- Cholesterol conjugated spermine as a delivery modality of antisense oligonucleotide
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Im YK, Kim MS, Yoo H
- KMID: 1709609
- Int J Oral Biol.
- 2013 Dec;38(4):155-160.
The major issue in the development of nucleic acid based therapeutics is the inefficient delivery of these agents into cells. We prepared cholesterol conjugated spermine and evaluated its usefulness as... -
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- Are Podoplanin Gene Polymorphisms Associated with Atopic Dermatitis in Koreans?
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Namkung JH, Kim E, Park YD, Park G, Yang JM
- KMID: 2352498
- Ann Dermatol.
- 2015 Jun;27(3):275-282.
- doi: 10.5021/ad.2015.27.3.275
BACKGROUND: The histologic characteristics of atopic dermatitis (AD) include perivascular edema and dilated tortuous vessels in the papillary dermis. A single nucleotide polymorphism (SNP) of the fms-related tyrosine kinase 4... -
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- Construction of a Mycobacterium - Escherichia coli Shuttle Vector and Use in the Expression of Foreign Genes in Mycobacteria
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Cho SN, Kim JD, Lee HY, Kim HJ
- KMID: 1540524
- J Korean Soc Microbiol.
- 1997 Jun;32(3):293-300.
The ability to introduce recombinant DNA molecules back into mycobacteria would greatly increase the potential of molecular genetic approaches for the study of mycobacteria as well as for the use... -
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- Optical Imaging in the Field of Molecular Imaging
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Roh JK, Kim DE
- KMID: 1936466
- J Korean Med Assoc.
- 2004 Feb;47(2):127-132.
- doi: 10.5124/jkma.2004.47.2.127
Molecular imaging is leading an important role in the era of molecular medicine. Optical imaging, a rising star in the filed of molecular imaging, largely consists of fluorescent imaging and... -
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- Effect of Copper on the Regulation of Ferroportin-1 Gene Expression
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Park BY, Chung J
- KMID: 2267325
- Korean J Nutr.
- 2009 Jul;42(5):434-441.
- doi: 10.4163/kjn.2009.42.5.434
Ferroportin-1 (FPN) is a transporter protein that is known to mediate iron export from macrophages. The purpose of this study was to investigate the effect of copper on the regulation... -
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- TGF - beta Type II Receptor Anomaly and of Its Functional Restoration in Osteosarcoma Cell Lines
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Lee KH, Oh SS, Cha YD, Ko SM, Oh IS, Lee JY, Kim SJ
- KMID: 2336077
- J Korean Orthop Assoc.
- 1998 Jun;33(3):914-919.
TGF-p receptor mutation is now considered as one of the carcinogenic process of many tumors. To evaluate whether there is an abnormality in TGF-p type II receptor in osteosarcoma cell... -
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- Naringenin-Mediated ATF3 Expression Contributes to Apoptosis in Human Colon Cancer
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Song HM, Park GH, Eo HJ, Jeong JB
- KMID: 2170525
- Biomol Ther.
- 2016 Mar;24(2):140-146.
- doi: 10.4062/biomolther.2015.109
Naringenin (NAR) as one of the flavonoids observed in grapefruit has been reported to exhibit an anti-cancer activity. Activating transcription factor 3 (ATF3) is associated with apoptosis in human colon... -
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- Identification of Novel Genetic Variations in the Proximal Promoter of the Human Transporter, OCT2
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Choi JH
- KMID: 1893441
- Ewha Med J.
- 2011 Mar;34(1):9-13.
- doi: 10.12771/emj.2011.34.1.9
OBJECTIVES: Human organic cation transporter 2, OCT2(SLC22A2), highly expressed on the renal proximal tubular cells, plays an important role in the renal excretion of endogenous and exogenous organic cations including... -
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- Marker Gene Transfer into Cells of Rat Achilles Tendon by In Vivo Electroporation
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Park JH, Park JW, Lee KS
- KMID: 2105746
- J Korean Orthop Assoc.
- 2001 Jun;36(3):221-226.
PURPOSE: To demonstrate and analyze quantitatively the expression of marker genes in the Achilles tendon of rats by direct DNA injection and electroporation. MATERIALS AND METHODS: Enhanced green fluorescent protein... -
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- The Activation of PPAR-α and Wnt/β-catenin by Luffa cylindrica Supercritical Carbon Dioxide Extract
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Kim B
- KMID: 2468068
- Nat Prod Sci.
- 2019 Dec;25(4):341-347.
- doi: 10.20307/nps.2019.25.4.341
Luffa cylindrica (LC) is a very fast-growing climber and its fruit have been considered as agricultural wastes. We conducted to check the comparative qualities of ethanol solvent extraction (LCE) and... -
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- Differential Expression of STATs and Its Function in Osteogenesis of Mesenchymal Stem Cells
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Hwang JS, Lee KM, Jung HS, Lee JW, Choi YR
- KMID: 1498972
- J Korean Orthop Res Soc.
