- Regulation of Osteoclast Differentiation by Cytokine Networks
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Amarasekara DS, Yun H, Kim S, Lee N, Kim H, Rho J
- KMID: 2404891
- Immune Netw.
- 2018 Feb;18(1):e8.
- doi: 10.4110/in.2018.18.e8
Cytokines play a pivotal role in maintaining bone homeostasis. Osteoclasts (OCs), the sole bone resorbing cells, are regulated by numerous cytokines. Macrophage colony-stimulating factor and receptor activator of NF-κB ligand... -
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- Roles of IL-33 in Resistance and Tolerance to Systemic Candida albicans Infections
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Park SJ, Cho HR, Kwon B
- KMID: 2299789
- Immune Netw.
- 2016 Jun;16(3):159-164.
- doi: 10.4110/in.2016.16.3.159
IL-33 is a multifunctional cytokine that is released in response to a variety of intrinsic and extrinsic stimuli. The role of IL-33 in Candida albicans infections is just beginning to... -
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- Emerging Endotypes of Chronic Rhinosinusitis and Its Application to Precision Medicine
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Kim DW, Cho SH
- KMID: 2378192
- Allergy Asthma Immunol Res.
- 2017 Jul;9(4):299-306.
- doi: 10.4168/aair.2017.9.4.299
Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease with various underlying pathophysiologic mechanisms which translate to endotypes, in contrast to clinical phenotypes or histological subtypes. Defining endotypes can help clinicians... -
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- Immune Characterization of Bone Marrow-Derived Models of Mucosal and Connective Tissue Mast Cells
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Benedé S, Cody E, Agashe C, Berin MC
- KMID: 2409062
- Allergy Asthma Immunol Res.
- 2018 May;10(3):268-277.
- doi: 10.4168/aair.2018.10.3.268
PURPOSE: It is well appreciated that mast cells (MCs) demonstrate tissue-specific imprinting, with different biochemical and functional properties between connective tissue MCs (CTMCs) and mucosal MCs (MMCs). Although in vitro... -
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- Mucosal Immunity Related to FOXP3⺠Regulatory T Cells, Th17 Cells and Cytokines in Pediatric Inflammatory Bowel Disease
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Cho J, Kim S, Yang DH, Lee J, Park KW, Go J, Hyun CL, Jee Y, Kang KS
- KMID: 2429597
- J Korean Med Sci.
- 2018 Dec;33(52):e336.
- doi: 10.3346/jkms.2018.33.e336
BACKGROUND: We aimed to investigate mucosal immunity related to forkhead box P3 (FOXP3+) regulatory T (Treg) cells, T helper 17 (Th17) cells and cytokines in pediatric inflammatory bowel disease (IBD). METHODS:... -
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- Anti-interleukin-33 Reduces Ovalbumin-Induced Nephrotoxicity and Expression of Kidney Injury Molecule-1
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Park GH, Shinn HK, Kang JH, Na WJ, Kim YH, Park CS
- KMID: 2365742
- Int Neurourol J.
- 2016 Jun;20(2):114-121.
- doi: 10.5213/inj.1632578.289
PURPOSE: To evaluate the effect of anti-interleukin-33 (anti-IL-33) on a mouse model of ovalbumin (OVA)-induced acute kidney injury (AKI). METHODS: Twenty-four female BALB/c mice were assigned to 4 groups: group A... -
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- Herpes Zoster DNA Vaccines with IL-7 and IL-33 Molecular Adjuvants Elicit Protective T Cell Immunity
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Kim AR, Park J, Kim JH, Kwak JE, Cho Y, Lee H, Jeong M, Park SH, Shin EC
- KMID: 2424204
- Immune Netw.
- 2018 Oct;18(5):e38.
- doi: 10.4110/in.2018.18.e38
Herpes zoster (HZ), or shingles, is caused by the reactivation of latent varicella-zoster virus (VZV) from the sensory ganglia when VZV-specific T-cell immunity is decreased because of aging or immunosuppression.... -
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- IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation
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Zhang HF, Wu MX, Lin YQ, Xie SL, Huang TC, Liu PM, Nie RQ, Meng QQ, Luo NS, Chen YX, Wang JF
- KMID: 2396793
- Exp Mol Med.
- 2017 Nov;49(11):e388.
