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Heart Transplantation in a Patient with Complex Congenital Heart Disease, Physiologic Single Lung, and Severe Pulmonary Hypertension

Lee HW, Jung JW, Kim AY, Park HK

Here we report a case of successful heart transplantation (HT) in a patient with high risk on HT due to her complex congenital heart disease and its consequent complications; physiologic...
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An Unusual Case of Basal Cell Carcinoma with Lung and Endobronchial Metastasis

Kim T, Kim DH, Lee SE, Yang MY, Kim YS

Recently, some cases of basal cell carcinoma (BCC) with lung metastasis have been reported, but those involving simultaneous tracheal, bronchial, and lung metastases have been rarely reported. Here, we have...
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Dexmedetomidine attenuates subarachnoid hemorrhage-induced acute lung injury through regulating autophagy and TLR/NFκB signaling pathway

Han DW, Oh JE, Lim BJ, Han Y, Song Y

Background: Acute lung injury (ALI) is the most serious complication of subarachnoid hemorrhage (SAH). We investigated role of autophagy and inflammatory signaling pathways in lung damage and therapeutic effects of...
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Biomarker testing of cytology specimens in personalized medicine for lung cancer patients

Kim H, Chung JH

Every patient with advanced non–small cell lung cancer (NSCLC) should be tested for targetable driver mutations and gene arrangements that may open avenues for targeted therapy. As most patients with...
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Reduced Diffusing Capacity in Humidifier Disinfectant-Associated Asthma Versus Typical Asthma: A Retrospective Case Control Study

Pak C, Cowl CT, Kim JH, Kang BJ, Lee T, Jegal Y, Ra SW, Kim Y

Background: Humidifier disinfectant-related lung injury (HDLI) is a severe form of toxic inhalational pulmonary parenchymal damage found in residents of South Korea previously exposed to specific guanidine-based compounds present in...
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Usefulness of BRAF VE1 immunohistochemistry in non–small cell lung cancers: a multi-institutional study by 15 pathologists in Korea

Chang S, Choi YL, Shim HS, Lee GK, Ha SY, Korean Cardiopulmonary Pathology Study Group

Background: Next-generation sequencing (NGS) is an approved test to select patients for BRAF V600E targeted therapy in Korea. However, the high cost, long turnaround times, and the need for sophisticated...
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Scalp metastasis from an adenocarcinoma of the lung mimicking a cystic mass: case report and literature review

Kim HK, Kang SH, Kim WS, Kang SH, Kim WJ, Kim HS, Bae TH

A 67-year-old man visited our plastic surgery clinic complaining of a palpable protruding mass (2.0 × 2.5 cm) in the right occipital region. To establish an appropriate treatment plan for...
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New Atrial Anastomosis Technique for an Inadequate Left Atrial Cuff in Lung Transplantation

In lung transplantation surgery, the pulmonary veins are anastomosed by connecting each atrium of the donor and recipient. However, occasionally the recipient’s left atrium is not suitable for anastomosis for...
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Pulmonary Malakoplakia Associated with Peripheral Cysts in an Immunocompetent Patient: A Case Report

Corrêa LF, Bento da Silva TK, Camargo SM, Furian BC

Pulmonary malakoplakia is a rare lung lesion more frequently found in immunocompromised patients than in immunocompetent individuals. In this study, we report the challenging case of a young immunocompetent patient...
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Outcomes of Patients on the Lung Transplantation Waitlist in Korea: A Korean Network for Organ Sharing Data Analysis

Yeo HJ, Oh DK, Yu WS, Choi SM, Jeon K, Ha M, Lee JG, Cho WH, Kim YT

Background: The demand for lung transplants continues to increase in Korea, and donor shortages and waitlist mortality are critical issues. This study aimed to evaluate the factors that affect waitlist...
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Adverse Effects of Air Pollution on Pulmonary Diseases

Ko UW, Kyung SY

Environmental exposure to air pollution is known to have adverse effects on various organs. Air pollution has greater effects on the pulmonary system as the lungs are directly exposed to...
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Artificial Intelligence-Based Identification of Normal Chest Radiographs: A Simulation Study in a Multicenter Health Screening Cohort

