- Molecular Basis of Drug Resistance: Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Anaplastic Lymphoma Kinase Inhibitors
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Yang SH
- KMID: 2320467
- Tuberc Respir Dis.
- 2013 Nov;75(5):188-198.
Over the past decade, several kinase inhibitors have been approved based on their clinical benefit in cancer patients. Unfortunately, in many cases, patients develop resistance to these agents via secondary... -
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- Biopsy and Mutation Detection Strategies in Non-Small Cell Lung Cancer
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Jung CY
- KMID: 2320466
- Tuberc Respir Dis.
- 2013 Nov;75(5):181-187.
The emergence of new therapeutic agents for non-small cell lung cancer (NSCLC) implies that histologic subtyping and molecular predictive testing are now essential for therapeutic decisions. Histologic subtype predicts the... -
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- The Expressions of Tyrosine Kinase Receptors, EphA2, c-met and c-erbB-2 in the Human Breast
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Min SK, Cho HD, Cho SJ, Park HR, Shin HS, Park YE, Yeom BW
- KMID: 2275437
- Korean J Pathol.
- 2005 Feb;39(1):15-22.
BACKGROUND: Tyrosine kinase receptor (TKR) is an important protein for normal-development, growth and tumorigenesis in human tissues. The purpose of this study was to evaluate the effect of TKR in... -
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- Role of Shc and phosphoinositide 3-kinase in heregulin-induced mitogenic signaling via ErbB3
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Kim MS, Koland JG
- KMID: 1581029
- Korean J Physiol Pharmacol.
- 2000 Dec;4(6):507-513.
ErbB3/HER3 is a cell surface receptor which belongs to the ErbB/HER subfamily of receptor protein tyrosine kinases. When expressed in NIH/3T3 cells, ErbB3 can form heterodimeric coreceptor with endogenous ErbB2. Among known intracellular... -
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- LRIG1 Enhances Chemosensitivity by Modulating BCL-2 Expression and Receptor Tyrosine Kinase Signaling in Glioma Cells
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Guo Z, Chen Q, Liu B, Tian D, Zhang S, Li M
- KMID: 1799481
- Yonsei Med J.
- 2014 Sep;55(5):1196-1205.
- doi: 10.3349/ymj.2014.55.5.1196
PURPOSE: Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) are an inhibitor of receptor tyrosine kinases (RTKs) that was discovered in recent years, and many studies showed that LRIG1 is a... -
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- A Case of CD30 (+)/ALK (-) Systemic Anaplastic Large Cell Lymphoma
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Park YD, Chung SL, Lee KS
- KMID: 2302095
- Korean J Dermatol.
- 2008 Mar;46(3):414-417.
Systemic CD30 positive anaplastic large cell lymphoma (ALCL), a subtype of non-Hodgkin lymphoma (NHL), developes in the internal organs and invades the skin. There have been many cases of primary... -
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- Evolving Cancer Classification in the Era of Personalized Medicine: A Primer for Radiologists
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O'Neill AC, Jagannathan JP, Ramaiya NH
- KMID: 2468118
- Korean J Radiol.
- 2017 Feb;18(1):6-17.
- doi: 10.3348/kjr.2017.18.1.6
Traditionally tumors were classified based on anatomic location but now specific genetic mutations in cancers are leading to treatment of tumors with molecular targeted therapies. This has led to a... -
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- The biologic role of ganglioside in neuronal differentiation: effects of GM1 ganglioside on human neuroblastoma SH-SY5Y cells
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Lee MC, Lee WS, Park CS, Juhng SW
- KMID: 1422174
- J Korean Med Sci.
- 1994 Apr;9(2):179-187.
- doi: 10.3346/jkms.1994.9.2.179
Human neuroblastoma SH-SY5Y cell is a cloned cell line which has many attractive features for the study of neuronal proliferation and neurite outgrowth, because it has receptors for insulin, IGF-I... -
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- A Case of CD30 (+)/ALK (-) Primary Systemic AnaplasticLarge Cell Lymphoma with Atypical Clinical Features
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Yang YS, Jeong KH, Cho HR, Haw CR, Kim NI
- KMID: 2248083
- Korean J Dermatol.
- 2008 Oct;46(10):1419-1423.
Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin's lymphoma, and this tumor is predominantly composed of large lymphoid cells that have a strong expression of CD30. Two major... -
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- Genopathogenesis of Colorectal Cancer
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Kim JC
- KMID: 1940530
- J Korean Surg Soc.
- 2005 Sep;69(3):189-198.
Cancer occurs from the functional derangements of complex genomic structure. Colorectal carcinogenesis, from hereditary colorectal cancers, has been widely investigated by excavating their related genes. Colorectal carcinogenesis is significantly implicated... -
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- Expression of Platelet Derived Growth Factor-A, C and Platelet Derived Growth Factor Receptor-alpha in the Ischemia Reperfusion Renal Failure Model
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Kang KP, Kim W, Moon CY, Jang YB, Lee S, Moon SO, Sung MJ, kIm DH, Kang SK, Park SK
- KMID: 2079574
- Korean J Nephrol.
