Exp Mol Med.
2013 Sep;45(9):e40.
The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis
- Affiliations
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- 1Department of Biological Science, Sungkyunkwan University, Suwon, Korea. yoesik@skku.edu
- 2Mitochondria Hub Regulation Center, College of Medicine, Dong-A University, Busan, Korea.
- 3Genomic Informatics Center, Hankyong National University, Anseong, Korea.
- 4Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, Daegu, Korea.
- 5Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea.
- 6Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea.
Abstract
- In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases in body weight, bleeding score and stool score in addition to reversing DSS-induced mucosa destruction and shortened colon. The WKYMVm-induced therapeutic effect against ulcerative colitis was strongly inhibited by a formyl peptide receptor (FPR) 2 antagonist, WRWWWW, indicating the crucial role of FPR2 in this effect. Mechanistically, WKYMVm effectively decreases intestinal permeability by stimulating colon epithelial cell proliferation. WKYMVm also strongly decreases interleukin-23 and transforming growth factor-beta production in the colon of DSS-treated mice. We suggest that the potent immune-modulating peptide WKYMVm and its receptor FPR2 may be useful in the development of efficient therapeutic agents against chronic intestinal inflammatory diseases.
Keyword
MeSH Terms
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Adjuvants, Immunologic/pharmacology/*therapeutic use
Animals
Caco-2 Cells
Cell Proliferation
Colitis, Ulcerative/*drug therapy/metabolism
Colon/pathology
Humans
Interleukin-23/genetics/metabolism
Intestinal Mucosa/drug effects/metabolism/pathology
Mice
Mice, Inbred C57BL
Oligopeptides/pharmacology/*therapeutic use
Permeability
Receptors, Formyl Peptide/antagonists & inhibitors
Transforming Growth Factor beta/genetics/metabolism
Adjuvants, Immunologic
Interleukin-23
Oligopeptides
Receptors, Formyl Peptide
Transforming Growth Factor beta
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