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Identification and cDNA Cloning of the Leptin Receptor Long from ( OB-Rb ) from Rat Splenocytes

Park JH, Ju SK, Na SY, You KH, Kim KL

  • KMID: 1572935
  • Korean J Immunol.
  • 2000 Mar;22(1):31-38.
No abstract available.
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Leptin-signal transduction pathways and relationship with cancer development

Lee DH

  • KMID: 2244558
  • Korean J Gynecol Oncol.
  • 2007 Jun;18(2):67-92.
Leptin is a versatile 16 kDa peptide hormone, with tertiary structure resembling that of members of the long-chain helical cytokine family. It is mainly produced by adipocytes in proportion to...
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Expression of leptin receptors and the antiapoptotic effect of leptin on epithelial ovarian cancer cell lines

Kwon HM, Lee JY, Ahn TG, Lee HA, Hwang JY, Cho JS, Lee DH

  • KMID: 2273350
  • Korean J Obstet Gynecol.
  • 2008 May;51(5):534-543.
OBJECTIVE: The potential role of leptin as an endocrine regulator is unknown in ovarian cancer. In the present study, we investigated the expression of letpin receptors in IOSE (Immortalized ovarian...
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Effect of Leptin on the Steroidogenesis of Cultured Human Granulosa Cells

Kim SK, Cho DJ, Kim MS, Hwang KJ, Kwon HC

  • KMID: 2235709
  • Korean J Fertil Steril.
  • 2000 Mar;27(1):15-22.
OBJECTIVE: To elucidate the location of leptin and receptors of ovary specimens obtained from patients undergoing hysterectomy by immunohistochemical staining and to determine the effect of leptin on the steroidogenesis...
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Role of the Cytokine-like Hormone Leptin in Muscle-bone Crosstalk with Aging

Hamrick MW

The cytokine-like hormone leptin is a classic adipokine that is secreted by adipocytes, increases with weight gain, and decreases with weight loss. Additional studies have, however, shown that leptin is...
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Leptin and Leptin Receptor Expression in Breast Cancer

Kim HS

  • KMID: 2128577
  • Cancer Res Treat.
  • 2009 Sep;41(3):155-163.
PURPOSE: Leptin is a multifunctional hormone that's produced by adipose tissue and leptin is involved in the regulation of food intake and energy balance. The aims of this study were...
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The Effect of Leptin Level Fluctuations by a Repeated Fasting/Refeeding on the Leptin Sensitivity in OLETF Rats

Park SC, Park YH, Park SY, Kim JY, Park YK, Lee TH, Won KC, Kim YW

BACKGROUND: Leptin resistance is a common feature in obese subjects and animals, and this is commonly accompanied with hyperleptinemia. We speculated that one of the causes of leptin resistance is...
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Improvement of Leptin Resistance

Kim YW

  • KMID: 2320037
  • Yeungnam Univ J Med.
  • 2013 Jun;30(1):4-9.
Leptin, a 16-kDa cytokine, is secreted by adipose tissue in response to the surplus of fat store. Thereby, the brain is informed about the body's energy status. In the hypothalamus,...
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A Study on Serum Leptin Values by Elisa Method in Children

Song SH, Chung YH

PURPOSE: Leptin is an adipocyte-derived blood-borne satiety factor that acts on its cognate leptin receptor in the hypothalamus, thereby regulating food intake and energy expenditure. We measured the leptin concentrations...
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Induction of IL-6 and IL-8 Expression by Leptin Treatment in Periodontal Ligament Cells and Gingival Fibroblasts

Park HG, Kim JH, Cha JH, Bak EJ, Yoo YJ

  • KMID: 1431098
  • Int J Oral Biol.
  • 2013 Jun;38(2):73-80.
Leptin is one of the adipocytokines produced from adipose tissue but its functions in periodontal tissue have not previously been investigated. In our current study, we examined the effects of...
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Expression of Leptin, Leptin Receptor, Adiponectin, and Adiponectin Receptor in Ductal Carcinoma In Situ and Invasive Breast Cancer

