- NADPH oxidase mediated oxidative stress in hepatic fibrogenesis
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Paik YH, Brenner DA
- KMID: 1792602
- Korean J Hepatol.
- 2011 Dec;17(4):251-257.
- doi: 10.3350/kjhep.2011.17.4.251
NADPH oxidase (NOX) is a multicomponent enzyme complex that generates reactive oxygen species (ROS) in response to a wide range of stimuli. ROS is involved as key secondary messengers in... -
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- Cilostazol Attenuates 4-hydroxynonenal-enhanced CD36 Expression on Murine Macrophages via Inhibition of NADPH Oxidase-derived Reactive Oxygen Species Production
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Yun MR, Park HM, Seo KW, Kim CE, Yoon JW, Kim CD
- KMID: 2071658
- Korean J Physiol Pharmacol.
- 2009 Apr;13(2):99-106.
- doi: 10.4196/kjpp.2009.13.2.99
Although anti-atherogenic effects of cilostazol have been suggested, its effects on the expression of SR in macrophages are unclear. This study investigated the role of cilostazol on CD36 expression... -
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- Induction of NADPH oxidases and antioxidant proteins by Porphyromonas gingivalis in KB cells
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Kim MJ, Chung HJ, Park BJ, Park HR, Lee TH
- KMID: 2321614
- J Korean Acad Periodontol.
- 2006 Dec;36(4):863-878.
No abstract available. -
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- Epigallocatechin-3-gallate Regulates NADPH Oxidase Expression in Human Umbilical Vein Endothelial Cells
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Ahn HY, Kim CH, Ha TS
- KMID: 2071701
- Korean J Physiol Pharmacol.
- 2010 Oct;14(5):325-329.
- doi: 10.4196/kjpp.2010.14.5.325
Vascular NADPH oxidase plays a pivotal role in producing superoxide in endothelial cells and thus acts in the initiation and development of inflammatory cardiovascular diseases such as atherosclerosis. Epigallocatechin-3-gallate (EGCG),... -
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- Lignans with NADPH Oxidase 2 (NOX2)-inhibitory Activity from the Fruits of Schisandra chinensis
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Park JM, Pel P, Chin YW, Lee MY
- KMID: 2409611
- Nat Prod Sci.
- 2018 Mar;24(1):59-65.
- doi: 10.20307/nps.2018.24.1.59
An isoform of NADPH oxidase (NOX), NOX2 is a superoxide-generating enzyme involved in diverse pathophysiological events. Although its potential as a therapeutic target has been validated, there is no clinically... -
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- Effect of Apocynin on Acute Lung Injury in Rats Given Interleukin-1alpha Intratracheally
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Lee YM
- KMID: 2319532
- Tuberc Respir Dis.
- 2011 Jun;70(6):482-489.
BACKGROUND: Based on the assertion that apocynin diminishes acute lung injury (ALI) by inhibition of NADPH oxidase, the effect of apocynin was tested in interleukin-1alpha (IL-1)-induced ALI in rats. METHODS: IL-1... -
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- YJI-7 Suppresses ROS Production and Expression of Inflammatory Mediators via Modulation of p38MAPK and JNK Signaling in RAW 264.7 Macrophages
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Oh HJ, Magar TB, Pun NT, Lee Y, Kim EH, Lee ES, Park PH
- KMID: 2429059
- Biomol Ther.
- 2018 Mar;26(2):191-200.
- doi: 10.4062/biomolther.2016.276
Chalcone, (2E)-1,3-Diphenylprop-2-en-1-one, and its synthetic derivatives are known to possess anti-oxidative and anti-inflammatory properties. In the present study, we prepared a novel synthetic chalcone compound, (E)-1-(4-hydroxyphenyl)-3-(2-(trifluoromethoxy)phenyl)prop-2-en-1-one name (YJI-7), and investigated... -
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- Diphenyleneiodonium Inhibits Apoptotic Cell Death of Gastric Epithelial Cells Infected with Helicobacter pylori in a Korean Isolate
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Cho SO, Lim JW, Kim H
- KMID: 2366360
- Yonsei Med J.
- 2015 Jul;56(4):1150-1154.
- doi: 10.3349/ymj.2015.56.4.1150
NADPH oxidase produces a large amount of reactive oxygen species (ROS) in Helicobacter pylori (H. pylori)-induced gastric epithelial cells. Even though ROS mediate apoptotic cell death, direct involvement of NADPH... -
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- Calyculin A modulates activation of the NADPH-oxidase in Me2SO-differentiated HL-60 cells
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Park JI, Uhlinger D, Chung BS, Kim IH, Kwak JY
- KMID: 755011
- Exp Mol Med.
- 1998 Dec;30(4):214-220.
Human promyelocytic leukemia cells (HL-60) have been used as a model system in which to study the effects of protein phosphatase inhibitors on NADPH-oxidase activation. Since O2- is generated by... -
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- 5-aminoimidazole-4-carboxamide Riboside Induces Apoptosis Through AMP-activated Protein Kinase-independent and NADPH Oxidase-dependent Pathways
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Wi SM, Lee KY
- KMID: 2391720
- Immune Netw.
- 2014 Oct;14(5):241-248.
