- Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling
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Kim JC, Jung YS, Lee HY, Park JS, Bae YS
- KMID: 2389297
- Exp Mol Med.
- 2017 Aug;49(8):e369.
- doi: 10.1038/emm.2017.120
In this study, we report that an acute phase reactant, serum amyloid A (SAA), strongly inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased the expression of... -
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- Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1beta production from human phagocytes
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Shim JW, Jo SH, Kim SD, Lee HY, Yun J, Bae YS
- KMID: 1119324
- Exp Mol Med.
- 2009 Aug;41(8):584-591.
- doi: 10.3858/emm.2009.41.8.064
In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also... -
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- Identification of novel peptides that stimulate human neutrophils
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Bae GH, Lee HY, Jung YS, Shim JW, Kim SD, Baek SH, Kwon JY, Park JS, Bae YS
- KMID: 1120131
- Exp Mol Med.
- 2012 Feb;44(2):130-137.
- doi: 10.3858/emm.2012.44.2.008
Neutrophils play a key role in innate immunity, and the identification of new stimuli that stimulate neutrophil activity is a very important issue. In this study, we identified three novel... -
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- Serum amyloid A inhibits RANKL-induced osteoclast formation
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Oh E, Lee HY, Kim HJ, Park YJ, Seo JK, Park JS, Bae YS
- KMID: 2359881
- Exp Mol Med.
- 2015 Nov;47(11):e194.
- doi: 10.1038/emm.2015.83
When mouse bone marrow-derived macrophages were stimulated with serum amyloid A (SAA), which is a major acute-phase protein, there was strong inhibition of osteoclast formation induced by the receptor activator... -
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- Scant Extracellular NAD Cleaving Activity of Human Neutrophils is Down-Regulated by fMLP via FPRL1
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Hasan MA, Sultan MT, Ahn WG, Kim YJ, Jang JH, Hong CW, Song DK
- KMID: 2285552
- Korean J Physiol Pharmacol.
- 2014 Dec;18(6):497-502.
- doi: 10.4196/kjpp.2014.18.6.497
Extracellular nicotinamide adenine dinucleotide (NAD) cleaving activity of a particular cell type determines the rate of the degradation of extracellular NAD with formation of metabolites in the vicinity of the... -
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- The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis
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Kim SD, Kwon S, Lee SK, Kook M, Lee HY, Song KD, Lee HK, Baek SH, Park CB, Bae YS
- KMID: 2154259
- Exp Mol Med.
- 2013 Sep;45(9):e40.
In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases in body... -
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- LL-37 inhibits serum amyloid A-induced IL-8 production in human neutrophils
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Lee HY, Kim SD, Shim JW, Lee SY, Yun J, Bae YS
- KMID: 1123806
- Exp Mol Med.
- 2009 May;41(5):325-333.
- doi: 10.3858/emm.2009.41.5.036
Serum amyloid A (SAA) has been regarded as an important mediator of inflammatory responses. The effect of several formyl peptide receptor-like 1 (FPRL1) ligands on the production of IL-8 by... -
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- Trp-Lys-Tyr-Met-Val-Met stimulates phagocytosis via phospho-lipase D-dependent signaling in mouse dendritic cells
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Lee HY, Kang HK, Jo EJ, Kim JI, Lee YN, Lee SH, Park YM, Ryu SH, Kwak JY, Bae YS
- KMID: 1380208
- Exp Mol Med.
- 2004 Apr;36(2):135-144.
Dendritic cells (DCs) play a key role in activating the immune response against invading pathogens as well as dying cells or tumors. Although the immune response can be initiated by... -
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