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Nervonic Acid Inhibits Replicative Senescence of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells

Kim SJ, Kwon S, Chung S, Lee EJ, Park SE, Choi SJ, Oh SY, Ryu GH, Jeon HB, Chang JW

Cellular senescence causes cell cycle arrest and promotes permanent cessation of proliferation. Since the senescence of mesenchymal stem cells (MSCs) reduces proliferation and multipotency and increases immunogenicity, aged MSCs are...
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Host-Microbe Interactions Regulate Intestinal Stem Cells and Tissue Turnover in Drosophila

Lee JH

With the activity of intestinal stem cells and continuous turnover, the gut epithelium is one of the most dynamic tissues in animals. Due to its simple yet conserved tissue structure...
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Recent Research Trends in Stem Cells Using CRISPR/Cas-Based Genome Editing Methods

Yoon DE, Lee H, Kim K

The clustered regularly interspaced short palindromic repeats (CRISPR) system, a rapidly advancing genome editing technology, allows DNA alterations into the genome of organisms. Gene editing using the CRISPR system enables...
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Unleashing the Power of Undifferentiated Induced Pluripotent Stem Cell Bioprinting: Current Progress and Future Prospects

Kim B, Kim J, Lee S

Induced pluripotent stem cell (iPSC) technology has revolutionized various fields, including stem cell research, disease modeling, and regenerative medicine. The evolution of iPSC-based models has transitioned from conventional two-dimensional systems...
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Exploring the Molecular and Developmental Dynamics of Endothelial Cell Differentiation

Shin YJ, Lee JH

The development and differentiation of endothelial cells (ECs) are fundamental processes with significant implications for both health and disease. ECs, which are found in all organs and blood vessels, play...
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Expression of Major Histocompatibility Complex during Neuronal Differentiation of Somatic Cell Nuclear Transfer-Human Embryonic Stem Cells

Lee JS, Lee JE, Yu SH, Chun T, Chang MY, Lee DR, Park CH

Human pluripotent stem cells (hPSCs) such as human embryonic stem cells (hESCs), induced pluripotent stem cells, and somatic cell nuclear transfer (SCNT)-hESCs can permanently self-renew while maintaining their capacity to...
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Lung Organoid on a Chip: A New Ensemble Model for Preclinical Studies

Kim HJ, Park S, Jeong S, Kim J, Cho YJ

The lung is a complex organ comprising a branched airway that connects the large airway and millions of terminal gas-exchange units. Traditional pulmonary biomedical research by using cell line model...
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Mimicking the Human Articular Joint with In Vitro Model of Neurons-Synoviocytes Co-Culture

Chwastek J, Kędziora M, Borczyk M, Korostyński M, Starowicz K

The development of In Vitro models is essential in modern science due to the need for experiments using human material and the reduction in the number of laboratory animals....
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Integrin α 4 Positive Subpopulation in Adipose Derived Stem Cells Effectively Reduces Infarct Size through Enhanced Engraftment into Myocardial Infarction

Yuan Z, Tan J, Wang J

The efficacy of adipose-derived stem cells (ASCs) on myocardial infarction is limited due to poor survival and engraftment. Integrin-mediated cell adhesion is a prerequisite for its survival and homing. ASCs...
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