Exp Mol Med.  2009 Aug;41(8):584-591. 10.3858/emm.2009.41.8.064.

Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1beta production from human phagocytes

• Shim JW
• Jo SH
• Kim SD
• Lee HY
• Yun J
• Bae YS

• KMID: 1119324
• DOI: http://doi.org/10.3858/emm.2009.41.8.064

Abstract

In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1beta production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1beta production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.

Keyword

cell migration inhibition; chemotaxis, leukocyte; interleukin-1beta; lysophosphatidylglycerol; phagocytes; receptors, formyl peptide

MeSH Terms

Chemotaxis, Leukocyte/*drug effects
Humans
Interleukin-1beta/*biosynthesis
Lysophospholipids/*pharmacology
Monocytes/drug effects/immunology/metabolism/physiology
Neutrophils/drug effects/immunology/metabolism/physiology
Peptides/metabolism/pharmacology
*Phagocytes/drug effects/immunology/metabolism/physiology
Receptors, Formyl Peptide/*metabolism
Receptors, Lipoxin/*metabolism
Serum Amyloid A Protein/metabolism/pharmacology