- Expression and use of Truncated Recombimnant Flagellin Protein ( FlaB ) in ELISA for Diagnosis of Leptospirosis
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Yoo CK, Paik MA, Lee HK, Park MS, Park MY
- KMID: 2099357
- J Korean Soc Microbiol.
- 2000 Oct;35(5):365-365.
No Abstract Available. -
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- Bacterial flagellin—a potent immunomodulatory agent
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Hajam IA, Dar PA, Shahnawaz , Jaume JC, Lee JH
- KMID: 2394304
- Exp Mol Med.
- 2017 Sep;49(9):e373.
- doi: 10.1038/emm.2017.172
Flagellin is a subunit protein of the flagellum, a whip-like appendage that enables bacterial motility. Traditionally, flagellin was viewed as a virulence factor that contributes to the adhesion and invasion... -
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- Cloning and DNA sequencing of flagellin gene of helicobacter pylori
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Rhee KH, Lee WK, Cho MJ, Doh YM, Baik SC, Kang KH, Park PS, Lee SY
- KMID: 1688061
- J Korean Soc Microbiol.
- 1993 Feb;28(1):23-35.
No abstract available. -
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- Enhancement of antigen-specific humoral immune responses and protein solubility through conjugation of bacterial flagellin, Vibrio vulnificus FlaB, to the N-terminus of porcine epidemic diarrhea virus surface protein antigen S0
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Oh SH, Kim Cho YS, Lee HB, Lee SM, Kim WS, Hong L, Cho CS, Choi YJ, Kang SK
- KMID: 2464086
- J Vet Sci.
- 2019 Nov;20(6):e70.
- doi: 10.4142/jvs.2019.20.e70
Porcine epidemic diarrhea (PED) is a highly contagious enteric swine disease. The large economic impact of PED on the swine industry worldwide has made the development of an effective PED... -
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- TLR4, 5, and 9 Agonists Inhibit Murine Airway Invariant Natural Killer T Cells in an IL-12-Dependent Manner
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Shim JU, Rhee JH, Koh YI
- KMID: 2167049
- Allergy Asthma Immunol Res.
- 2012 Sep;4(5):295-304.
- doi: 10.4168/aair.2012.4.5.295
PURPOSE: Invariant natural killer T (iNKT) cells may play an important role in the pathogenesis of asthma in mice and humans. Thus, an agent that modulates the function of iNKT... -
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- A Bacterial Flagellin, Vibrio vulnificus FlaB, Induces Human Dendritic Cell Maturation
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Jeong BC, Kim SY, Choi BH, Park MS, Lee JJ, Rhee JH, Lee SE
- KMID: 1574163
- J Bacteriol Virol.
- 2005 Sep;35(3):209-216.
The motile marine bacterium, Vibrio vulnificus has a total of six flagellins. Flagellin is a structural component of flagellar filament in various locomotive bacteria and is the ligand of Toll-like... -
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- Tetanus toxin fragment C fused to flagellin makes a potent mucosal vaccine
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Lee SE, Nguyen CT, Kim SY, Thi TN, Rhee JH
- KMID: 2049108
- Clin Exp Vaccine Res.
- 2015 Jan;4(1):59-67.
- doi: 10.7774/cevr.2015.4.1.59
PURPOSE: Recombinant subunit vaccines provide safe and targeted protection against microbial infections. However, the protective efficacy of recombinant subunit vaccines tends to be less potent than the whole cell vaccines,... -
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- Effect of the Heat Shock Protein 70 on the Adjuvanticity Induced by a Bacterial Flagellin of Vibrio ulnificus
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Lee SE, Bae SJ, Kim SY, Kim YR, Rhee JH
- KMID: 1574182
- J Bacteriol Virol.
- 2005 Dec;35(4):299-306.
Recently we have shown that a bacterial flagellin, Vibrio vulnifiucs FlaB (Vv-FlaB), has a strong adjuvant activity to induce protective immune response. In order to investigate the adjuvanticity of Vv-FlaB,... -
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- TLR5 Activation through NF-κB Is a Neuroprotective Mechanism of Postconditioning after Cerebral Ischemia in Mice
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Jeong J, Kim S, Lim DS, Kim SH, Doh H, Kim SD, Song YS
- KMID: 2389008
- Exp Neurobiol.
- 2017 Aug;26(4):213-226.
- doi: 10.5607/en.2017.26.4.213
Postconditioning has been shown to protect the mouse brain from ischemic injury. However, the neuroprotective mechanisms of postconditioning remain elusive. We have found that toll-like receptor 5 (TLR5) plays an... -
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- Activation of Toll-like Receptors 1, 2, 4, 5, and 7 on Human Melanocytes Modulate Pigmentation
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Jin SH, Kang HY
- KMID: 2266195
- Ann Dermatol.
- 2010 Nov;22(4):486-489.
- doi: 10.5021/ad.2010.22.4.486
Human melanocytes are not simply pigment-producing cells. It may be part of the inflammatory response, during which the pigmentary system may produce more melanin or suppress melanization. Toll-like receptors (TLRs)... -
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- Flagellin Modulates the Function of Invariant NKT Cells From Patients With Asthma via Dendritic Cells
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Shim JU, Rhee JH, Jeong JU, Koh YI
- KMID: 2391040
- Allergy Asthma Immunol Res.
