- The role of E-cadherin expression in non-small cell lung cancer
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Lim SC, Jang IG, Kim YC, Park KO
- KMID: 965869
- J Korean Med Sci.
- 2000 Oct;15(5):501-506.
- doi: 10.3346/jkms.2000.15.5.501
The purpose of this study is to evaluate the clinical significance of E-cadherin expression in lung cancer. E-cadherin expression was detected by immunohistochemistry using a monoclonal antibody (HECD-1). Strongly positive... -
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- Expression of Semaphorin 3A and Neuropilin 1 in Asthma
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Shim EJ, Chun E, Kang HR, Cho SH, Min KU, Park HW
- KMID: 1777678
- J Korean Med Sci.
- 2013 Oct;28(10):1435-1442.
- doi: 10.3346/jkms.2013.28.10.1435
Neuropilin 1 (NP1) is a part of essential receptor complexes mediating both semaphorin3A (SEMA3A) and vascular endothelial growth factor (VEGF) which is one of important mediators involved in the pathogenesis... -
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- MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2
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Cheng Z, Ma R, Tan W, Zhang L
- KMID: 2155377
- Exp Mol Med.
- 2014 Sep;46(9):e112.
- doi: 10.1038/emm.2014.51
MicroRNAs (miRNAs) regulate the proliferation and metastasis of cancer cells. Here, we showed that miR-152 was downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. Overexpression of miR-152 suppressed... -
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- Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Augments Acute Lung Injury via Its Neutrophil Priming Effects
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Choi JC, Jung JW, Kwak HW, Song JH, Jeon EJ, Shin JW, Park IW, Choi BW, Kim JY
- KMID: 1713463
- J Korean Med Sci.
- 2008 Apr;23(2):288-295.
- doi: 10.3346/jkms.2008.23.2.288
Granulocyte macrophage-colony stimulating factor (GM-CSF) has immuno-stimulatory effects. We hypothesized that GM-CSF plays an important role both in lipopolysaccharide (LPS)- and hemorrhage-induced acute lung injury (ALI). We also postulated that... -
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- Differential Expression of Hypoxia Inducible Factor-1 alpha and Tumor Cell Proliferation Between Squamous Cell Carcinomas and Adenocarcinomas Among Operable Non-Small Cell Lung Carcinomas
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Lee CH, Lee MK, Kang CD, Kim YD, Park DY, Kim JY, Sol MY, Suh KS
- KMID: 2157622
- J Korean Med Sci.
- 2003 Apr;18(2):196-203.
- doi: 10.3346/jkms.2003.18.2.196
This study aimed to evaluate whether the elevated level of hypoxia-inducible factor-1 alpha (HIF-1 alpha) correlated with histologic types, angiogenesis, tumor cell proliferation, and clinical parameters in common non-small cell... -
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- Expression of von Willebrand factor, pulmonary intravascular macrophages, and Toll-like receptors in lungs of septic foals
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Harrison J, Quanstrom , Robinson A, Wobeser B, Anderson S, Singh B
- KMID: 2412583
- J Vet Sci.
- 2017 Mar;18(1):17-23.
- doi: 10.4142/jvs.2017.18.1.17
Sepsis causes significant mortality in neonatal foals; however, there is little data describing the cellular and molecular pathways of lung inflammation in septic foals. This study was conducted to characterize... -
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- Angiopoietin-1 Modified Human Umbilical Cord Mesenchymal Stem Cell Therapy for Endotoxin-Induced Acute Lung Injury in Rats
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Huang ZW, Liu N, Li D, Zhang HY, Wang Y, Liu Y, Zhang LL, Ju XL
- KMID: 2374208
- Yonsei Med J.
- 2017 Jan;58(1):206-216.
- doi: 10.3349/ymj.2017.58.1.206
PURPOSE: Angiopoietin-1 (Ang1) is a critical factor for vascular stabilization and endothelial survival via inhibition of endothelial permeability and leukocyte- endothelium interactions. Hence, we hypothesized that treatment with umbilical cord... -
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- Post-mortem re-cloning of a transgenic red fluorescent protein dog
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Hong SG, Koo OJ, Oh HJ, Park JE, Kim M, Kim GA, Park EJ, Jang G, Lee BC
- KMID: 1365026
- J Vet Sci.
- 2011 Dec;12(4):405-407.
- doi: 10.4142/jvs.2011.12.4.405
Recently, the world's first transgenic dogs were produced by somatic cell nuclear transfer. However, cellular senescence is a major limiting factor for producing more advanced transgenic dogs. To overcome this... -
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- Gene Expression Profiles in Genetically Different Mice Infected with Toxoplasma gondii: ALDH1A2, BEX2, EGR2, CCL3 and PLAU
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Ismail HA, Quan JH, Wei Z, Choi IW, Cha GH, Shin DW, Lee YH, Song CJ
- KMID: 1364889
- Korean J Parasitol.
- 2012 Mar;50(1):7-13.
- doi: 10.3347/kjp.2012.50.1.7
Toxoplasma gondii can modulate host cell gene expression; however, determining gene expression levels in intermediate hosts after T. gondii infection is not known much. We selected 5 genes (ALDH1A2, BEX2,... -
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- Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells
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Park HW, Song JY, Kim KS, Han Y, Kim CW, Yi SY, Yun YS
- KMID: 1123762
- Exp Mol Med.
- 2004 Oct;36(5):411-419.
Ceramide generated from sphingomyelin in response to ionizing radiation has been implicated as a second messenger to induce cellular proapoptotic signals. Both ceramide and its metabolic inhibitor, N, N-dimethyl-D-erythro-sphingosine (DMS),... -
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- Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines
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Hong YS, Ham YA, Choi JH, Kim JG
- KMID: 755076
- Exp Mol Med.
