultural...
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Anti-Inflammatory Effect of Violapyrones B and C from a Marine-derived Streptomyces sp.

Lee HS, An BJ, Kim HJ, Cho YH, Kim DI, Jang JY, Kwak JH, Lee HS, Lee YJ, Lee JS, Shin HJ

Recently, we reported violapyrones B, C, H and I, unusual 3, 4, 6-trisubstituted alpha-pyrone derivatives, from the culture broth of the marine Streptomyces sp. 112CH148. In previous studies, violapyrones have...
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Characterization of a Biflaviolin Synthase CYP158A3 from Streptomyces avermitilis and Its Role in the Biosynthesis of Secondary Metabolites

Lim YR, Han S, Kim JH, Park HG, Lee GY, Le TK, Yun CH, Kim D

Streptomyces avermitilis produces clinically useful drugs such as avermectins and oligomycins. Its genome contains approximately 33 cytochrome P450 genes and they seem to play important roles in the biosynthesis of...
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Antibacterial Activity of an Antibiotic (K-681) from Streptomyces sp. 681 against Staphylococcus aureus

Koh CM, Shin WS, Kim JB, Yi DH

  • KMID: 2146939
  • J Korean Soc Microbiol.
  • 1998 Feb;33(1):69-75.
The antimicrobial agents reduced infectious diseases significantly. However, antibiotic resistance has followed for almost every antimicrobial agent. Especially, Staphylococcus aureus was one of the most notorious for the multidrug resistance....
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A Study on Distribution of Fungi in the Trachea

Kim JH, Kim IS, Choi SJ, Chang MW

  • KMID: 2357870
  • Korean J Anesthesiol.
  • 1976 Dec;9(2):223-230.
One hundred and nine (109) trscheal swab specimens from patients undergoing surgical operation in Chungnam University Hospital were collected for identification of fungal flora in the trachea. The results are...
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Biological Properties of a Polyene Antifungal Substance(AF1) Produced from Streptomyces sp. WCM-9

Shin WS, Jung SH, Yi DH, Lee KH, Kim SK, Park JY, Koh CM

  • KMID: 1666806
  • Korean J Med Mycol.
  • 1996 Dec;1(1):47-54.
BACKGROUND: Pathogenic fungi infect humans, especially immunocompromised patients, with superficial or deeply invasive pattern. In the past 20 years, fungal infections have been increased dramatically resulted by increment of organ...
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