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Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity

Nishida M, Tanaka T, Mangmool S, Nishiyama , Nishimura

Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative (synthetic) and fully...
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The Function of the Vitamin D Receptor and a Possible Role of Enhancer RNA in Epigenomic Regulation of Target Genes: Implications for Bone Metabolism

Sawatsubashi S, Nishimura , Mori J, Kouzmenko , Kato S

Vitamin D (VD) is essential for bone health, and VD or its analogues are widely used in clinics to ameliorate bone loss. The targets and mode of VD anti-osteoporotic actions...
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Clinical utility of CA-125 in the management of uterine carcinosarcoma

Matsuo K, Ross MS, Yunokawa M, Johnson MS, Machida H, Omatsu K, Klobocista MM, Im DD, Satoh S, Baba T, Ikeda Y, Bush SH, Hasegawa K, Blake EA, Takekuma M, Shida M, Nishimura , Adachi S, Pejovic T, Takeuchi S, Yokoyama T, Ueda Y, Iwasaki K, Miyake TM, Yanai S, Nagano T, Takano T, Shahzad MM, Ueland FR, Kelley JL, Roman LD

No abstract available.
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Postoperative Radiographic Early-Onset Adjacent Segment Degeneration after Single-Level L4–L5 Posterior Lumbar Interbody Fusion in Patients without Preoperative Severe Sagittal Spinal Imbalance

Matsuoka Y, Endo K, Suzuki H, Sawaji Y, Nishimura , Takamatsu , Kojima O, Murata K, Seki T, Horie S, Konishi T, Yamamoto K

STUDY DESIGN: Retrospective study. PURPOSE: To investigate the relationship between preoperative total spinal sagittal alignment and the early onset of adjacent segment degeneration (ASD) after single-level posterior lumbar interbody fusion (PLIF)...
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T-Helper Type 2 Cells Direct Antigen-Induced Eosinophilic Skin Inflammation in Mice

Kaminuma O, Nishimura , Kitamura N, Saeki M, Hiroi T, Mori A

Eosinophilic inflammation in combination with immunoglobulin E (IgE) production is a characteristic feature of atopic dermatitis. Although activated T-helper type (Th) 2 cells play critical roles in the local accumulation...
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Cytokeratin 13, Cytokeratin 17, and Ki-67 Expression in Human Acquired Cholesteatoma and Their Correlation With Its Destructive Capacity

Hamed MA, Nakata S, Shiogama K, Suzuki K, Sayed RH, Nishimura , Iwata N, Sakurai K, Badawy BS, Inada K, Tsuge H, Tsutsumi Y

OBJECTIVES: Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity. Continued research is...
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Closed Wedge Distal Femoral Osteotomy with a Polyaxial Locking Plate Designed for the Proximal Tibia: Minimum 5-Year Outcomes

Nakamura R, Fujita K, Omi R, Kuroda K, Takahashi , Ikebuchi K, Nishimura , Katsuki Y

Since distal femoral varus osteotomy (DFO) -specific plates had not been available in Japan before 2015, we performed DFO using a plate for tibia. The purpose of this study was...
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Regulation of Cartilage Development and Diseases by Transcription Factors

Nishimura , Hata K, Takahata Y, Murakami T, Nakamura E, Yagi H

Genetic studies and molecular cloning approaches have been successfully used to identify several transcription factors that regulate the numerous stages of cartilage development. Sex-determining region Y (SRY)-box 9 (Sox9) is...
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Transcriptional Network Controlling Endochondral Ossification

Hata K, Takahata Y, Murakami T, Nishimura

Endochondral ossification is the fundamental process of skeletal development in vertebrates. Chondrocytes undergo sequential steps of differentiation, including mesenchymal condensation, proliferation, hypertrophy, and mineralization. These steps, which are required for...
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Biomechanical Analysis of a Pedicle Screw-Rod System with a Novel Cross-Link Configuration

Nakajima Y, Hara M, Umebayashi D, Haimoto S, Yamamoto Y, Nishimura , Wakabayashi T