- doi: 10.4110/in.2014.14.5.241
It is debatable whether AMP-activated protein kinase (AMPK) activation is involved in anti-apoptotic or pro-apoptotic signaling. AICAR treatment increases AMPK-alpha1 phosphorylation, decreases intracellular reactive oxygen species (ROS) levels, and significantly... -
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- p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases
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El-Benna J, Dang PM, Gougerot-Pocidalo MA, Marie JC, Braut-Boucher F
- KMID: 1088596
- Exp Mol Med.
- 2009 Apr;41(4):217-225.
- doi: 10.3858/emm.2009.41.4.058
Phagocytes such as neutrophils play a vital role in host defense against microbial pathogens. The anti-microbial function of neutrophils is based on the production of superoxide anion (O2(.-)), which generates... -
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- Chronic Granulomatous Disease on Jeju Island, Korea
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Cho M, Shin KS
- KMID: 2055571
- J Genet Med.
- 2013 Jun;10(1):1-6.
- doi: 10.5734/JGM.2013.10.1.1
Chronic granulomatous disease (CGD) is a rare inherited disorder of a defective NADPH oxidase enzyme, resulting in very low or no production of superoxide and subsequent reactive oxygen species. Consequently,... -
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- Phagocytosis induces superoxide formation and apoptosis in macrophages
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Park JB
- KMID: 1093604
- Exp Mol Med.
- 2003 Oct;35(5):325-335.
Phagocytosis by inflammatory cells is an essential step and a part of innate immunity for protection against foreign pathogens, microorganism or dead cells. Phagocytosis, endocytotic events sequel to binding particle... -
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- Native low-density lipoprotein-induced superoxide anion contributes to proliferation of human aortic smooth muscle cells
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Lim HK, Shin W, Lee JY, Ryoo S
- KMID: 2092250
- Korean J Anesthesiol.
- 2009 Nov;57(5):622-628.
- doi: 10.4097/kjae.2009.57.5.622
BACKGROUND: Native low-density lipoprotein (nLDL) was one of the modifiable risk factors contributed directly to cardiovascular diseases development. We investigated that nLDL stimulation induced NADPH oxidase activation and superoxide production... -
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- NADPH Oxidase 1 and NADPH Oxidase 4 Have Opposite Prognostic Effects for Patients with Hepatocellular Carcinoma after Hepatectomy
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Ha SY, Paik YH, Yang JW, Lee MJ, Bae H, Park CK
- KMID: 2412082
- Gut Liver.
- 2016 Sep;10(5):826-835.
- doi: 10.5009/gnl15543
BACKGROUND/AIMS: Nicotinamide adenine dinucleotide phosphate oxidase (NOX)-mediated reactive oxygen species contribute to various liver diseases, including hepatocellular carcinoma (HCC). Uncertainties remain regarding the prognostic relevance of NOX1 and NOX4 protein... -
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- Involvement of Vascular NAD(P)H Oxidase-derived Superoxide in Cerebral Vasospasm after Subarachnoid Hemorrhage in Rats
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Kim DE, Kim CD
- KMID: 1614853
- Korean J Physiol Pharmacol.
- 2002 Feb;6(1):15-20.
The role of vascular NAD(P)H oxidase in subarachnoid hemorrhage (SAH)-induced vasospasm in the basilar artery was examined in a rat model. Arterial vasospasm characterized by increased wall thickness and decreased... -
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- Effects of N-Acetylcysteine on Nicotinamide Dinucleotide Phosphate Oxidase Activation and Antioxidant Status in Heart, Lung, Liver and Kidney in Streptozotocin-Induced Diabetic Rats
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Lei S, Liu Y, Liu H, Yu H, Wang H, Xia Z
- KMID: 1120195
- Yonsei Med J.
- 2012 Mar;53(2):294-303.
- doi: 10.3349/ymj.2012.53.2.294
PURPOSE: Hyperglycemia increases reactive oxygen species (ROS) and the resulting oxidative stress plays a key role in the pathogenesis of diabetic complications. Nicotinamide dinucleotide phosphate (NADPH) oxidase is one of... -
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- Efficacy of Diphenyleneiodonium Chloride (DPIC) Against Diverse Plant Pathogens
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Jung B, Li T, Ji S, Lee J
- KMID: 2455605
- Mycobiology.
- 2019 Mar;47(1):105-111.
- doi: 10.1080/12298093.2018.1559122
Many of the fungicides and antibiotics currently available against plant pathogens are of limited use due to the emergence of resistant strains. In this study, we examined the effects of... -
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- Thyroid and Hydrogen Peroxide
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Park DJ
- KMID: 2168208
- Hanyang Med Rev.
- 2012 Nov;32(4):187-191.
- doi: 10.7599/hmr.2012.32.4.187
The thyroid gland produces high concentrations of hydrogen peroxide (H2O2) which is used for the biosynthesis of the thyroid hormones, triiodothyronine and thyroxine. The most important step in thyroid hormone... -
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- Cerulein Pancreatitis: Oxidative Stress, Inflammation, and Apoptosis
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Kim H
- KMID: 2135123
- Gut Liver.
- 2008 Sep;2(2):74-80.
Cerulein pancreatitis is similar to human edematous pancreatitis, manifesting with dysregulation of digestive enzyme production and cytoplasmic vacuolization, the death of acinar cells, edema formation, and infiltration of inflammatory cells... -
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