- 2000 Sep;32(3):127-134.
Allyl sulfur compounds play a major role in the chemoprevention against carcinogenesis. The present study compared the antiproliferative effects of diallyl sulfide (DAS), diallyl disulfide (DADS) and garlic... -
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- Hot-Clot Artifacts in the Lung Parenchyma on F-18 Fluorodeoxyglucose Positron Emission Tomography/CT due to Faulty Injection Techniques: Two Case Reports
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Ozdemir E, Poyraz NY, Keskin M, Kandemir Z, Turkolmez
- KMID: 1731058
- Korean J Radiol.
- 2014 Aug;15(4):530-533.
- doi: 10.3348/kjr.2014.15.4.530
F-18-fluorodeoxyglucose (FDG) positron emission tomography/CT is an important whole-body imaging tool in the oncology and widely utilized to stage and restage various malignancies. The findings of significant focal accumulation of... -
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- Long-Term (Postnatal Day 70) Outcome and Safety of Intratracheal Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Neonatal Hyperoxic Lung Injury
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Ahn SY, Chang YS, Kim SY, Sung DK, Kim ES, Rime SY, Yu WJ, Choi SJ, Oh WI, Park WS
- KMID: 1503905
- Yonsei Med J.
- 2013 Mar;54(2):416-424.
- doi: 10.3349/ymj.2013.54.2.416
PURPOSE: This study was performed to evaluate the long-term effects and safety of intratracheal (IT) transplantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in neonatal hyperoxic lung injury... -
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- The Role of the Lactate Dehydrogenase and the Effect of Prone Position during Ventilator-induced Lung Injury
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Lim SC, Kim YI
- KMID: 1733481
- J Korean Med Sci.
- 2004 Apr;19(2):223-228.
- doi: 10.3346/jkms.2004.19.2.223
To examine the impact of lactate dehydrogenase (LDH) as an early marker of ventilator-induced lung injury (VILI) and the effect of prone position during the VILI, we ventilated 28 normal... -
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- A 24 kDa Excretory-Secretory Protein of Anisakis simplex Larvae Could Elicit Allergic Airway Inflammation in Mice
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Park HK, Cho MK, Park MK, Kang SA, Kim YS, Kim KU, Lee MK, Ock MS, Cha HJ, Yu HS
- KMID: 1715742
- Korean J Parasitol.
- 2011 Dec;49(4):373-380.
- doi: 10.3347/kjp.2011.49.4.373
We have reported that a 24 kDa protein (22U homologous; As22U) of Anisakis simplex larvae could elicit several Th2-related chemokine gene expressions in the intestinal epithelial cell line which means... -
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- Cathepsin B is activated as an executive protease in fetal rat alveolar type II cells exposed to hyperoxia
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Lee HS, Kim CK
- KMID: 1104392
- Exp Mol Med.
- 2011 Apr;43(4):223-229.
- doi: 10.3858/emm.2011.43.4.027
Alveolar type II cells are main target of hyperoxia-induced lung injury. The authors investigated whether lysosomal protease, cathepsin B (CB), is activated in fetal alveolar type II cells in the... -
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- The Wnt/beta-catenin signaling pathway regulates the development of airway remodeling in patients with asthma
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Kwak HJ, Park DW, Seo JY, Moon JY, Kim TH, Sohn JW, Shin DH, Yoon HJ, Park SS, Kim SH
- KMID: 2359885
- Exp Mol Med.
- 2015 Dec;47(12):e198.
- doi: 10.1038/emm.2015.91
Airway remodeling is a key characteristic of chronic asthma, particularly in patients with a fixed airflow limitation. The mechanisms underlying airway remodeling are poorly understood, and no therapeutic option is... -
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- Imaging Characteristics of Stage I Non-Small Cell Lung Cancer on CT and FDG-PET: Relationship with Epidermal Growth Factor Receptor Protein Expression Status and Survival
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Lee Y, Lee HJ, Kim YT, Kang CH, Goo JM, Park CM, Paeng JC, Chung DH, Jeon YK
- KMID: 1482802
- Korean J Radiol.
- 2013 Apr;14(2):375-383.
- doi: 10.3348/kjr.2013.14.2.375
OBJECTIVE: To identify CT and FDG-PET features associated with epidermal growth factor receptor (EGFR) protein overexpression, and to evaluate whether imaging features and EGFR-overexpression can help predict clinical outcome. MATERIALS AND... -
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- The Effect of Umbilical Cord Blood Derived Mesenchymal Stem Cells in Monocrotaline-induced Pulmonary Artery Hypertension Rats
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Lee H, Lee JC, Kwon JH, Kim KC, Cho MS, Yang YS, Oh W, Choi SJ, Seo ES, Lee SJ, Wang TJ, Hong YM
- KMID: 2155470
- J Korean Med Sci.
- 2015 May;30(5):576-585.
- doi: 10.3346/jkms.2015.30.5.576
Pulmonary arterial hypertension (PAH) causes right ventricular failure due to a gradual increase in pulmonary vascular resistance. The purposes of this study were to confirm the engraftment of human umbilical... -
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- Kinetics of IFN-Gamma and TNF-Alpha Gene Expression and Their Relationship with Disease Progression after Infection with Mycobacterium Tuberculosis in Guinea Pigs
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Roh IS, Cho S, Eum SY, Cho SN
- KMID: 1727887
- Yonsei Med J.
- 2013 May;54(3):707-714.
- doi: 10.3349/ymj.2013.54.3.707
PURPOSE: Guinea pig is one of the most suitable animal models for Mycobacterium tuberculosis (M. tb) infection since it shows similarities to pulmonary infection in humans. Although guinea pig shows... -
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