- 2006 Jan;25(1):13-22.
BACKGOUND: Platelet-derived growth factor (PDGF) is a widely expressed growth factor with both mitogenic and chemotactic activities in many connective tissue cell types. There are four members of PDGF family;... -
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- KIT/PDGFRA Expression and Mutation in Testicular Seminoma and Ovarian Dysgerminoma
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Choi SY, Suh KS, Kim YB, Lee HJ, Kim ES, Park MJ
- KMID: 1472638
- Korean J Pathol.
- 2009 Dec;43(6):528-534.
- doi: 10.4132/KoreanJPathol.2009.43.6.528
BACKGROUND: KIT and PDGFRA are tyrosine kinase receptors. Stem cell factor/KIT-mediated signaling plays a role in normal spermatogenesis, and the alteration of KIT is important in the pathogenesis of seminomas/dysgerminomas... -
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- A Case of Anaplastic Lymphoma Kinase-Negative Primary Gastric Anaplastic Large Cell Lymphoma
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Kim HS, Park KW, Lee JL, Bae SH, Do WS, Kim MY, Lee SA
- KMID: 2263420
- Korean J Med.
- 2012 Nov;83(5):674-678.
Primary malignant lymphoma of the stomach comprises 1 to 7% of all gastric malignancies and is mostly B-cell type. Anaplastic large cell lymphoma (ALCL) of the stomach is very rare... -
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- A Case of Primary Cutaneous Anaplastic Large Cell Lymphoma Mimmicking Keratoacanthoma
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Kim ST, Baek JW, Kim TK, Lee JW, Roh HJ, Jeon YS, Suh KS
- KMID: 1472462
- Korean J Dermatol.
- 2009 Jan;47(1):84-88.
Pseudoepitheliomatous hyperplasia with a massive neutrophil infiltrate associated with primary cutaneous anaplastic large cell lymphoma has been rarely reported. Herein we report on a 33-year-old man who presented with multiple... -
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- Histologic Features of ALK-Expressing Adenocarciomas of the Lung
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Song HJ, Jeong JY, Choi Y, Han J
- KMID: 2199892
- J Lung Cancer.
- 2011 Jun;10(1):32-36.
- doi: 10.6058/jlc.2011.10.1.32
PURPOSE: This study was designed to define the specific histologic features of anaplastic lymphoma kinase (ALK)-expressing pulmonary adenocarcinoma. MATERIALS AND METHODS: Of the 580 pulmonary adenocarcinomas diagnosed between March 2010 and... -
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- Sclerosing Angiomatoid Nodular Transformation (SANT) in Spleen: A Case Report
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Lee HJ, Choi SY, Huang SM, Sul JY, Kim JM
- KMID: 2277529
- Korean J Pathol.
- 2011 Feb;45(1):111-114.
Sclerosing angiomatoid nodular transformation (SANT) of spleen is a rare inflammatory tumor-like vascular lesion composed of angiomatoid nodules in a fibrosclerotic background. We report herein on a case of SANT... -
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- Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
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Ha SY, Ahn J, Roh MS, Han J, Lee JJ, Lee B, Yim J
- KMID: 2277442
- Korean J Pathol.
- 2013 Jun;47(3):252-257.
BACKGROUND: The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma. METHODS: We analyzed the cytopathological findings of 15 cases of endobronchial... -
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- Expression of Ca2+ -activated K+ Channels and Their Role in Proliferation of Rat Cardiac Fibroblasts
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Choi S, Lee W, Yun J, Seo J, Lim I
- KMID: 1486143
- Korean J Physiol Pharmacol.
- 2008 Apr;12(2):51-58.
- doi: 10.4196/kjpp.2008.12.2.51
Cardiac fibroblasts constitute one of the largest cell populations in the heart, and contribute to structural, biochemical, mechanical and electrical properties of the myocardium. Nonetheless, their cardiac functions, especially electrophysiological... -
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- Peptide Nucleic Acid Clamping and Direct Sequencing in the Detection of Oncogenic Alterations in Lung Cancer: Systematic Review and Meta-Analysis
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Song JU, Lee J
- KMID: 2418783
- Yonsei Med J.
- 2018 Mar;59(2):211-218.
- doi: 10.3349/ymj.2018.59.2.211
PURPOSE: Molecular testing in non-small cell lung cancer (NSCLC) aids in identifying oncogenic alterations. The aim of this study was to compare the rates of detection of oncogenic alterations and... -
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- A Case of Primary Gastric ALK-Positive Anaplastic Large-Cell Lymphoma
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Chang WS, Jeong WJ, Kang KH, Kwon JH, Hong JS, Eom DW, Cheon GJ
- KMID: 2264784
- Korean J Med.
- 2012 Dec;83(6):752-756.
Anaplastic large-cell lymphoma (ALCL) is a rare subgroup of non-Hodgkin's lymphoma. Primary gastric ALCL is extremely rare. Patients with anaplastic lymphoma kinase (ALK)-positive primary systemic ALCL are known to have... -
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