- Ceramides: Nutrient Signals that Drive Hepatosteatosis
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Summers SA
- KMID: 2470800
- J Lipid Atheroscler.
- 2020 Jan;9(1):50-65.
- doi: 10.12997/jla.2020.9.1.50
Ceramides are minor components of the hepatic lipidome that have major effects on liver function. These products of lipid and protein metabolism accumulate when the energy needs of the hepatocyte... -
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- Stratum Corneum Ceramides and Free Amino Acids in the Lesion of Scaly Hand Eczema
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Lee MA, Hahm JH
- KMID: 2303244
- Korean J Dermatol.
- 2000 Jul;38(7):893-901.
BACKGROUND: Lipids of horny layer forming multiple lamellar structure in the intercellular space acts as a skin barrier having a primary protective function and keeps softness and flexibility of the... -
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- Ceramides and Cell Signaling Molecules in Psoriatic Epidermis: Reduced Levels of Ceramides, PKC-alpha, and JNK
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Lew BL, Cho Y, Kim J, Sim WY, Kim NI
- KMID: 2157790
- J Korean Med Sci.
- 2006 Feb;21(1):95-99.
- doi: 10.3346/jkms.2006.21.1.95
Ceramides are the main lipids in the stratum corneum and are generated during cellular stress and apoptosis by de novo synthesis or by the action of sphingomyelinase. In addition, they... -
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- The Effect of Gromwell (Lithospermum erythrorhizon) Extract on the Stratum Corneum Hydration and Ceramides Content in Atopic Dermatitis Patients
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Cho HR, Cho Y, Kim J, Seo DB, Kim SH, Lee SJ, Kim NI
- KMID: 2172085
- Ann Dermatol.
- 2008 Jun;20(2):56-66.
- doi: 10.5021/ad.2008.20.2.56
BACKGROUND: A disruption of the balance between the water content of the stratum corneum (SC) and skin surface lipids may lead to the clinical manifestation of dryness of skin in... -
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- Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth
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Oh JH, Jeong KH, Kim JE, Kang H
- KMID: 2439062
- Ann Dermatol.
- 2019 Apr;31(2):164-174.
- doi: 10.5021/ad.2019.31.2.164
BACKGROUND: The ceramide is known to play an important role in the formation of intracellular lipids, and play a crucial role as a barrier for skin and hair cuticle. Recent... -
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- Quantitative Analysis of Solvent Extracted Skin Surface Lipid in Human Skin ( - hexane, hexane/ methanol, ethanol - )
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Kang HJ
- KMID: 2303530
- Korean J Dermatol.
- 1996 Dec;34(6):973-979.
BACKGROUND: The cornposition and biosynthesis of lipids in human skin have long been of considerable interest. Several authors have reviewed the sampling procedures for collecting skin surface lipid. Composition of... -
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- Induction of a Hardening Phenomenon and Quantitative Changes of Ceramides in Stratum Corneum
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Park SY, Kim JH, Cho SI, Kim KI, Cho HJ, Park CW, Lee CH, Kim HO
- KMID: 2265695
- Ann Dermatol.
- 2014 Feb;26(1):35-42.
- doi: 10.5021/ad.2014.26.1.35
BACKGROUND: Hardening phenomenon of human skin after repeated exposure to the irritants is well-known, but the precise mechanism remains elusive. OBJECTIVE: To modify the previous experimental model of hardening phenomenon by... -
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- Dietary effect of red ginseng extracts mixed with torilis fructus and corni fructus on the epidermal levels of ceramides and ceramide related enzyme proteins in uv-induced hairless mice
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Lee YJ, Oh IG, Cho Y
- KMID: 2268685
- Korean J Nutr.
- 2012 Jun;45(3):211-217.
- doi: 10.4163/kjn.2012.45.3.211
UV-irradiation is a major factor of photo-aged skin, by which pigmentation, wrinkles and laxity are increased. In addition, the epidermal barrier is disrupted, ultimately causing dryness in photo-aged skin. As... -
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- Epidermal Lipid Homeostasis
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Lee SH, Chung HS, Lew W
- KMID: 2383065
- Ann Dermatol.
- 1995 Apr;7(2):99-111.
- doi: 10.5021/ad.1995.7.2.99
Stratum corneum lipids, which are enriched in sphingolipids, free fatty acids, and cholesterol, are required for epidermal barrier function. When the epidermal permeability barrier is perturbed, the transepidermal water loss... -
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- An Inverse Relationship Between Ceramide Synthesis and Clinical Severity in Patients with Psoriasis
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Cho Y, Lew BL, Seong K, Kim NI
- KMID: 1778569
- J Korean Med Sci.
- 2004 Dec;19(6):859-863.
- doi: 10.3346/jkms.2004.19.6.859
Ceramides play major roles in maintaining the epidermal barrier. It has been sus-pected that the depletion of ceramides, associated with disrupted barrier function in the epidermis, leads to the clinical... -
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- Sphingolipid Mediators of Myocardial Pathology
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Kovilakath A, Cowart LA
- KMID: 2470799
- J Lipid Atheroscler.
