- Role of Cyclic GMP-AMP Synthase in Sensing Human Immunodeficiency Virus
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Park YS, Kim IH, Koh YS
- KMID: 2168696
- J Bacteriol Virol.
- 2014 Jun;44(2):206-207.
- doi: 10.4167/jbv.2014.44.2.206
Cyclic guanosine monophosphate adenosine monophosphate (cGAMP) synthase (cGAS) detects human immunodeficiency virus (HIV) and produces cGAMP to induce cytokines. Reverse transcribed DNA of HIV is critical for triggering innate immune... -
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- Evaluation for the Effects of Intrathecal Sildenafil on the Formalin- and Thermal-induced Nociception of Rats
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Yoon MH, Bae HB, Shin DJ, Kim CM, Jeong ST, Kim SJ, Choi JI
- KMID: 2278011
- Korean J Pain.
- 2006 Jun;19(1):17-21.
- doi: 10.3344/kjp.2006.19.1.17
BACKGROUND: Cyclic guanosine monophosphate (cGMP) plays an important role in the modulation of nociception. Although local sildenafil produces antinociception, by increasing cGMP through the inhibition of phosphodiesterase 5, the effect... -
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- Effects and Mechanism of Action of a Tribulus terrestris Extract on Penile Erection
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Do J, Choi S, Choi J, Hyun JS
- KMID: 2430620
- Korean J Urol.
- 2013 Mar;54(3):183-188.
PURPOSE: Tribulus terrestris has been used as an aphrodisiac. However, little is known about the effects and mechanism of action of T. terrestris on penile erection. Therefore, the effect of... -
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- Penile Erection Induced by Scoparone from Artemisia capillaris through the Nitric Oxide-Cyclic Guanosine Monophosphate Signaling Pathway
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Choi BR, Kim HK, Park JK
- KMID: 2398569
- World J Mens Health.
- 2017 Dec;35(3):196-204.
- doi: 10.5534/wjmh.17023
PURPOSE: The objective of this study was to evaluate the relaxant effect of scoparone from Artemisia capillaris on rabbit penile corpus cavernosum smooth muscle (PCCSM) and to elucidate the mechanism... -
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- Effect of Zaprinast, a Phosphodiesterse Inhibitor, on Formalin-induced Nociception and Hemodynamics in the Rat Spinal Cord
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Park SK, Kim CM, Jeong ST, Kim SJ, Shin DJ, Bae HB, Choi JI, Jeong SW, Chung SS, Yoo KY, Jeong CY, Yoon MH
- KMID: 2238924
- Korean J Anesthesiol.
- 2005 Jun;48(6):651-655.
- doi: 10.4097/kjae.2005.48.6.651
BACKGROUND: Cyclic guanosine monophosphate (cGMP) is involved in antinociception and vascular relaxation. The effects of zaprinast, which increases the level of cGMP by inhibiting phosphodiesterase, in the spinal cord... -
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- Guanosine 5′-monophosphate-chelated calcium and iron feed additives maintains egg production and prevents Salmonella Gallinarum in experimentally infected layers
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Noh HJ, Kim H, Heo SJ, Cho HH, Koh HB
- KMID: 2412446
- J Vet Sci.
- 2017 Sep;18(3):291-97.
- doi: 10.4142/jvs.2017.18.3.291
We evaluated the effects of guanosine 5′-monophosphate (GMP)-chelated calcium and iron (CaFe-GMP) on health and egg quality in layers experimentally infected with Salmonella Gallinarum. In this study, a CaFe-GMP feed... -
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- Effects of cGMP on Smooth Muscle alpha-Actin Expression in Cultured Human Corporal Smooth Muscle Cells
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Kim SW, Seo SI, Paick JS
- KMID: 1960294
- J Korean Androl Soc.
- 1997 Dec;15(2):91-96.
PURPOSE: Knowledge of the mechanisms controlling intracellular signal propagation in smooth muscle is of major importance in understanding erectile function and dysfunction. We examined the effects of cGMP on alpha-actin... -
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- Nitric Oxide/cGMP-Independent Vasorelaxation Enhanced by L-Arginine
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Moon SH, Lee JE, Yoo KJ, Oh BS, Lee DJ
- KMID: 2062014
- Korean J Thorac Cardiovasc Surg.
- 1998 Feb;31(2):102-107.
It has not been clear whether L-arginine plays solely a role contributing to vascular nitric oxide (NO) synthesis. To investigate the mechanisms by which L-arginine induces vasorelaxation, effects of L-arginine... -
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- No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma
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Wang JZ, Le S, Alexanian , Boddu S, Merleev A, Marusina A, Maverakis
- KMID: 2455408
- World J Mens Health.
- 2019 Sep;37(3):313-321.
- doi: 10.5534/wjmh.180050
PURPOSE: To examine the association between phosphodiesterase type 5 (PDE5) inhibitor use and melanoma by 1) conducting a systematic review of observational studies; and 2) determining if low PDE5A gene... -
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- Water soluble tomato concentrate regulates platelet function via the mitogen-activated protein kinase pathway
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Jeong D, Irfan M, Saba E, Kim SD, Kim SH, Rhee MH
- KMID: 2368746
- Korean J Vet Res.
- 2016 Jun;56(2):67-74.
- doi: 10.14405/kjvr.2016.56.2.67
Tomato extract has been shown to exert antiplatelet activity in vitro and to change platelet function ex vivo, but with limitations. In this study, antiplatelet activity of water soluble tomato... -
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- Ginsenoside Re Enriched Fraction (GS-F3K1) from Ginseng Berries Ameliorates Ethanol-Induced Erectile Dysfunction via Nitric Oxide-cGMP Pathway
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Pyo MK, Park KH, Oh MH, Lee H, Park YS, Kim NY, Park SH, Song JH, Park JD, Jung SH, Lee BG, Won BY, Shin KY, Lee HG
- KMID: 2312921
- Nat Prod Sci.
