Genomics Inform.
2013 Jun;11(2):60-67. 10.5808/GI.2013.11.2.60.
Human Transcriptome and Chromatin Modifications: An ENCODE Perspective
- Affiliations
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- 1Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA.
- 2Department of Genetics, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA. wonk@mail.med.upenn.edu
- KMID: 1494258
- DOI: http://doi.org/10.5808/GI.2013.11.2.60
Abstract
- A decade-long project, led by several international research groups, called the Encyclopedia of DNA Elements (ENCODE), recently released an unprecedented amount of data. The ambitious project covers transcriptome, cistrome, epigenome, and interactome data from more than 1,600 sets of experiments in human. To make use of this valuable resource, it is important to understand the information it represents and the techniques that were used to generate these data. In this review, we introduce the data that ENCODE generated, summarize the observations from the data analysis, and revisit a computational approach that ENCODE used to predict gene expression, with a focus on the human transcriptome and its association with chromatin modifications.
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