- 2020 Jan;9(1):23-49.
- doi: 10.12997/jla.2020.9.1.23
Cardiomyopathy is the leading cause of mortality worldwide. While the causes of cardiomyopathy continue to be elucidated, current evidence suggests that aberrant bioactive lipid signaling plays a crucial role as... -
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- A Study on Altered Expression of Serine Palmitoyltransferase and Ceramidase in Psoriatic Skin Lesion
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Hong KK, Cho HR, Ju WC, Cho Y, Kim NI
- KMID: 1713294
- J Korean Med Sci.
- 2007 Oct;22(5):862-867.
- doi: 10.3346/jkms.2007.22.5.862
Ceramides are the main lipid component maintaining the lamellae structure of stratum corneum, as well as lipid second messengers for the regulation of cellular proliferation and/or apoptosis. In our previous... -
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- The Apoptosis induced by Ceramide and Phytoceramide in the Lens Epithelial Cell
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Chae JB, Kim TI, Tchah H
- KMID: 2337121
- J Korean Ophthalmol Soc.
- 2003 Nov;44(11):2627-2636.
PURPOSE: The purpose of this study was to determine if ceramide, which is known as secondary messenger of programmed cell death (apoptosis), can cause apoptosis in lens epithelial cell (LEC)... -
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- Definition, Pathogenesis, and Natural Progress of Non-alcoholic Fatty Liver Disease
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Jeon JH, Park KG
- KMID: 2173896
- J Korean Diabetes.
- 2014 Jun;15(2):65-70.
- doi: 10.4093/jkd.2014.15.2.65
Non-alcoholic fatty liver disease (NAFLD) is emerging as a world-wide health problem and is currently recognized as a hepatic manifestation of metabolic syndrome. It is an umbrella term to describe... -
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- Atopic dermatitis and skin barrier dysfunction
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Kim H, Shin JU, Lee KH
- KMID: 2263055
- Allergy Asthma Respir Dis.
- 2013 Mar;1(1):20-28.
- doi: 10.4168/aard.2013.1.1.20
Atopic dermatitis is a chronic relapsing eczematous dermatosis, which usually starts in childhood, and various causes are intricately associated with the development of the disease. Recently, various abnormalities in barrier... -
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- The Clinical Efficacy of a Multi-Lamellar Emulsion Containing Pseudoceramide in Childhood Atopic Dermatitis: An Open Crossover Study
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Lee EJ, Suhr KB, Lee JH, Park JK, Jin CY, Youm JK, Park BD
- KMID: 2171840
- Ann Dermatol.
- 2003 Dec;15(4):133-138.
- doi: 10.5021/ad.2003.15.4.133
BACKGROUND: The abnormal barrier function in atopic dermatitis(AD) is caused by a reduction in the amounts of ceramides in the intercellular lipids in the stratum corneum(SC). Replenishing the SC via... -
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- Dietary effect of silk protein on epidermal levels of free sphingoid bases and phosphate metabolites in NC/Nga mice
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Kim Y, Song EH, Shin K, Lee Y, Cho Y
- KMID: 2268660
- Korean J Nutr.
- 2012 Apr;45(2):113-120.
- doi: 10.4163/kjn.2012.45.2.113
In our previous studies, dietary supplements of silk protein, sericin, and fibroin, were beneficial for improving epidermal levels of ceramides, which are the major lipids for maintaining the epidermal barrier.... -
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- Growth Inhibitory Effects and Mechanisms of Ceramides in Renal Cell Carcinoma Cells
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Kim CS, Hong JH, Park HK, Hong JH, Hwang O, Park T
- KMID: 2289958
- Korean J Urol.
- 1999 Mar;40(3):285-291.
PURPOSE: Because metastatic renal cell carcinoma responds to various forms of therapy with low remission rates, safe therapeutic agents is urgently needed. Ceramide is a potent and specific suppressor of... -
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- The Apoptosis Induced by Ceramide in the Endothelial Cell
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Lee SY, Kim TI, Tchag H
- KMID: 2206691
- J Korean Ophthalmol Soc.
- 2003 Sep;44(9):2128-2136.
PURPOSE: To evaluate the effect of variable ceramides on the apoptosis of corneal endothelial cell and then, if ceramide induce the apoptosis in endothelial cells, via which pathway apoptosis occur.... -
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- Altered Levels of Sphingosine and Sphinganine in Psoriatic Epidermis
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Moon SH, Kim JY, Song EH, Shin MK, Cho YH, Kim NI
- KMID: 2265872
- Ann Dermatol.
- 2013 Aug;25(3):321-326.
- doi: 10.5021/ad.2013.25.3.321
BACKGROUND: Ceramides are the main lipid component of the stratum corneum and are a structurally heterogeneous and complex group of sphingolipids of which sphingoid bases are the basic structural constituents.... -
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