- Human Transcriptome and Chromatin Modifications: An ENCODE Perspective
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Shen L, Choi I, Nestler EJ, Won KJ
- KMID: 1494258
- Genomics Inform.
- 2013 Jun;11(2):60-67.
- doi: 10.5808/GI.2013.11.2.60
A decade-long project, led by several international research groups, called the Encyclopedia of DNA Elements (ENCODE), recently released an unprecedented amount of data. The ambitious project covers transcriptome, cistrome, epigenome,... -
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- The Therapeutic Effects of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells on Scleroderma
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Yu Y, Shen L, Xie X, Zhao J, Jiang M
- KMID: 2525413
- Tissue Eng Regen Med.
- 2022 Feb;19(1):141-150.
- doi: 10.1007/s13770-021-00405-5
BACKGROUND: Scleroderma is a multisystem disease in which tissue fibrosis is caused by inflammation and vascular damage. The mortality of scleroderma has remained high due to a lack of effective... -
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- Mite and Booklouse Fauna From Vacuumed Dust Samples From Beijing
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Sun JL, Shen L, Chen J, Yu JM, Yin J
- KMID: 2260689
- Allergy Asthma Immunol Res.
- 2014 May;6(3):257-262.
- doi: 10.4168/aair.2014.6.3.257
A significant-source of allergens come from house dust that contain particles derived from arthropods, molds, and pet dander. This study evaluated mite and booklouse fauna from vacuumed dust samples in... -
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- Serum Magnesium Levels Are Negatively Associated with Obesity and Abdominal Obesity in Type 2 Diabetes Mellitus: A Real-World Study
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Xu MR, Wang AP, Wang YJ, Lu JX, Shen L, Li LX
- KMID: 2561798
- Diabetes Metab J.
- 2024 Nov;48(6):1147-1159.
- doi: 10.4093/dmj.2023.0401
Background: There remains controversy over the relationship between serum magnesium levels and obesity in type 2 diabetes mellitus (T2DM). Therefore, the aim of this study was to assess whether there... -
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- Genomic Characteristics and Its Therapeutic Implications in Breast Cancer Patients with Detectable Molecular Residual Disease
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Zhang S, Jiang Y, Zhou L, Xu J, Zhang G, Shen L, Xu Y
- KMID: 2554343
- Cancer Res Treat.
- 2024 Apr;56(2):538-548.
- doi: 10.4143/crt.2023.1059
Purpose Molecular residual disease (MRD) is the main cause of postoperative recurrence of breast cancer. However, the baseline tumor genomic characteristics and therapeutic implications of breast cancer patients with detectable MRD... -
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- Effects of chronic alcohol exposure on ischemia–reperfusion-induced acute kidney injury in mice: the role of β-arrestin 2 and glycogen synthase kinase 3
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Wang L, Zhu Y, Wang L, Hou J, Gao Y, Shen L, Zhang J
- KMID: 2386967
- Exp Mol Med.
- 2017 Jun;49(6):e347.
- doi: 10.1038/emm.2017.76
Little is known about the effects of chronic alcohol intake on the outcome of acute kidney injury (AKI). Hence, we examined the effects of chronic alcohol intake on the development... -
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- Role of Coflex as an Adjunct to Decompression for Symptomatic Lumbar Spinal Stenosis
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Kumar N, Shah SM, Ng YH, Pannierselvam VK, DasDe S, Shen L
- KMID: 2270370
- Asian Spine J.
- 2014 Apr;8(2):161-169.
- doi: 10.4184/asj.2014.8.2.161
STUDY DESIGN: Prospective cohort study. PURPOSE: To assess whether additional implantation of Coflex following spinal decompression provided better clinical outcomes compared to decompression alone for symptomatic lumbar spinal stenosis (LSS) and... -
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- Is transurethral needle ablation of prostate out of fashion? Outcomes of single session office-based transurethral needle ablation of prostate in patients with symptomatic benign prostatic hyperplasia
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Law YX, Chen WJ, Shen L, Chua WJ
- KMID: 2455962
- Investig Clin Urol.
- 2019 Sep;60(5):351-358.
- doi: 10.4111/icu.2019.60.5.351
PURPOSE: Transurethral needle ablation (TUNA) is a minimally invasive procedure for the treatment of symptomatic benign prostatic hyperplasia (BPH). Compared to transurethral resection of the prostate (TURP), office-based TUNA is... -
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- The Role of Peripheral Cannabinoid Receptors Type 1 in Rats With Visceral Hypersensitivity Induced by Chronic Restraint Stress
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Shen L, Yang XJ, Qian W, Hou XH
- KMID: 2326162
- J Neurogastroenterol Motil.
- 2010 Jul;16(3):281-290.
BACKGROUND/AIMS: This study was designed to investigate the possibility that the enhanced nociceptive responsiveness associated with canabonoid type 1 receptors (CB1Rs) and identify its role in mediating visceral hypersensitivity induced... -
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- Trastuzumab Combined with Irinotecan in Patients with HER2-Positive Metastatic Colorectal Cancer: A Phase II Single-Arm Study and Exploratory Biomarker Analysis
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Xu T, Wang X, Xin Y, Wang Z, Gong J, Zhang X, Li Y, Ji C, Sun Y, Zhao F, Huang D, Bai Y, Li J, Shen L
- KMID: 2541249
- Cancer Res Treat.
- 2023 Apr;55(2):626-635.
- doi: 10.4143/crt.2022.1058
Purpose The human epidermal growth factor receptor 2 (HER2) is an established therapeutic target for various kinds of solid tumors. HER2 amplification occurs in approximately 1% to 6% of colorectal... -
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- Asian Consensus Guidelines for the Diagnosis and Management of Gastrointestinal Stromal Tumor
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Koo DH, Ryu MH, Kim KM, Yang HK, Sawaki A, Hirota S, Zheng J, Zhang B, Tzen CY, Yeh CN, Nishida T, Shen L, Chen LT, Kang YK
- KMID: 2356218
- Cancer Res Treat.
- 2016 Oct;48(4):1155-1166.
- doi: 10.4143/crt.2016.187
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors originating in the gastrointestinal tract. With the introduction of molecular-targeted therapy for GISTs which has yielded remarkable outcomes, these tumors... -
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