Exp Mol Med.  2017 Aug;49(8):e369. 10.1038/emm.2017.120.

Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling

• Kim JC
• Jung YS
• Lee HY
• Park JS
• Bae YS

• KMID: 2389297
• DOI: http://doi.org/10.1038/emm.2017.120

Abstract

In this study, we report that an acute phase reactant, serum amyloid A (SAA), strongly inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased the expression of MHCII and CD11c. Moreover, SAA decreased cell surface GM-CSF receptor expression. SAA also decreased the expression of PU.1 and C/EBPα, which play roles in the expression of GM-CSF receptor. This inhibitory response by SAA is partly mediated by the well-known SAA receptors, Toll-like receptor 2 and formyl peptide receptor 2. Taken together, we suggest a novel insight into the inhibitory role of SAA in dendritic cell differentiation.

MeSH Terms

Dendritic Cells*
Granulocyte-Macrophage Colony-Stimulating Factor*
Interleukin-4
Receptors, Formyl Peptide
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor*
Serum Amyloid A Protein*
Toll-Like Receptors
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-4
Receptors, Formyl Peptide
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
Serum Amyloid A Protein
Toll-Like Receptors