- The evolving understanding of histology as an endpoint in ulcerative colitis
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Akiyama S, Miyatani Y, Rubin DT
- KMID: 2560290
- Intest Res.
- 2024 Oct;22(4):389-396.
- doi: 10.5217/ir.2023.00120
A therapeutic goal for patients with ulcerative colitis (UC) is deep remission including clinical remission and mucosal healing. Mucosal healing was previously defined by endoscopic appearance, but recent studies demonstrate... -
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- What to do when traditional rescue therapies fail in acute severe ulcerative colitis
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Li Wai Suen CFD, Choy MC, De Cruz P
- KMID: 2560291
- Intest Res.
- 2024 Oct;22(4):397-413.
- doi: 10.5217/ir.2024.00003
Acute severe ulcerative colitis (ASUC) is a medical emergency that affects approximately 25% of patients with ulcerative colitis at some point in time in their lives. Outcomes of ASUC are... -
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- Perianal fistulizing lesions of Crohn’s disease are associated with long-term behavior and its transition: a Chinese cohort study
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Zhan W, Bai X, Yang H, Qian J
- KMID: 2560298
- Intest Res.
- 2024 Oct;22(4):484-495.
- doi: 10.5217/ir.2024.00021
Background/Aims: Crohn’s disease (CD) has a progressive nature and commonly perianal involvement. The aim of this study is to assess the prevalence, surgical treatment, and outcome of perianal fistulizing CD... -
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- Complex dichotomous links of nonalcoholic fatty liver disease and inflammatory bowel disease: exploring risks, mechanisms, and management modalities
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Aggarwal K, Singh B, Goel A, Agrawal DK, Bansal S, Kanagala SG, Anamika F, Gupta A, Jain R
- KMID: 2560292
- Intest Res.
- 2024 Oct;22(4):414-427.
- doi: 10.5217/ir.2024.00001
Nonalcoholic fatty liver disease (NAFLD) has been shown to be linked to inflammatory bowel disease (IBD) due to established risk factors such as obesity, age, and type 2 diabetes in... -
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- Early change in serum leucine-rich α-2-glycoprotein predicts clinical and endoscopic response in ulcerative colitis
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Karashima R, Sagami S, Yamana Y, Maeda M, Hojo A, Miyatani Y, Nakano M, Matsuda T, Hibi T, Kobayashi T
- KMID: 2560297
- Intest Res.
- 2024 Oct;22(4):473-483.
- doi: 10.5217/ir.2023.00135
Background/Aims: Leucine-rich α-2-glycoprotein (LRG) is a new serum biomarker reflecting the disease activity of ulcerative colitis (UC), but its change during the acute phase has not been enough investigated. Methods:... -
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- Predictors of histologic remission in patients with biologic-naïve, moderate-to-severe ulcerative colitis treated with first-line biologic agents and small-molecule drugs: a single-center, retrospective cohort study
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Jo K, Kim KW, Lee HJ, Im JP, Kim JS, Koh SJ
- KMID: 2560295
- Intest Res.
- 2024 Oct;22(4):453-463.
- doi: 10.5217/ir.2024.00044
Background/Aims: The prevalence and incidence of ulcerative colitis (UC) in Korea is increasing. Each patient has a different disease course and treatment response. Recently, with the development of biologic agents,... -
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- Efficacy of serum leucine-rich alpha-2 glycoprotein in predicting findings of Crohn’s disease small bowel lesion in capsule endoscopy
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Omori T, Koroku M, Murasugi S, Ito A, Yonezawa M, Nakamura S, Tokushige K
- KMID: 2560296
- Intest Res.
- 2024 Oct;22(4):464-472.
- doi: 10.5217/ir.2023.00139
Background/Aims: Small bowel capsule endoscopy (SBCE) is an evaluation method for small bowel (SB) lesions in Crohn’s disease (CD). However, the relationship between SBCE findings and the serological biomarker leucine-rich... -
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- Defining management strategies for acute severe ulcerative colitis using predictive models: a simulation-modeling study
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Con D, De Cruz P
- KMID: 2560294
- Intest Res.
- 2024 Oct;22(4):439-452.
- doi: 10.5217/ir.2023.00175
Background/Aims: Robust management algorithms are required to reduce the residual risk of colectomy in acute severe ulcerative colitis (ASUC) refractory to standard infliximab salvage therapy. The aim of this study... -
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- Ulcerative colitis-associated neoplasms often harbor poor prognostic histologic components with low detection by biopsy
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Sakakibara R, Sugimoto S, Takabayashi K, Kiyohara H, Wakisaka Y, Kaieda Y, Kawaida M, Yoshimatsu Y, Sujino T, Hosoe N, Kato M, Shimoda M, Mikami Y, Iwao Y, Kanai T
- KMID: 2560293
- Intest Res.
- 2024 Oct;22(4):428-438.
- doi: 10.5217/ir.2024.00006
Background/Aims: Poorly differentiated adenocarcinoma, signet-ring cell carcinoma, and mucinous adenocarcinoma (por/sig/muc), which are considered to be histologic subtypes with a poor prognosis, occur more frequently with colitis-associated cancer than with... -
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