- doi: 10.1038/emm.2017.183
We evaluated the role of IL-10- in IL-33-mediated cholesterol reduction in macrophage-derived foam cells (MFCs) and the mechanism by which IL-33 upregulates IL-10. Serum IL-33 and IL-10 levels in coronary... -
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- Optimization of Cytokine Milieu to Reproduce Atopic Dermatitis-related Gene Expression in HaCaT Keratinocyte Cell Line
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Kim HJ, Baek J, Lee JR, Roh JY, Jung Y
- KMID: 2410159
- Immune Netw.
- 2018 Apr;18(2):e9.
- doi: 10.4110/in.2018.18.e9
Although atopic dermatitis (AD) is characterized by cytokine production predominantly mediated by T helper (Th) 2 cells, AD pathogenesis also involves innate immune and Th1 cells. To optimize the cytokine... -
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- Association Between Epithelial Cytokines and Clinical Phenotypes of Elderly Asthma
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Ulambayar , Lee SH, Yang EM, Ye YM, Park HS
- KMID: 2426787
- Allergy Asthma Immunol Res.
- 2019 Jan;11(1):79-89.
- doi: 10.4168/aair.2019.11.1.79
PURPOSE: Asthma in the elderly has different clinical features including more severe phenotypes with higher comorbidities. Epithelial cells are known to initiate innate/adaptive immune responses in asthmatic airways. We investigated... -
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- Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma
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Hur GY, Broide DH
- KMID: 2452752
- Allergy Asthma Immunol Res.
- 2019 Sep;11(5):604-621.
- doi: 10.4168/aair.2019.11.5.604
Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics. Airway remodeling is characterized... -
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- TRPV1 Blocking Alleviates Airway Inflammation and Remodeling in a Chronic Asthma Murine Model
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Choi JY, Lee HY, Hur J, Kim KH, Kang JY, Rhee CK, Lee SY
- KMID: 2409056
- Allergy Asthma Immunol Res.
- 2018 May;10(3):216-224.
- doi: 10.4168/aair.2018.10.3.216
PURPOSE: Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. There is emerging interest in the involvement of the transient receptor potential vanilloid 1... -
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- Citron Essential Oils Alleviate the Mediators Related to Rosacea Pathophysiology in Epidermal Keratinocytes
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Jeon HW, Na EY, Yun SJ, Lee SC, Lee JB
- KMID: 2428920
- Ann Dermatol.
- 2018 Dec;30(6):653-661.
- doi: 10.5021/ad.2018.30.6.653
BACKGROUND: Citron is well known for an abundance of antioxidative and anti-inflammatory ingredients such as vitamin C, polyphenol compounds, flavonoids, and limonoids. OBJECTIVE: In this study, we aimed to evaluate the... -
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- Relationship of Microbial Profile With Airway Immune Response in Eosinophilic or Neutrophilic Inflammation of Asthmatics
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Son JH, Kim JH, Chang HS, Park JS, Park CS
- KMID: 2471226
- Allergy Asthma Immunol Res.
- 2020 May;12(3):412-429.
- doi: 10.4168/aair.2020.12.3.412
PURPOSE: Different characteristics of airway microbiome in asthmatics may lead to differential immune responses, which in turn cause eosinophilic or neutrophilic airway inflammation. However, the relationships among these factors have... -
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- Toluene diisocyanate exposure induces airway inflammation of bronchial epithelial cells via the activation of transient receptor potential melastatin 8
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Kim JH, Jang YS, Jang SH, Jung KS, Kim SH, Ye YM, Park HS
- KMID: 2375786
- Exp Mol Med.
- 2017 Mar;49(3):e299.
- doi: 10.1038/emm.2016.161
Toluene diisocyanate (TDI) is the most important cause of occupational asthma (OA), and various pathogenic mechanisms have been suggested. Of these mechanisms, neurogenic inflammation is an important inducer of airway... -
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- Development of Aspergillus fumigatus-induced chronic atopic dermatitis mouse model
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Park A, Park H, Yu J
- KMID: 2461408
- Allergy Asthma Respir Dis.
- 2019 Jul;7(3):150-157.
- doi: 10.4168/aard.2019.7.3.150
PURPOSE: Atopic dermatitis (AD) is the most common chronic and relapsing inflammatory skin disease with skin barrier defects and altered immune responses. Chronic inflammation leads to irreversible fibrosis in the... -
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