- CTCF as a multifunctional protein in genome regulation and gene expression
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Kim S, Yu NK, Kaang BK
- KMID: 2155420
- Exp Mol Med.
- 2015 Jun;47(6):e166.
- doi: 10.1038/emm.2015.33
CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator... -
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- PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity
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Lee SJ, Lee JR, Hah HS, Kim YH, Ahn JH, Bae CD, Yang JM, Hahn MJ
- KMID: 756067
- Exp Mol Med.
- 2007 Aug;39(4):450-457.
Zinc finger protein 133 (ZNF133) is composed of a Kruppel-associated box (KRAB) domain and 14 contiguous zinc finger motifs. ZNF133 is regarded as a transcriptional repressor because the KRAB domain... -
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- A Role for Timely Nuclear Translocation of Clock Repressor Proteins in Setting Circadian Clock Speed
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Lee E, Kim EY
- KMID: 2165522
- Exp Neurobiol.
- 2014 Sep;23(3):191-199.
- doi: 10.5607/en.2014.23.3.191
By means of a circadian clock system, all the living organisms on earth including human beings can anticipate the environmental rhythmic changes such as light/dark and warm/cold periods in a... -
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- Dissecting the molecular mechanism of nuclear receptor action: transcription coactivators and corepressors
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Lee JW, Cheong JH, Lee YC, Na SY, lee SK
- KMID: 1109302
- Exp Mol Med.
- 2000 Jun;32(2):53-60.
No abstract available. -
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- MAD2 Expression in Ovarian Carcinoma: Different Expression Patterns and Levels among Various Types of Ovarian Carcinoma and Its Prognostic Significance in High-Grade Serous Carcinoma
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Park PE, Jeong JY, Kim SZ, Park JY
- KMID: 2141002
- Korean J Pathol.
- 2013 Oct;47(5):418-425.
BACKGROUND: Mitotic arrest deficiency protein 2 (MAD2) is a key component of spindle assembly checkpoint function, which mediates cell apoptosis through microtubule kinetics. Aberrant expression of MAD2 is believed to... -
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- Expression of neurotensin/neuromedin N precursor in murine mast cells
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Ahn HJ, Cho JJ
- KMID: 1607138
- Korean J Physiol Pharmacol.
- 2001 Dec;5(6):495-501.
We have cloned the mouse neurotensin/neuromedin N (NT/N) gene from the murine mast cell line C1.MC/C57.1 for the first time. The murine NT/N cDNA clone consisted of 765 nucleotides and... -
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- Effects of Transplantation with Marrow-Derived Mesenchymal Stem Cells Modified with Survivin on Renal Ischemia-Reperfusion Injury in Mice
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Yuzeng Q, Weiyang H, Xin G, Qingson Z, Youlin K, Ke R
- KMID: 2130843
- Yonsei Med J.
- 2014 Jul;55(4):1130-1137.
- doi: 10.3349/ymj.2014.55.4.1130
PURPOSE: To determine whether renal injury induced by ischemia-reperfusion (I/R) could be further improved by mesenchymal stem cells (MSCs) modified with survivin. MATERIALS AND METHODS: Lentiviral vectors were used to introduce... -
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- Bone Morphogenetic Protein Signaling: Implications in Urology
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Jeong J, Kang DI, Lee GT, Kim IY
- KMID: 1997017
- Korean J Urol.
- 2010 Aug;51(8):511-517.
- doi: 10.4111/kju.2010.51.8.511
The bone morphogenetic proteins (BMPs), as members of the transforming growth factor-beta (TGF-beta) superfamily, not only control bone formation, but also regulate multiple key steps during embryonic development and differentiation.... -
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- Diagnostic Utility of Multiprobe Fluorescence in situ Hybridization Assay for Detecting Cytogenetic Aberrations in Acute Leukemia
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Kim BR, Choi JL, Kim JE, Woo KS, Kim KH, Kim JM, Kim SH, Han JY
- KMID: 1791920
- Ann Lab Med.
- 2014 May;34(3):198-202.
- doi: 10.3343/alm.2014.34.3.198
BACKGROUND: Specific cytogenetic aberrations detected by conventional karyotyping or FISH play a major role in the diagnosis, prognosis, and treatment of patients with acute leukemia. The FISH technique enhances the... -
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- Weakening of the repressive YY-1 site on the thrombospondin-1 promoter via c-Jun/YY-1 interaction
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Kang JH, Chang SY, Yeom DH, Kim SA, Um SH, Hong KJ
- KMID: 1094074
- Exp Mol Med.
- 2004 Aug;36(4):300-310.
Thrombospondin-1 (TSP-1) level is tightly regulated at the transcriptional level. To determine the detailed molecular mechanisms of TSP-1 expression, nine serial 5'-deletion constructs of the human genomic tsp-1 promoter (nucleotides... -
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- Prognostic and Clinicopathological Significance of Transducer-Like Enhancer of Split 1 Expression in Gastric Cancer
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Lee JH, Son MW, Kim KJ, Oh MH, Cho H, Lee HJ, Jang SH, Lee MS
- KMID: 2372549
- J Gastric Cancer.
- 2016 Mar;16(1):21-27.
