Genomics Inform.
2017 Dec;15(4):114-122. 10.5808/GI.2017.15.4.114.
CTCF, Cohesin, and Chromatin in Human Cancer
- Affiliations
-
- 1Cancer Genomics Research Laboratory, Cancer Research Institute, Seoul National University, Seoul 03080, Korea. kimty@snu.ac.kr
- 2Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Korea.
- 3Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea.
- KMID: 2404047
- DOI: http://doi.org/10.5808/GI.2017.15.4.114
Abstract
- It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. Their dynamic interactions in three dimensions within the nucleus regulate gene transcription by changing the chromatin architecture. Such spatial genomic organization is functionally important for the spatial disposition of chromosomes to control cell fate during development and differentiation. Thus, the dysregulation of proper long-range chromatin interactions may influence the development of tumorigenesis and cancer progression.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- CTCF as a multifunctional protein in genome regulation and gene expression
- Identification of hRad21-Binding Sites in Human Chromosome
- CCCTC-binding factor is essential to the maintenance and quiescence of hematopoietic stem cells in mice
- A Korean case of CTCF related neurodevelopmental disorders
- Correlation of human sperm chromatin heterogeneity with sperm penetration assay
