- Animal models for transplant immunology: bridging bench to bedside
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Kang M, Park HK, Kim KS, Choi D
- KMID: 2563956
- Clin Transplant Res.
- 2024 Dec;38(4):354-376.
- doi: 10.4285/ctr.24.0029
The progress of transplantation has been propelled forward by animal experiments. Animal models have not only provided opportunities to understand complex immune mechanisms in transplantation but also served as a platform... -
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- Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival
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Kim GR, Nam KH, Choi JM
- KMID: 2563954
- Clin Transplant Res.
- 2024 Dec;38(4):326-340.
- doi: 10.4285/ctr.24.0057
Calcineurin inhibitors (CNIs) have been a cornerstone in solid organ transplantation for many years; however, their prolonged use is linked to significant adverse effects, most notably nephrotoxicity. Belatacept, a modified... -
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- A walk through the development of human leukocyte antigen typing: from serologic techniques to next-generation sequencing
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Choi H, Choi EJ, Kim HJ, Baek IC, Won A, Park SJ, Kim TG, Chung YJ
- KMID: 2563952
- Clin Transplant Res.
- 2024 Dec;38(4):294-308.
- doi: 10.4285/ctr.24.0055
Human leukocyte antigen (HLA) is a group of glycoproteins encoded by the major his- tocompatibility complex (MHC) that plays a pivotal role in the host's immune defense. Given that the MHC represents... -
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- Mechanisms of allorecognition and xenorecognition in transplantation
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Yun IH, Yang J
- KMID: 2563951
- Clin Transplant Res.
- 2024 Dec;38(4):273-293.
- doi: 10.4285/ctr.24.0056
Foreign antigen recognition is the ability of immune cells to distinguish self from nonself, which is crucial for immune responses in both invertebrates and vertebrates. In vertebrates, T cells play... -
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- Beyond the icebox: modern strategies in organ preservation for transplantation
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Yemaneberhan KH, Kang M, Jang JH, Kim JH, Kim KS, Park HB, Choi D
- KMID: 2563957
- Clin Transplant Res.
- 2024 Dec;38(4):377-403.
- doi: 10.4285/ctr.24.0039
Organ transplantation, a critical treatment for end-stage organ failure, has witnessed significant advancements due to the integration of improved surgical techniques, immunosuppressive therapies, and donor-recipient matching. This review explores the... -
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- Targeting T helper 17 cells: emerging strategies for overcoming transplant rejection
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Lee YJ, Cho ML
- KMID: 2563953
- Clin Transplant Res.
- 2024 Dec;38(4):309-325.
- doi: 10.4285/ctr.24.0058
Solid organ transplantation has significantly improved the survival rate of patients with terminal organ failure. However, its success is often compromised by allograft rejection, a process in which T helper... -
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- Advancing immunosuppression in liver transplantation: the role of regulatory T cells in immune modulation and graft tolerance
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Han JW, Park SH
- KMID: 2563950
- Clin Transplant Res.
- 2024 Dec;38(4):257-272.
- doi: 10.4285/ctr.24.0059
Prolonged immunosuppressive therapy in liver transplantation (LT) is associated with significant adverse effects, such as nephrotoxicity, metabolic complications, and heightened risk of infection or malignancy. Regulatory T cells (Tregs) represent... -
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- SARS-CoV-2 vaccine-elicited immune responses in solid organ transplant recipients
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Seo E, Shin EC, Jung MK
- KMID: 2563949
- Clin Transplant Res.
- 2024 Dec;38(4):247-256.
- doi: 10.4285/ctr.24.0062
Solid organ transplant recipients (SOTRs) are considered a high-risk group for coronavirus disease 2019 (COVID-19). The adaptive immune responses generated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination include... -
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- Contribution of long-lived plasma cells to antibody-mediated allograft rejection
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Jang E, Youn J
- KMID: 2563955
- Clin Transplant Res.
- 2024 Dec;38(4):341-353.
- doi: 10.4285/ctr.24.0047
Persistent alloantigens derived from allograft tissues can be recognized by the host’s alloreactive immune system. This process enables cognate B cells to differentiate into plasma cells, which secrete donor-specific antibodies... -
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