- doi: 10.5230/jgc.2016.16.1.21
PURPOSE: Transducer-like enhancer of split 1 (TLE1) is a member of the Groucho/TLE family of transcriptional co-repressors that regulate the transcriptional activity of numerous genes. TLE1 is involved in the... -
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- Activation of NF-κB and AP-1 Mediates Hyperproliferation by Inducing β-Catenin and c-Myc in Helicobacter pylori-Infected Gastric Epithelial Cells
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Byun E, Park B, Lim JW, Kim H
- KMID: 2374084
- Yonsei Med J.
- 2016 May;57(3):647-651.
- doi: 10.3349/ymj.2016.57.3.647
PURPOSE: In the gastric mucosa of Helicobacter pylori (H. pylori)-infected patients with gastritis or adenocarcinoma, proliferation of gastric epithelial cells is increased. Hyperproliferation is related to induction of oncogenes, such... -
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- Akt is involved in the inhibition of cell proliferation by EGF
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Jeon SH, Jeong WJ, Cho JY, Lee KH, Choi KY
- KMID: 756072
- Exp Mol Med.
- 2007 Aug;39(4):491-498.
Axin is a negative regulator of the Wnt/beta-catenin pathway and is involved in the regulation of axis formation and proliferation. Involvement of Axin in the regulation of other signaling pathways... -
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- Frequency and Clinical Characteristics of Intrachromosomal Amplification of Chromosome 21 in Korean Childhood B-lineage Acute Lymphoblastic Leukemia
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Kim J, Lyu CJ, Shin S, Lee ST, Choi JR
- KMID: 2373579
- Ann Lab Med.
- 2016 Sep;36(5):475-480.
- doi: 10.3343/alm.2016.36.5.475
BACKGROUND: Intrachromosomal amplification of chromosome 21 (iAMP21) is known to be associated with poor prognosis in B-cell ALL (B-ALL). To determine the frequency and clinical characteristics of iAMP21 in Korean... -
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- A de novo Microdeletion of ANKRD11 Gene in a Korean Patient with KBG Syndrome
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Lim JH, Seo EJ, Kim YM, Cho HJ, Lee JO, Cheon CK, Yoo HW
- KMID: 1791956
- Ann Lab Med.
- 2014 Sep;34(5):390-394.
- doi: 10.3343/alm.2014.34.5.390
KBG syndrome is a very rare genetic disorder characterized by macrodontia of upper central incisors, global developmental delay, distinctive craniofacial features, short stature, and skeletal anomalies. Ankyrin repeat domain 11... -
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- Growth and Invasion of Sporadic Colorectal Adenocarcinomas in Terms of Genetic Change
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Roh SA, Choi EY, Cho DH, Jang SJ, Kim SY, Kim YS, Kim JC
- KMID: 1778028
- J Korean Med Sci.
- 2010 Mar;25(3):353-360.
- doi: 10.3346/jkms.2010.25.3.353
Integrative genetic changes were examined in relation to tumor growth and progression of sporadic colorectal cancers. Ninety-two sporadic colorectal cancer patients and 12 human colorectal cancer cell lines were evaluated.... -
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- Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled
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Jung H, Kim HJ, Lee SK, Kim R, Kopachik W, Han JK, Jho EH
- KMID: 1009391
- Exp Mol Med.
- 2009 Oct;41(10):695-706.
- doi: 10.3858/emm.2009.41.10.076
Wnt signaling is known to be important for diverse embryonic and post-natal cellular events and be regulated by the proteins Dishevelled and Axin. Although Dishevelled is activated by Wnt and... -
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- Clinicopathologic and Prognostic Significance of Transducin-Like Enhancer of Split 1 Protein Expression in Invasive Breast Cancer
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Lee JH, Bae SB, Oh MH, Cho HD, Jang SH, Hong SA, Cho J, Kim SY, Han SW, Lee JE, Kim HJ, Lee HJ
- KMID: 2379398
- J Breast Cancer.
- 2017 Mar;20(1):45-53.
- doi: 10.4048/jbc.2017.20.1.45
PURPOSE: Transducin-like enhancer of split 1 (TLE1) is a member of the TLE family of transcriptional co-repressors that control the transcription of a wide range of genes. We investigated the... -
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- Mutation analysis of p31(comet) gene, a negative regulator of Mad2, in human hepatocellular carcinoma
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Yun MY, Kim SB, Park S, Han CJ, Han YH, Yoon SH, Kim SH, Kim CM, Choi DW, Cho MH, Park GH, Lee KH
- KMID: 756074
- Exp Mol Med.
- 2007 Aug;39(4):508-513.
Failure of mitotic checkpoint machinery leads to the chromosomal missegregation and nuclear endoreduplication, thereby driving the emergence of aneuploidy and tetraploidy population. Although abnormal nuclear ploidy and the resulting impairment... -
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- Helicobacter pylori Urease Activity is Influenced by Ferric Uptake Regulator
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Lee JS, Choe YH, Lee JH, Lee HJ, Lee JH, Choi YO
- KMID: 1779604
- Yonsei Med J.
- 2010 Jan;51(1):39-44.
- doi: 10.3349/ymj.2010.51.1.39
PURPOSE: The role of the Ferric Uptake Regulator (FUR) in the acid resistance of Helicobacter pylori (H. pylori) has been thought to be independent of urease. However, we demonstrated in... -
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