- Intercellular Lipid Mediators and GPCR Drug Discovery
-
Im DS
- KMID: 2170658
- Biomol Ther.
- 2013 Nov;21(6):411-422.
G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets.... -
- CITED
-
- Close
- SHARE
-
- Close
- Mechanism of Angiotensin 2-Stimulated Aldosterone Secretion in Adrenal Glomerulosa Cells of Diabetic Rats ; Normal Phospholipase Activity and Intracellular Calcium Mobilization
-
Sung YA, Kyung NH
- KMID: 2331064
- J Korean Soc Endocrinol.
- 1997 Jun;12(2):230-244.
BACKGROUND: Diabetic patients develop hypoaldosteronism which frequently caused hyperkalemia and metabolic acidosis and diabetic hypoaldosteronism is associated with selective unresponsiveness of aldosterone to angiotensin A-II, but mechanism of defect in... -
- CITED
-
- Close
- SHARE
-
- Close
- Lysophosphatidic Acid-Induced TWIST1 and Slug Expression in Oral Cancer Cell Invasion
-
Cho KH
- KMID: 2394692
- J Dent Hyg Sci.
- 2017 Oct;17(5):433-438.
- doi: 10.17135/jdhs.2017.17.5.433
Relative to its incidence, oral cancer has serious negative social effects. The exact causes of oral cancer have not been clarified, but many studies have implicated smoking and drinking. However,... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of STAT3 on Lysophosphatidic Acid-Induced Oral Cancer Cell Invasion
-
Song ZH, Cho KH, Kim JY, Lee HY
- KMID: 2451792
- J Dent Hyg Sci.
- 2019 Jun;19(2):141-146.
- doi: 10.17135/jdhs.2019.19.2.141
BACKGROUND: Oral cancer has a high incidence worldwide and has been closely associated with smoking, alcohol, and infection by the human papillomavirus. Metastasis is highly important for oral cancer survival.... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Sphingosine-1-Phosphate on Neural Differentiation and Neurite Outgrowth in Neuroblastoma Cells
-
Lee JH, Jang S, Jeong HS, Park JS
- KMID: 2172241
- Chonnam Med J.
- 2011 Apr;47(1):27-30.
- doi: 10.4068/cmj.2011.47.1.27
Sphingosine-1-phosphate (S1P) is emerging as a new class of second messenger involved in cellular proliferation, differentiation, and apoptosis and is implicated in diverse physiological functions. Despite many studies on the... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of Resveratrol on Oral Cancer Cell Invasion Induced by Lysophosphatidic Acid
-
Kim JY, Cho KH, Lee HY
- KMID: 2415284
- J Dent Hyg Sci.
- 2018 Jun;18(3):188-193.
- doi: 10.17135/jdhs.2018.18.3.188
The aim of the current study was to demonstrate the potential therapeutic efficacy of resveratrol in oral cancer patients. Lysophosphatidic acid (LPA) intensifies cancer cell invasion and metastasis, whereas resveratrol,... -
- CITED
-
- Close
- SHARE
-
- Close
- Prolonged ERK Activation of S1P on B16 Melanoma Cells
-
Lee HS, Choi GS, Shin JH
- KMID: 2248133
- Korean J Dermatol.
- 2008 Jun;46(6):769-775.
BACKGROUND: The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), was reported to induce apoptosis of some cancer cells and neurons, although it is generally known to exert mitogenic and antiapoptotic effects.... -
- CITED
-
- Close
- SHARE
-
- Close
- Association of Bone Marrow Sphingosine 1-phosphate Levels with Osteoporotic Hip Fractures
-
Ahn SH, Koh JM, Gong EJ, Byun S, Lee SY, Kim BJ, Lee SH, Chang JS, Kim GS
- KMID: 2286295
- J Bone Metab.
- 2013 Nov;20(2):61-65.
- doi: 10.11005/jbm.2013.20.2.61
BACKGROUND: Sphingosine 1-phosphate (S1P) has been discovered to be a critical regulator of bone metabolism. Very recently, we found that higher circulating S1P levels were associated with higher rate of... -
- CITED
-
- Close
- SHARE
-
- Close
- The Effect of Sphingosine-1-Phosphate in Survival of Grafted Fat Tissues
-
Yoon DJ, Choi SJ, Choi CW, Nam SB, Bae YC
- KMID: 2120569
- J Korean Soc Plast Reconstr Surg.
- 2010 Nov;37(6):726-731.
PURPOSE: Autologous fat grafting is a popular procedure for the correction of the soft tissue depression and deformity. But there are several issues required to be carefully considered in relation... -
- CITED
-
- Close
- SHARE
-
- Close
- The Phospholipid Linoleoylglycerophosphocholine as a Biomarker of Directly Measured Insulin Resistance
-
Pérez-Matos MC, Morales-Ãlvarez MC, Toloza FJ, Ricardo-Silgado ML, Mantilla-Rivas JO, Pinzón-Cortes JA, Perez-Mayorga M, Jiménez E, Guevara E, Mendivil C
- KMID: 2398087
- Diabetes Metab J.
- 2017 Dec;41(6):466-473.
- doi: 10.4093/dmj.2017.41.6.466
BACKGROUND: Plasma concentrations of some lysophospholipids correlate with metabolic alterations in humans, but their potential as biomarkers of insulin resistance (IR) is insufficiently known. We aimed to explore the association... -
- CITED
-
- Close
- SHARE
-
- Close
- Dietary effect of silk protein on epidermal levels of free sphingoid bases and phosphate metabolites in NC/Nga mice
-
Kim Y, Song EH, Shin K, Lee Y, Cho Y
- KMID: 2268660
- Korean J Nutr.
