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Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models

Mizoguchi , Low D, Ezaki Y, Okada T

The specific pathogenesis underlining inflammatory bowel disease (IBD) is very complicated, and it is further more difficult to clearly explain the pathophysiology of 2 major forms of IBD, Crohn’s disease...
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Differentiation of fibrotic and inflammatory component of Crohn’s disease-associated strictures

Rimola J, Capozzi N

Patients with Crohn’s disease (CD) commonly develop bowel strictures, which may contain various degrees of inflammation and fibrosis. While predominantly inflammatory strictures may benefit from a medical anti-inflammatory treatment approach,...
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Complementary and alternative medicine in patients with inflammatory bowel disease: hype or evidence?

Cha JM

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Enteral nutrition in the biologic era: learn from yesterday, live for today, hope for tomorrow

Hisamatsu

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Prototype single-balloon enteroscopy with passive bending and high force transmission improves depth of insertion in the small intestine

Morita Y, Bamba S, Inatomi O, Takahashi , Imai T, Murata M, Ohno M, Sasaki M, Tsujikawa , Andoh A

Background/Aims: We retrospectively analyzed Crohn’s disease (CD) patients with small intestinal strictures who underwent single-balloon enteroscopy (SBE) to ascertain whether prototype SBEs with a passive bending mechanism and high force...
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Changes in prevalence and perception of complementary and alternative medicine use in Korean inflammatory bowel disease patients: results of an 8-year follow-up survey

Lee SH, Chang K, Seo KS, Cho YK, Song EM, Hwang SW, Yang DH, Ye BD, Byeon JS, Myung SJ, Yang SK, Park SH

Background/Aims: The use of complementary and alternative medicine (CAM) is a global phenomenon, including inflammatory bowel disease (IBD) patients. We aimed to assess the change in prevalence and patterns of...
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Risk Factors Associated with Impaired Ovarian Reserve in Young Women of Reproductive Age with Crohn’s Disease

Zhao Y, Chen B, He Y, Zhang S, Qiu Y, Feng R, Yang H, Zeng Z, Ben-Horin , Chen M, Mao R

Background/Aims: Crohn’s disease (CD) primarily affects young female adults of reproductive age. Few studies have been conducted on this population’s ovarian reserve status. The aim of study was to investigate...
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Clinical profile and outcomes of opioid abuse gastroenteropathy: an underdiagnosed disease entity

Mahajan R, Gupta Y, Singh A, Dhiman P, Midha V, Kakkar C, Narang V, Mehta V, Saggar K, Sood A

Background/Aims: Opioid-induced bowel dysfunction includes nausea, vomiting, constipation and abdominal distension. We describe patients presenting with gastrointestinal (GI) ulcers and ulcerated strictures secondary to opioid abuse, an entity not well...
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Exclusive enteral nutrition for induction of remission in anti-tumor necrosis factor refractory adult Crohn’s disease: the Indian experience

Sood A, Singh A, Sudhakar R, Midha V, Mahajan R, Mehta V, Gupta YK, Kaur K

Background/Aims: Exclusive enteral nutrition (EEN) is recommended for induction of remission in pediatric Crohn’s disease (CD). However, it is not currently recommended for inducing remission in adults. This report describes...
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Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice

Imai J, Yahata T, Ichikawa H, Ibrahim AA, Yazawa M, Sumiyoshi , Inagaki Y, Matsushima M, Suzuki T, Mine T, Ando K, Miyata T, Hozumi K

Background/Aims: Intestinal fibrosis is a major complication of Crohn’s disease (CD). The profibrotic protein transforming growth factor-β (TGF-β) has been considered to be critical for the induction of the fibrotic...
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Histologically confirmed upper gastrointestinal Crohn’s disease: is it rare or are we just not searching hard enough?

Saadah OI, Fallatah K, Baumann C, Elbaradie , Howladar F, Daiwali MT, Alshuaibi , Alsahafi M, Bokhary RY, Qari YA, Peyrin-Biroulet L, Mosli MH

Background/Aims: Crohn’s disease (CD) may involve the upper parts of the gastrointestinal (GI) tract including the esophagus, stomach, and duodenum. Clinical features of upper GI CD (UGICD) are not well...
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Novel biomarkers for the diagnosis and prognosis of colorectal cancer

Oh HH, Joo YE

Colorectal cancer (CRC) is among the most common malignancies and remains a major cause of cancer-related death worldwide. Despite recent advances in surgical and multimodal therapies, the overall survival of...
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