- 2016 May;8(3):206-215.
- doi: 10.4168/aair.2016.8.3.206
PURPOSE: Invariant natural killer T (iNKT) cells play a critical role in the pathogenesis of asthma. We previously reported the association between circulating Th2-like iNKT cells and lung function in... -
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- Innate Immunity and Toll Like Receptors
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Kim KH
- KMID: 2140971
- Korean J Pediatr.
- 2004 Jan;47(1):6-11.
The innate immune system is essential for host defense and is responsible for early detection of pathogenic microorganisms. Whereas the structure of microbial compounds has been extensively studied, the molecular... -
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- A Fusion Protein of Derp2 Allergen and Flagellin Suppresses Experimental Allergic Asthma
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Tan W, Zheng JH, Duong TM, Koh YI, Lee SE, Rhee JH
- KMID: 2431857
- Allergy Asthma Immunol Res.
- 2019 Mar;11(2):254-266.
- doi: 10.4168/aair.2019.11.2.254
PURPOSE: The house dust mite (HDM) is one of the most important sources of indoor allergens and a significant cause of allergic rhinitis and allergic asthma. Our previous studies demonstrated... -
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- Development of inactivated Akabane and bovine ephemeral fever vaccine for cattle
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Yang DK, Kim HH, Jo HY, Choi SS, Cho IS
- KMID: 2148065
- Korean J Vet Res.
- 2015 Dec;55(4):227-232.
- doi: 10.14405/kjvr.2015.55.4.227
Akabane and bovine ephemeral fever (BEF) viruses cause vector-borne diseases. In this study, inactivated Akabane virus (AKAV)+Bovine ephemeral fever virus (BEFV) vaccines with or without recombinant vibrio flagellin (revibFlaB) protein... -
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- Intranasal immunization with a flagellin-adjuvanted peptide anticancer vaccine prevents tumor development by enhancing specific cytotoxic T lymphocyte response in a mouse model
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Nguyen CT, Hong SH, Ung TT, Verma V, Kim SY, Rhee JH, Lee SE
- KMID: 2167723
- Clin Exp Vaccine Res.
- 2013 Jul;2(2):128-134.
- doi: 10.7774/cevr.2013.2.2.128
PURPOSE: Human papillomavirus (HPV) is a significant cause of cervical cancer-related deaths worldwide. Because HPV is a sexually transmitted mucosal pathogen, enhancement of antigen-specific mucosal immune response likely serves good... -
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- Basic and Translational Understandings of Microbial Recognition by Toll-Like Receptors in the Intestine
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Rhee SH
- KMID: 2326186
- J Neurogastroenterol Motil.
- 2011 Jan;17(1):28-34.
Microbial recognition by multicellular organisms is initially accomplished by a group of pattern recognition receptors which are specialized to recognize microbe-associated molecular patterns (MAMPs) such as lipopolysaccharide, bacterial lipoprotein, CpG... -
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- Comparison of Proteome Components of Helicobacter pylori Before and After Mouse Passage
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Lee KJ, Kim BR, Cho YA, Song YG, Song JY, Lee KH, Kang HL, Baik SC, Cho MJ, Rhee KH, Seo JH, Youn HS, Lee WK
- KMID: 2168654
- J Bacteriol Virol.
- 2011 Dec;41(4):267-278.
- doi: 10.4167/jbv.2011.41.4.267
The mouse model is alleged to be a useful tool for understanding of pathophysiological roles of Helicobacter pylori in the development of gastric disorders. However, it has been observed that... -
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- Roles of Flagellar Hook-Associated Proteins in Vibrio vulnificus Motility and Virulence
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Kim SY, Hong HY, Rhee JH, Chung SS
- KMID: 2168513
- J Bacteriol Virol.
- 2008 Mar;38(1):1-10.
- doi: 10.4167/jbv.2008.38.1.1
The bacterial flagellar structure can be divided into the basal body, the hook and the filament. Three minor components called hook associated proteins (HAP1, HAP2 and HAP3) form a junction... -
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- An attenuated Salmonella vaccine secreting Lawsonia intracellularis immunogenic antigens confers dual protection against porcine proliferative enteropathy and salmonellosis in a murine model
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Park S, Won G, Lee JH
- KMID: 2448708
- J Vet Sci.
- 2019 May;20(3):e24.
- doi: 10.4142/jvs.2019.20.e24
Porcine proliferative enteropathy (PPE) caused by Lawsonia intracellularis (LI) is a global cause for substantial economic losses in the swine industry. Here, we constructed live attenuated Salmonella typhimurium (ST) mutant... -
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- Evaluation of infertility efficacy of the E. coli expressed STF2-GnRH vaccine in male cats
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Lee YJ, Jo EJ, Lee HW, Hwang BR, Kim YH, Park BJ, Cho YJ, Lee YA, Choi IS, Han JS
- KMID: 2448714
- J Vet Sci.
- 2019 May;20(3):e30.
- doi: 10.4142/jvs.2019.20.e30
Gonadotropin-releasing hormone (GnRH) is secreted from the hypothalamus and anti-GnRH antibodies are not formed under normal conditions. However, administration an excess of recombinant GnRH protein results in the formation of... -
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