- Fluoxetine Induces Apoptotic and Oxidative Neuronal Death Associated with The Influx of Copper Ions in Cultured Neuronal Cells
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Hwang S, Kim JK
- KMID: 2468142
- Chonnam Med J.
- 2020 Jan;56(1):20-26.
- doi: 10.4068/cmj.2020.56.1.20
We examined the effect of fluoxetine, a selective serotonin reuptake inhibitor antidepressant, on neuronal viability in mouse cortical near-pure neuronal cultures. Addition of fluoxetine to the media for 24 hours... -
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- Proteomic Signatures in Spermatozoa Reveal the Role of Paternal Factors in Recurrent Pregnancy Loss
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Mohanty G, Jena SR, Nayak J, Kar S, Samanta L
- KMID: 2465415
- World J Mens Health.
- 2020 Jan;38(1):103-114.
- doi: 10.5534/wjmh.190034
PURPOSE: To identify the paternal factors responsible for aberrant embryo development leading to loss of foetus in recurrent pregnancy loss (RPL) through proteomic analysis of ejaculated spermatozoa. MATERIALS AND METHODS: This... -
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- Specific tail swelling pattern in hypo-osmotic solution as a predictor of DNA fragmentation status in human spermatozoa
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Kim SW, Nho EJ, Lee JY, Jee BC
- KMID: 2469590
- Clin Exp Reprod Med.
- 2019 Dec;46(4):147-151.
- doi: 10.5653/cerm.2019.00458
OBJECTIVE: The aim of this study was to investigate DNA fragmentation status in human spermatozoa according to specific tail swelling patterns determined via hypo-osmotic swelling test (HOST). METHODS: Frozen semen samples... -
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- ICSI using fresh and frozen PESA-TESA spermatozoa to examine assisted reproductive outcome retrospectively
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Javed A, Ramaiah MK, Talkad MS
- KMID: 2462121
- Obstet Gynecol Sci.
- 2019 Nov;62(6):429-437.
- doi: 10.5468/ogs.2019.62.6.429
OBJECTIVE: The male reproductive system generates, accumulates, and transports the sperm. In this study, 2 methods of surgically retrieving sperm, namely, testicular sperm aspiration (TESA) and percutaneous epididymal sperm aspiration... -
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- Syringocystadenocarcinoma Papilliferum: A Case Report and Review of the Literature
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Lee KG, Choi W, Lim JS, Hahn HJ, Myung KB, Cheong SH
- KMID: 2456234
- Ann Dermatol.
- 2019 Oct;31(5):559-562.
- doi: 10.5021/ad.2019.31.5.559
Syringocystadenocarcinoma papilliferum (SCACP) is a rare malignant adnexal neoplasm, which is considered as a malignant counterpart of syringocystadenoma papilliferum (SCAP). Clinically, SCACP appears as a nodule, inflammatory plaque, or tumor.... -
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- Pseudolaric acid B inhibits PAX2 expression through Wnt signaling and induces BAX expression, therefore promoting apoptosis in HeLa cervical cancer cells
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Guan D, Li C, Lv X, Yang Y
- KMID: 2457155
- J Gynecol Oncol.
- 2019 Sep;30(5):e77.
- doi: 10.3802/jgo.2019.30.e77
OBJECTIVES: Pseudolaric acid B (PAB) has been shown to inhibit the growth of various tumor cells, but the molecular details of its function are still unknown. This study investigated the... -
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- Angiotensin II and TGF-β1 Induce Alterations in Human Amniotic Fluid-Derived Mesenchymal Stem Cells Leading to Cardiomyogenic Differentiation Initiation
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GasiÅ«nienÄ— M, Petkus G, MatuzeviÄius D, Navakauskas D, NavakauskienÄ— R
- KMID: 2465896
- Int J Stem Cells.
- 2019 Jul;12(2):251-264.
- doi: 10.15283/ijsc18126
BACKGROUND AND OBJECTIVES: Human amniotic fluid-derived mesenchymal stem cells (AF-MSCs) may be a valuable source for cardiovascular tissue engineering and cell therapy. The aim of this study is to verify... -
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- Does conventional freezing affect sperm DNA fragmentation?
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Le MT, Nguyen TT, Nguyen TT, Nguyen TV, Nguyen TA, Nguyen QH, Cao TN
- KMID: 2452645
- Clin Exp Reprod Med.
- 2019 Jun;46(2):67-75.
- doi: 10.5653/cerm.2019.46.2.67
OBJECTIVE: Sperm cryopreservation has been widely used in assisted reproductive technology, as it offers great potential for the treatment of some types of male infertility. However, cryopreservation may result in... -
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- Effect of Sperm DNA Fragmentation on Embryo Quality in Normal Responder Women in In Vitro Fertilization and Intracytoplasmic Sperm Injection
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Kim SM, Kim SK, Jee BC, Kim SH
- KMID: 2443250
- Yonsei Med J.
- 2019 May;60(5):461-466.
- doi: 10.3349/ymj.2019.60.5.461
PURPOSE: To investigate the associations between sperm DNA fragmentation (SDF) and embryo formation rate in normal responder women to in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). MATERIALS AND METHODS: Fifty-three consecutive, fresh... -
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- Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques
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Giacone F, Cannarella R, Mongioì L, Alamo A, Condorelli RA, Calogero A, La Vignera S
- KMID: 2443230
- World J Mens Health.
