Biomol Ther.  2019 Feb;27(2):127-133. 10.4062/biomolther.2018.183.

Streptomyces Cytochrome P450 Enzymes and Their Roles in the Biosynthesis of Macrolide Therapeutic Agents

• Cho MA
• Han S
• Lim YR
• Kim V
• Kim H
• Kim D

• KMID: 2442003
• DOI: http://doi.org/10.4062/biomolther.2018.183

Abstract

The study of the genus Streptomyces is of particular interest because it produces a wide array of clinically important bioactive molecules. The genomic sequencing of many Streptomyces species has revealed unusually large numbers of cytochrome P450 genes, which are involved in the biosynthesis of secondary metabolites. Many macrolide biosynthetic pathways are catalyzed by a series of enzymes in gene clusters including polyketide and non-ribosomal peptide synthesis. In general, Streptomyces P450 enzymes accelerate the final, post-polyketide synthesis steps to enhance the structural architecture of macrolide chemistry. In this review, we discuss the major Streptomyces P450 enzymes research focused on the biosynthetic processing of macrolide therapeutic agents, with an emphasis on their biochemical mechanisms and structural insights.

Keyword

Streptomyces; P450; CYP; Biosynthesis; Macrolide; Secondary metabolite

MeSH Terms

Biosynthetic Pathways
Chemistry
Cytochrome P-450 Enzyme System*
Cytochromes*
Multigene Family
Streptomyces*
Cytochrome P-450 Enzyme System
Cytochromes