Yoo H, Kim EY, Kim H, Choi YR, Kim MY, Hwang SH, Kim YJ, Cho YJ, Jin KN

Objective: This study aimed to investigate the feasibility of using artificial intelligence (AI) to identify normal chest radiography (CXR) from the worklist of radiologists in a health-screening environment. Materials and Methods:...
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Relationship between Incidental Abnormalities on Screening Thoracic Computed Tomography and Mortality: A Long-Term Follow-Up Analysis

Lee JE, Jeong WG, Lee HJ, Kim YH, Chae KJ, Jeong YJ

Objective: The present study aimed to assess the relationship between incidental abnormalities on thoracic computed tomography (CT) and mortality in a general screening population using a long-term follow-up analysis. Materials and...
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Transbronchial Lung Cryobiopsy for Diagnosing Interstitial Lung Disease: A Retrospective Single-Center Experience

Park JH, Jang JH, Kim HK, Jang HJ, Lee S, Kim SH, Kim JY, Choi HE, Han Jy, Kim DS, Kang MK, Kang E, Kim IH, Lee JH

Background: An accurate diagnosis in patients with interstitial lung diseases (ILDs) by multidisciplinary discussion (MDD) based on histopathologic information is essential for optimal treatment. Transbronchial lung cryobiopsy (TBLC) has increasingly...
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Epidemiologic study of epidural analgesia for lung cancer surgery from 2011 to 2018 in South Korea: a National Health Insurance Database cohort study

Oh TK, Song IA

Background: Epidural analgesia is commonly used for pain control during lung cancer surgery. However, the clinical trends in epidural analgesia, associated factors, and their association with clinical outcomes remain controversial....
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Long-Term Outcome of Chronic Obstructive Pulmonary Disease: A Review

Jo YS

Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammation characterized by fixed airflow limitation and chronic respiratory symptoms, such as cough, sputum, and dyspnea. COPD is a progressive disease...
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Expandable Lung Epithelium Differentiated from Human Embryonic Stem Cells

Kotasová H, apandová M, Pelková V, Dumková J, Koledová Z, Remsˇı ´k J, Soucˇek K, Garlı´ková Z, Sedláková V, Rabata A, Vanˇhara P, Morán L, Pecˇinka L, Porokh V, Kucˇı´rek M, Streit L, Havel J, Hampl A

BACKGROUND The progenitors to lung airway epithelium that are capable of long-term propagation may represent an attractive source of cells for cell-based therapies, disease modeling, toxicity testing, and others. Principally,...
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Long-term Exposure to PM10 Increases Lung Cancer Risks: A Cohort Analysis

Lee HW, Kang SC, Kim SY, Cho YJ, Hwang S

Purpose Although lung cancer incidences in female never-smokers have increased, few studies focus on explicit investigation. We aimed to investigate the relationship between long-term exposure to ambient particulate matter sized 10...
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Assessment of Anti-tumor Efficacy of Osimertinib in Non-Small Cell Lung Cancer Patients by Liquid Biopsy Using Bronchoalveolar Lavage Fluid, Plasma, or Pleural Effusion

Kim YJ, Ji WJ, Lee JC, Chun SM, Choi CM

Purpose This study was to evaluate anti-tumor efficacy of osimertinib in patients positive for acquired epidermal growth factor receptor (EGFR) T790M mutation in liquid biopsy using plasma, bronchoalveolar lavage fluid (BALF)...
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A Phase I/IIa Randomized Trial Evaluating the Safety and Efficacy of SNK01 Plus Pembrolizumab in Patients with Stage IV Non-Small Cell Lung Cancer

Kim EJ, Cho YH, Kim DH, Ko DH, Do EJ, Kim SY, Kim YM, Jung JS, Kang Y, Ji W, Choi MG, Lee JC, Rho JK, Choi CM

Purpose The aim of this study is to evaluate the safety and efficacy of ex vivo activated and expanded natural killer (NK) cell therapy (SNK01) plus pembrolizumab in a randomized...
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