Korean J Pathol.
2013 Jun;47(3):252-257.
Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
- Affiliations
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- 1Department of Pathology, Gachon University Gil Medical Center, Incheon, Korea.
- 2Department of Pathology, Dong-A University College of Medicine, Busan, Korea.
- 3Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. hanjho@skku.edu
- 4Department of Preventive Medicine, Graduate School of Medicine, Gachon University, Incheon, Korea.
Abstract
- BACKGROUND
The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma.
METHODS
We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases were selected based on the histomorphology of ALK-rearranged lung adenocarcinoma.
RESULTS
Cytology showed mucinous (81.3%) and hemorrhagic (50%) backgrounds. The cells were arranged in tubulopapillary or tubulocribriform patterns (93.8%), and clusters (56.3%) admixed with signet ring cell features (87.5%). The tumor cells were monotonous and uniform with vesicular nuclei and a small nucleolus.
CONCLUSIONS
The characteristic findings were sheets showing a tubulopapillary or tubulocribriform appearance, with vesicular nuclei and a bland chromatin pattern (p<0.001). Scattered signet ring cells were helpful in suggesting ALK-positive adenocarcinoma (p<0.001).
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