Korean J Dermatol.  2008 Oct;46(10):1419-1423.

A Case of CD30 (+)/ALK (-) Primary Systemic AnaplasticLarge Cell Lymphoma with Atypical Clinical Features

• Yang YS
• Jeong KH
• Cho HR
• Haw CR
• Kim NI

Abstract

Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin's lymphoma, and this tumor is predominantly composed of large lymphoid cells that have a strong expression of CD30. Two major groups of ALCL have been described. The first is a spectrum of CD30+ lymphoproliferative disorders, including primary cutaneous ALCL and lymphomatoid papulosis. The second is systemic nodal ALCL, which can be subdivided into two groups: anaplastic lymphoma kinase (ALK)-positive and ALK-negative. The relative frequency of ALCL in Korea is about 19% of all cutaneous lymphomas. Solitary or multiple large nodular tumoral lesions confined to one body compartment are the most common presentation. We report here on a case of CD30 (+)/ALK (-) primary systemic ALCL in a 77 year-old-male, and the skin lesion manifested as multiple papules, plaques and tumors on the trunk, buttocks and upper and lower extremities.

Keyword

ALK; Anaplastic large cell lymphoma; CD30; Primary systemic ALCL

MeSH Terms

Buttocks
Korea
Lower Extremity
Lymphocytes
Lymphoma
Lymphoma, Large-Cell, Anaplastic
Lymphoma, Non-Hodgkin
Lymphomatoid Papulosis
Lymphoproliferative Disorders
Phosphotransferases
Receptor Protein-Tyrosine Kinases
Skin
Phosphotransferases
Receptor Protein-Tyrosine Kinases