- 2012 Apr;45(2):113-120.
- doi: 10.4163/kjn.2012.45.2.113
In our previous studies, dietary supplements of silk protein, sericin, and fibroin, were beneficial for improving epidermal levels of ceramides, which are the major lipids for maintaining the epidermal barrier.... -
- CITED
-
- Close
- SHARE
-
- Close
- Protective Effects of K6PC-5, A Sphingosine Kinase Activator, Against 1-methyl-4-phenylpyridinium-induced Dopaminergic Neuronal Cell Death
-
Jang S, Choi SS, Kim SH, Park JS, Jeong HS
- KMID: 2172296
- Chonnam Med J.
- 2008 Dec;44(3):162-168.
- doi: 10.4068/cmj.2008.44.3.162
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metaolite, regulates multiple cellular responses such as Ca2+ signaling, cellular growth and survival, and differentiation. Sphingosine kinase (SphK) is a key enzyme in modulating the... -
- CITED
-
- Close
- SHARE
-
- Close
- Comparison of total plasma lysophosphatidic acid and serum CA-125 as a tumor marker in the diagnosis and follow-up of patients with epithelial ovarian cancer
-
Bese T, Barbaros M, Baykara E, Guralp O, Cengiz S, Demirkiran F, Sanioglu C, Arvas M
- KMID: 2173549
- J Gynecol Oncol.
- 2010 Dec;21(4):248-254.
- doi: 10.3802/jgo.2010.21.4.248
OBJECTIVE: To evaluate the role of lysophosphatidic acid (LPA) as a tumor marker in diagnosis and follow-up of patients with epithelial ovarian cancer. METHODS: Eighty-seven epithelial ovarian cancer patients, 74 benign... -
- CITED
-
- Close
- SHARE
-
- Close
- Activation of Lysophosphatidic Acid Receptor Is Coupled to Enhancement of Ca(2+)-Activated Potassium Channel Currents
-
Choi SH, Lee BH, Kim HJ, Hwang SH, Lee SM, Nah SY
- KMID: 1429302
- Korean J Physiol Pharmacol.
- 2013 Jun;17(3):223-228.
- doi: 10.4196/kjpp.2013.17.3.223
The calcium-activated K+ (BKCa) channel is one of the potassium-selective ion channels that are present in the nervous and vascular systems. Ca2+ is the main regulator of BKCa channel activation.... -
- CITED
-
- Close
- SHARE
-
- Close
- Metabolomic Study of a Diagnostic Model for the Metabolites of Stool Fat
-
Lee CH, Kim J, Ahn SY, Lee SY
- KMID: 1775781
- Korean J Gastroenterol.
- 2013 Jan;61(1):9-16.
- doi: 10.4166/kjg.2013.61.1.9
BACKGROUND/AIMS: Metabolomics is a powerful tool for measuring low-molecular-weight metabolites in an organism at a specified time under specific environmental conditions. The aim of this study was to determine the... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of LPA and the Hippo pathway on apoptosis in salivary gland epithelial cells
-
Hwang SM, Jin M, Shin YH, Ki Choi S, Namkoong E, Kim M, Park MY, Park K
- KMID: 2155390
- Exp Mol Med.
- 2014 Dec;46(12):e125.
- doi: 10.1038/emm.2014.77
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid involved in numerous physiological responses. However, the expression of LPA receptors and the role of the Hippo signaling pathway in epithelial cells have... -
- CITED
-
- Close
- SHARE
-
- Close
- The Effects of Nitric Oxide and Sphingosine 1-phosphate on the Pulmonary Microstructure in a Rat Model of Acute Lung Injury: An Intravital Videomicroscopic Approach
-
Lee JI, Jheon S, Sung SW, Kim JH
- KMID: 1491177
- Korean J Thorac Cardiovasc Surg.
- 2008 Apr;41(2):177-188.
BACKGROUND: To evaluate the effects of inhaled nitric oxide (NO) and sphingosine 1-phosphate (S1P) as potential therapeutic agents of acute lung injury, we analyzed the morphology in vivo of the... -
- CITED
-
- Close
- SHARE
-
- Close
- Kruppel-like factor 4 mediates lysophosphatidic acid-stimulated migration and proliferation of PC3M prostate cancer cells
-
Shin SH, Kwon YW, Heo SC, Jeong GO, Kim BR, Seo EJ, Kim JH
- KMID: 2155369
- Exp Mol Med.
- 2014 Jul;46(7):e104.
- doi: 10.1038/emm.2014.34
Prostate cancer is the most frequently diagnosed malignancy and the second leading cause of cancer mortality among men in the United States. Accumulating evidence suggests that lysophosphatidic acid (LPA) serves... -
- CITED
-
- Close
- SHARE
-
- Close
- Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1beta production from human phagocytes
-
Shim JW, Jo SH, Kim SD, Lee HY, Yun J, Bae YS
- KMID: 1119324
- Exp Mol Med.
- 2009 Aug;41(8):584-591.
- doi: 10.3858/emm.2009.41.8.064
In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also... -
- CITED
-
- Close
- SHARE
-
- Close
- Sphingosine 1-Phosphate Triggers Apoptotic Signal for B16 Melanoma Cells via ERK and Caspase Activation
-
Shin JH, Choi GS, Kang WH, Myung KB
- KMID: 1713191
- J Korean Med Sci.
- 2007 Apr;22(2):298-304.
- doi: 10.3346/jkms.2007.22.2.298
The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), recently was reported to induce apoptosis of some cancer cells and neurons, although it generally known to exert mitogenic and antiapoptotic effects. In... -
- CITED
-
- Close
- SHARE
-
- Close