- 2019 May;37(2):148-156.
- doi: 10.5534/wjmh.180071
During the last decades the study of male infertility and the introduction of the assisted reproductive techniques (ARTs) has allowed to understand that normal sperm parameters do not always predict... -
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- Nkx-2.5 Regulates MDR1 Expression via Its Upstream Promoter in Breast Cancer Cells
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Lim JS, Jung GY, Park SY
- KMID: 2442099
- J Korean Med Sci.
- 2019 Apr;34(12):e100.
- doi: 10.3346/jkms.2019.34.e100
BACKGROUND: Increased expression of MDR1 gene is one of the major mechanisms responsible for multidrug resistance in cancer cells. Two alternative promoters, upstream and downstream, are responsible for transcription of... -
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- Evaluation of sperm DNA fragmentation using multiple methods: a comparison of their predictive power for male infertility
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Javed A, Talkad MS, Ramaiah MK
- KMID: 2469602
- Clin Exp Reprod Med.
- 2019 Mar;46(1):14-21.
- doi: 10.5653/cerm.2019.46.1.14
OBJECTIVE: The usual seminal profile has been customarily used for diagnosing male infertility based on an examination of semen samples. However, sperm DNA fragmentation has also been causally linked to... -
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- Enrichment of rare alleles within epigenetic chromatin marks in the first intron
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Jo SS, Choi SS
- KMID: 2447799
- Genomics Inform.
- 2019 Mar;17(1):e9.
- doi: 10.5808/GI.2019.17.1.e9
In previous studies, we demonstrated that some sites in the first intron likely regulate gene expression. In the present work, we sought to further confirm the functional relevance of first... -
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- Splitomicin, a SIRT1 Inhibitor, Enhances Hematopoietic Differentiation of Mouse Embryonic Stem Cells
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Park JA, Park S, Park WY, Han MK, Lee Y
- KMID: 2447221
- Int J Stem Cells.
- 2019 Mar;12(1):21-30.
- doi: 10.15283/ijsc18040
BACKGROUND AND OBJECTIVES: Embryonic stem (ES) cells have pluripotent ability to differentiate into multiple tissue lineages. SIRT1 is a class III histone deacetylase which modulates chromatin remodeling, gene silencing, cell... -
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- The Function of the Vitamin D Receptor and a Possible Role of Enhancer RNA in Epigenomic Regulation of Target Genes: Implications for Bone Metabolism
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Sawatsubashi S, Nishimura , Mori J, Kouzmenko , Kato S
- KMID: 2440639
- J Bone Metab.
- 2019 Feb;26(1):3-12.
- doi: 10.11005/jbm.2019.26.1.3
Vitamin D (VD) is essential for bone health, and VD or its analogues are widely used in clinics to ameliorate bone loss. The targets and mode of VD anti-osteoporotic actions... -
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- A Short Report on the Markov Property of DNA Sequences on 200-bp Genomic Units of Roadmap Genomics ChromHMM Annotations: A Computational Perspective
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Park HS
- KMID: 2439217
- Genomics Inform.
- 2018 Dec;16(4):e27.
- doi: 10.5808/GI.2018.16.4.e27
The non-coding DNA in eukaryotic genomes encodes a language that programs chromatin accessibility, transcription factor binding, and various other activities. The objective of this study was to determine the effect... -
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- Noncoding RNAs as therapeutic targets in early stage diabetic kidney disease
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Kato M
- KMID: 2447159
- Kidney Res Clin Pract.
- 2018 Sep;37(3):197-209.
- doi: 10.23876/j.krcp.2018.37.3.197
Diabetic kidney disease (DKD) is a major renal complication of diabetes that leads to renal dysfunction and end-stage renal disease (ESRD). Major features of DKD include accumulation of extracellular matrix... -
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- A Short Report on the Markov Property of DNA Sequences on 200-bp Genomic Units of ENCODE/Broad ChromHMM Annotations: A Computational Perspective
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Park HS
- KMID: 2422814
- Genomics Inform.
- 2018 Sep;16(3):65-70.
- doi: 10.5808/GI.2018.16.3.65
The non-coding DNA in eukaryotic genomes encodes a language which programs chromatin accessibility, transcription factor binding, and various other activities. The objective of this short report was to determine the... -
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- Abrupt Dyskeratotic and Squamoid Cells in Poorly Differentiated Carcinoma: Case Study of Two Thoracic NUT Midline Carcinomas with Cytohistologic Correlation
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Lee T, Choi S, Han J, Choi YL, Lee K
- KMID: 2422103
- J Pathol Transl Med.
- 2018 Sep;52(5):349-353.
- doi: 10.4132/jptm.2018.07.16
Cytologic diagnosis of nuclear protein in testis (NUT) midline carcinoma (NMC) is important due to its aggressive behavior and miserable prognosis. Early diagnosis of NMC can facilitate proper management, and... -
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- What should be done for men with sperm DNA fragmentation?
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Kim GY
- KMID: 2419525
- Clin Exp Reprod Med.
- 2018 Sep;45(3):101-109.
- doi: 10.5653/cerm.2018.45.3.101
In an age when a small quantity of sperm can lead to pregnancy through in vitro fertilization or intracytoplasmic sperm injection, selecting healthy sperm is important. Sperm DNA fragmentation (SDF)... -
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