Korean J Med.  2012 Nov;83(5):674-678.

A Case of Anaplastic Lymphoma Kinase-Negative Primary Gastric Anaplastic Large Cell Lymphoma

• Kim HS
• Park KW
• Lee JL
• Bae SH
• Do WS
• Kim MY
• Lee SA

Abstract

Primary malignant lymphoma of the stomach comprises 1 to 7% of all gastric malignancies and is mostly B-cell type. Anaplastic large cell lymphoma (ALCL) of the stomach is very rare and regarded to have a poor prognosis. A 66-year-old man complained of dyspepsia for 3 days. A esophagogastroduodenoscopic examination revealed a flat, depressed ulcer at the distal antrum. Biopsy of the lesion showed diffuse infiltration of large pleomorphic lymphoid cells that were positive for CD3 and CD30 and negative for cytokeratin and anaplastic lymphoma kinase (ALK). We diagnosed the patient with ALK-negative primary gastric ALCL with multiple lymphadenopathies, and he received systemic chemotherapy. CHOP-like regimens followed by consolidation therapy have been widely used for ALK-negative ALCL. However, the patient maintained complete remission for 36 months with only induction chemotherapy. This case suggests that heavy treatment for ALK-negative ALCL is not required for all patients.

Keyword

Lymphoma, large-cell, anaplastic; Anaplastic lymphoma kinase

MeSH Terms

Aged
B-Lymphocytes
Biopsy
Dyspepsia
Humans
Induction Chemotherapy
Keratins
Lymphocytes
Lymphoma
Lymphoma, Large-Cell, Anaplastic
Phosphotransferases
Prognosis
Receptor Protein-Tyrosine Kinases
Stomach
Ulcer
Keratins
Phosphotransferases
Receptor Protein-Tyrosine Kinases