Korean J Hepatol.  2011 Dec;17(4):251-257. 10.3350/kjhep.2011.17.4.251.

NADPH oxidase mediated oxidative stress in hepatic fibrogenesis

• Paik YH
• Brenner DA

• KMID: 1792602
• DOI: http://doi.org/10.3350/kjhep.2011.17.4.251

Abstract

NADPH oxidase (NOX) is a multicomponent enzyme complex that generates reactive oxygen species (ROS) in response to a wide range of stimuli. ROS is involved as key secondary messengers in numerous signaling pathways, and NADPH oxidases complex has been increasingly recognized as key elements of intracellular signaling of hepatic fibrogenesis. In the liver, NADPH oxidase is functionally expressed both in the phagocytic form and in the non-phagocytic form. The non-phagocytic NADPH oxidase complex is structurally and functionally similar to the phagocytic NADPH, resulting in reduction of molecular oxygen to generate superoxide. There are six homologous NOX proteins in the non-phagocytic forms of NADPH oxidase. An emerging concept is that both phagocytic and nonphagocytic NADPH oxidase components in hepatic stellate cells (HSCs) mediate hepatic fibrosis, suggesting its potential role as a pharmacological target for anti-fibrotic therapy. The molecular components and signaling pathways of various NADPH oxidase homologues that are critical for the fibrotic activity in HSCs need to be more clearly identified.

Keyword

NADPH oxidase; Reactive oxygen species; Oxidative stress; Hepatic fibrosis; Hepatic stellate cell

MeSH Terms

Angiotensin II/metabolism
Hepatic Stellate Cells/metabolism
Humans
Liver Cirrhosis/*enzymology/pathology
NADPH Oxidase/*metabolism
Oxidative Stress
Reactive Oxygen Species/metabolism