Jeong YJ, Bong JG, Park SH, Choi JH, Oh HK

PURPOSE: Adipocytokines, such as leptin, resistin, and adiponectin, are associated with obesity and breast cancer. Several studies have indicated that adipocytokines may influence tumor growth or differentiation. The aims of...
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Susceptibility of gastric cancer according to leptin and leptin receptor gene polymorphisms in Korea

Kim EY, Chin HM, Park SM, Jeon HM, Chung WC, Paik CN, Jun KH

PURPOSE: Leptin plays an important role in the control of body weight and also has a growth-factor-like function in epithelial cells. Abnormal expression of leptin and leptin receptor may be...
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Vagal Control of Satiety and Hormonal Regulation of Appetite

Owyang C, Heldsinger A

  • KMID: 2325834
  • J Neurogastroenterol Motil.
  • 2011 Oct;17(4):338-348.
The paradigm for the control of feeding behavior has changed significantly. In this review, we present evidence that the separation of function in which cholecystokinin (CCK) controls short-term food intake...
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Expression of OB-R, Regulation of Mitogen Activated Protein Kinase Activity and Maturation by Leptin in Mouse Oocytes

Kang BM, Han HJ, Seo HY, Hong SH, Gye MC

  • KMID: 1891260
  • Korean J Fertil Steril.
  • 2001 Jun;28(2):111-120.
OBJECTIVE: To verify the expression of leptin receptor (OB-R) in oocytes and preimplantation embryos, the involvement of mitogen activated protein kinase (MAPK or Erk1/2) in the leptin signaling, and effect...
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A review on gastric leptin: the exocrine secretion of a gastric hormone

Cammisotto P, Bendayan M

A major advance in the understanding of the regulation of food intake has been the discovery of the adipokine leptin a hormone secreted by the adipose tissue. After crossing the...
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Leptin: A Multifunctional Role as an Immunomodulator in Mycobacterial Lung Disease

Song J, Shin SJ, Kim JS

Leptin is a 16 kDa protein which consists of 167 amino acids. Leptin is considered as one of the adipokines, secreted by white adipocytes, and is the product of the...
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Correlation between the Serum Leptin Level and the Expression of Leptin in Stomach Cancer Patients

Kim JH, Jung H, Jun KH, Kim SK, Chin HM, Jung JH, Kim W, Jeon HM, Park CH, Park SM, Park WB, Lim KW, Kim SN

  • KMID: 2372915
  • J Korean Gastric Cancer Assoc.
  • 2008 Dec;8(4):176-181.
PURPOSE: The adipocyte-derived cytokine leptin plays a major role in the control of stable body weight by suppressing food intake and increasing energy metabolism. Leptin regulates the cell proliferation of...
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Expression of immunoreactive leptin and its receptor in epithelial ovarian cancer

Kim YJ, Cho BS, Cho SH, Kim KT, Park MI

  • KMID: 2273498
  • Korean J Obstet Gynecol.
  • 2008 Oct;51(10):1094-1102.
OBJECTIVE: Leptin, a secreted protein of the Ob gene by white adipose tissue, plays an important role in the regulation of food intake and energy consumption in the brain and...
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Mechanism of Leptin-Induced Potentiation of Catecholamine Secretion Evoked by Cholinergic Stimulation in the Rat Adrenal Medulla

Lim DY, Choi DH, Kang MJ

  • KMID: 1611351
  • Korean J Physiol Pharmacol.
  • 2004 Aug;8(4):227-235.
The aim of the present study was to examine the effect of leptin on CA release from the isolated perfused model of the rat adrenal gland, and to establish its...
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Leptin potentiates Prevotella intermedia lipopolysaccharide-induced production of TNF-alpha in monocyte-derived macrophages

Kim SJ

PURPOSE: In addition to regulating body weight, leptin is also recognized for its role in the regulation of immune function and inflammation. The purpose of this study was to investigate...
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