STUDY DESIGN: The strength effects of a pedicle screw-rod system supplemented with a novel cross-link configuration were biomechanically evaluated in porcine spines. PURPOSE: To assess the biomechanical differences between a conventional...
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Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Hamed MA, Nakata S, Sayed RH, Ueda H, Badawy BS, Nishimura , Kojima T, Iwata N, Ahmed AR, Dahy K, Kondo N, Suzuki K

Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result,...
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The Association of Fever with Total Mechanical Ventilation Time in Critically Ill Patients

Park DW, Egi M, Nishimura , Chang Y, Suh GY, Lim CM, Kim JY, Tada K, Matsuo K, Takeda S, Tsuruta R, Yokoyama T, Kim SO, Koh Y, Fever and Antipyretic in Critically ill patients Evaluation (FACE) Study Group in Japan-Korea Intensive Care Study (JAKOICS) Group

This research aims to investigate the impact of fever on total mechanical ventilation time (TVT) in critically ill patients. Subgroup analysis was conducted using a previous prospective, multicenter observational study....
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The predictive variable regarding relapse in patients with ulcerative colitis after achieving endoscopic mucosal healing

Yoshino T, Yamakawa K, Nishimura , Watanabe K, Yazumi S

BACKGROUND/AIMS: Mucosal healing (MH) is a proposed therapeutic goal for patients with ulcerative colitis (UC). Whether MH is the final goal for UC, however, remains under debate. Therefore, to elucidate...
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Gait Analysis in Cervical Spondylotic Myelopathy

Nishimura , Endo K, Suzuki H, Tanaka H, Shishido T, Yamamoto K

STUDY DESIGN: Gait analysis of patients with cervical spondylotic myelopathy (CSM) by using a sheet-type gait analysis system. PURPOSE: The aim of this study was to compare the gait patterns of...
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Current status of robotic surgery in Japan

Nishimura

The da Vinci S surgical system (Intuitive Surgical) was approved as a medical device in 2009 by the Japanese Ministry of Health, Labour and Welfare. Robotic surgery has since been...
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Kinematic Analysis of the Cervical Cord and Cervical Canal by Dynamic Neck Motion

Endo K, Suzuki H, Nishimura , Tanaka H, Shishido T, Yamamoto K

STUDY DESIGN: Normal cervical sagittal length patterns were measured by magnetic resonance imaging (MRI). PURPOSE: The aim of this study was to evaluate the relationship of sagittal length patterns between the...
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Characteristics of Sagittal Spino-Pelvic Alignment in Japanese Young Adults

Endo K, Suzuki H, Nishimura , Tanaka H, Shishido T, Yamamoto K

STUDY DESIGN: Radiological analysis of normal patterns of sagittal alignment of the spine. PURPOSE: This study aimed to clarify the characteristics of normal sagittal spino-pelvic alignment in Asian people. OVERVIEW OF LITERATURE:...
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A Morphologically Atypical Case of Atlantoaxial Rotatory Subluxation

Umebayashi D, Hara M, Nishimura , Wakabayashi T

A rare case of atlantoaxial rotatory subluxation occurred after pediatric cervical spine surgery performed to remove a dumbbell-shaped meningioma at the level of the C1/C2 vertebrae. This case is classified...
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Regulation of Intestinal Homeostasis by Innate Immune Cells

Kayama H, Nishimura , Takeda K

The intestinal immune system has an ability to distinguish between the microbiota and pathogenic bacteria, and then activate pro-inflammatory pathways against pathogens for host defense while remaining unresponsive to the...
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Studies on Therapeutic Effects and Pathological Features of an Antithrombin Preparation in Septic Disseminated Intravascular Coagulation Patients

Sakamoto Y, Inoue S, Iwamura T, Yamashita , Nakashima , Nishimura , Koami H, Imahase H, Goto A, Yamada KC, Mashiko K, Yokota H

PURPOSE: Few reports have been made on the therapeutic effects as well as pathological features of an antithrombin preparation in patients diagnosed with septic disseminated intravascular coagulation (DIC) by the...
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