- 2016 Mar;22(1):46-52.
- doi: 10.20307/nps.2016.22.1.46
Erectile dysfunction (ED) is a highly prevalent disorder that affects millions of men and considered to be an early symptom of atherosclerosis and a precursor of various systemic vascular disorders.... -
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- C-Type Natriuretic Peptide/Natriuretic Peptide Receptor 2 Is Involved in Cell Proliferation and Testosterone Production in Mouse Leydig Cells
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Yang L, Lei L, Zhao Q, Gong Y, Guan G, Huang S
- KMID: 2443234
- World J Mens Health.
- 2019 May;37(2):186-198.
- doi: 10.5534/wjmh.180041
PURPOSE: This study investigated the role of natriuretic peptide receptor 2 (NPR2) on cell proliferation and testosterone secretion in mouse Leydig cells. MATERIALS AND METHODS: Mouse testis of different postnatal stages... -
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- Protective Effects of Inducible HO-1 on Oxygen Toxicity in Rat Brain Endothelial Microvessel Cells
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Yoo SJ, Nakra NK, Ronnett GV, Moon C
- KMID: 2169473
- Endocrinol Metab.
- 2014 Sep;29(3):356-362.
- doi: 10.3803/EnM.2014.29.3.356
BACKGROUND: Reperfusion in ischemia is believed to generate cytotoxic oxidative stress, which mediates reperfusion injury. These stress conditions can initiate lipid peroxidation and damage to proteins, as well as promote... -
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- Effects of Sildenafil Citrate on Sodium Nitroprusside and Nitroglycerin-Induced Hypotension in Dogs
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Yoo KY, Jeong ST, Oh BH, Ha IH
- KMID: 2236766
- Korean J Anesthesiol.
- 2002 Aug;43(2):209-215.
- doi: 10.4097/kjae.2002.43.2.209
BACKGROUND: Nitrovasodilators are known to induce hypotension through activating nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway. By inhibiting the breakdown of cGMP, sildenafil citrate may augment the nitrovasodilator-induced hypotension. ... -
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- Effects of Schisandra chinensis fruit extract and gomisin A on the contractility of penile corpus cavernosum smooth muscle: a potential mechanism through the nitric oxide - cyclic guanosine monophosphate pathway
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Choi BR, Kim HK, Park JK
- KMID: 2420994
- Nutr Res Pract.
- 2018 Aug;12(4):291-297.
- doi: 10.4162/nrp.2018.12.4.291
BACKGROUND/OBJECTIVES: This study evaluated the effects and molecular mechanisms of the Schisandra chinensis fruit extract (SC) and its major compound gomisin A (GA), on the contractility of rabbit penile corpus... -
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- The Effect of Alcohol Administration on the Corpus Cavernosum
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Choi SM, Seo DH, Lee SW, Lee C, Jeh SU, Kam SC, Hwa JS, Chung KH, Hyun JS
- KMID: 2377210
- World J Mens Health.
- 2017 Apr;35(1):34-42.
- doi: 10.5534/wjmh.2017.35.1.34
PURPOSE: We studied the effects of alcohol administration on the corpus cavernosum (CC) using an animal model. MATERIALS AND METHODS: CC sections and the aortic ring of rabbits were used in... -
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- Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model
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Moon HW, Park JW, Lee KW, Jeong HC, Choi JB, Choi SW, Bae WJ, Cho HJ, Ha US, Hong SH, Geum JH, Hong SB, Kim SW
- KMID: 2377211
- World J Mens Health.
- 2017 Apr;35(1):43-50.
- doi: 10.5534/wjmh.2017.35.1.43
PURPOSE: This study investigated the effect of goji (Lycium chinense Mill.) on erectile dysfunction in old-aged rats. MATERIALS AND METHODS: Twenty-four 18-month-old male Sprague-Dawley rats (defined as old-aged rats) were used.... -
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- Antinociceptive Effect of the Intrathecal Phosphodiesterase Inhibitor, Zaprinast, in a Rat Formalin Test
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Heo BY, Kim CM, Jeong ST, Kim SJ, Choi JI, Yoon MH
- KMID: 2277970
- Korean J Pain.
- 2005 Dec;18(2):99-106.
- doi: 10.3344/kjp.2005.18.2.99
BACKGROUND: Cyclic guanosine monophosphate (cGMP) and opioid receptors are involved in the modulation of nociception. Although the opioid receptors agonists are active in pain, the effect of an phospodiesterase inhibitor... -
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- The status of blood pressure control and the effect of dialysis adequacy on blood pressure in chronic hemodialysis patients
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Koo JR, Kim MB, Park KY, Kim GH, Chun RW, Kim HJ, Chae DW, Noh JW
- KMID: 1985580
- Korean J Med.
- 1999 May;56(5):620-628.
OBJECTIVE: Volume expansion has been known to be the major factor in the development of hypertenision in chronic hemodialysis(HD) patients. But some HD patients remain hypertensive even with adequate volume control, which... -
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- Protective Effects of KH-204 in the Bladder of Androgen-Deprived Rats
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Bae WJ, Ha US, Choi JB, Kim KS, Kim SJ, Cho HJ, Hong SH, Lee JY, Wang Z, Hwang SY, Kim SW
- KMID: 2032826
- World J Mens Health.
- 2015 Aug;33(2):73-80.
- doi: 10.5534/wjmh.2015.33.2.73
PURPOSE: We investigated the protective effects of the herbal formulation KH-204 in the bladder of androgen-deprived rats. MATERIALS AND METHODS: Male rats aged eight weeks were randomly divided into four groups,... -
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