- 2013 Jun;16(1):1-9.
PURPOSE: To investigate the role of STAT5 during osteogenesis differentiation of human mesenchymal stem cells(hMSC). MATERIALS AND METHODS: To assess the expression pattern of STATs during osteogenic differentiation, we performed western... -
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- Activation of Nuclear Factor Kappa B by Inducers in Gestational Tissues at Term
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Kim JH, Kim YA, Yang SH
- KMID: 2272158
- Korean J Obstet Gynecol.
- 2003 Sep;46(9):1736-1740.
OBJECTIVE: Nuclear factor kappa B (NF-kappa B) is a transcriptional factor in the expression of cyclooxygenase 2 (COX-2), the key enzyme in production of prostaglandins. The purpose of this study... -
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- Identification and Functional Characterization of Novel Genetic Variations in the OCTN1 Promoter
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Park HJ, Choi JH
- KMID: 2285507
- Korean J Physiol Pharmacol.
- 2014 Apr;18(2):169-175.
- doi: 10.4196/kjpp.2014.18.2.169
Human organic cation/carnitine transporter 1 (OCTN1) plays an important role in the transport of drugs and endogenous substances. It is known that a missense variant of OCTN1 is significantly associated... -
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- Inhibition of Wnt Signaling by Silymarin in Human Colorectal Cancer Cells
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Eo HJ, Park GH, Jeong JB
- KMID: 2351686
- Biomol Ther.
- 2016 Jul;24(4):380-386.
- doi: 10.4062/biomolther.2015.154
Silymarin from milk thistle (Silybum marianum) has been reported to show an anti-cancer activity. In previous study, we reported that silymarin induces cyclin D1 proteasomal degradation through NF-κB-mediated threonine-286 phosphorylation.... -
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- Gene Transfer Into Human Chondrocyte Derived Cells Using A Liposome Mediated Transfection System
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Han CW, Kim WY, Kim JY, Ohm EY, Kim JM
- KMID: 2105731
- J Korean Orthop Assoc.
- 2001 Apr;36(2):127-134.
PURPOSE: To introduce the CMV promoter driven luciferase and -galactosidase marker gene into previously permeabilized human chondrial cells. MATERIALS AND METHODS: The cultured chondrocyte cells were transfected with a liposome/DNA... -
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- Long Non-Coding RNA LINC00525 Promotes the Stemness and Chemoresistance of Colorectal Cancer by Targeting miR-507/ELK3 Axis
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Wang S, Li J, Yang X
- KMID: 2465904
- Int J Stem Cells.
- 2019 Jul;12(2):347-359.
- doi: 10.15283/ijsc19041
BACKGROUND AND OBJECTIVES: This study aims to explore the effects of a long non-coding RNA, LINC00525, on colorectal cancer (CRC) and its underlying molecular mechanisms. METHODS: The qPCR, MTT, colony formation,... -
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- Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid
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Peng JF, Liu L, Guo CX, Liu SK, Chen XP, Huang LH, Xiang H, Huang ZJ, Yuan H, Yang GP
- KMID: 2380287
- Biomol Ther.
- 2015 Sep;23(5):400-406.
- doi: 10.4062/biomolther.2015.010
MicroRNAs (miRNAs) are a family of non-coding RNA that are able to adjust the expression of many proteins, including ATP-binding cassette transporter and organic cation transporter. We sought to evaluate... -
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- The increased expression of CD99 in a differentiated neuroblastoma cell line
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Choi EY, Lee IS
- KMID: 2150557
- Immune Netw.
- 2001 Apr;1(1):53-60.
- doi: 10.4110/in.2001.1.1.53
BACKGROUND: The human mic2 gene is a pseudoautosomal gene that encodes a cell surface antigen, CD99. High levels of CD99 constitute a tumor marker in Ewing s sarcoma (ES). We... -
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- Cadmium increases ferroportin-1 gene expression in J774 macrophage cells via the production of reactive oxygen species
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Park BY, Chung J
- KMID: 2313397
- Nutr Res Pract.
- 2009 Sep;3(3):192-199.
Cadmium intoxication has been associated with the dysregulation of iron homeostasis. In the present study, we investigated the effect of cadmium on the expression of ferroportin 1 (FPN1), an important... -
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- The Role of Noncoding Region in Hantaan Viral S Genome for Expression of Nucleocapsid Protein
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Yu CH, Lee YS, Lee HD, Park C, Park KY, Lee PW
- KMID: 1896561
- J Korean Soc Virol.
- 2000 Mar;30(1):39-49.
The genome of Hantaan virus, the prototype of the hantavirus genus, is composed of three segmented, single stranded negative sense RNA genome. The 5' and 3' termini of the Hantaan... -
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