- The Expression of ERCC1, RRM1, and BRCA1 in Breast Cancer According to the Immunohistochemical Phenotypes
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Kim D, Jung W, Koo JS
- KMID: 2157871
- J Korean Med Sci.
- 2011 Mar;26(3):352-359.
- doi: 10.3346/jkms.2011.26.3.352
We studied the expression of BRCA1, ERCC1, and RRM1 which play an important role in DNA repair systems in breast cancer. Immunohistochemical staining for EGFR, BRCA1, ERCC1, and RRM1 were... -
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- Vitamin D receptor gene polymorphisms in breast cancer
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Buyru N, Tezol A, Yosunkaya-Fenerci E, Dalay N
- KMID: 1119338
- Exp Mol Med.
- 2003 Dec;35(6):550-555.
Breast cancer is the leading cause of cancer death among women around the world and its incidence is annually increasing. The vitamin D receptor (VDR) gene is a member of... -
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- Prognostic Significance of HER2 Gene Amplification According to Stage of Breast Cancer
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Kim YS, Won YS, Park KS, Song BJ, Kim JS, Oh SJ, Jeon HM, Jung SS, Park WC
- KMID: 1786878
- J Korean Med Sci.
- 2008 Jun;23(3):414-420.
- doi: 10.3346/jkms.2008.23.3.414
It is well known that the amplification of the HER2 gene is closely associated with poor prognosis of breast cancer. However, there is controversy about the clinical significance of HER2... -
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- Activation of KRAS promotes the mesenchymal features of basal-type breast cancer
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Kim RK, Suh Y, Yoo KC, Cui YH, Kim H, Kim MJ, Kim IG, Lee SJ
- KMID: 2155402
- Exp Mol Med.
- 2015 Jan;47(1):e137.
- doi: 10.1038/emm.2014.99
Basal-type breast cancers are among the most aggressive and deadly breast cancer subtypes, displaying a high metastatic ability associated with mesenchymal features. However, the molecular mechanisms underlying the maintenance of... -
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- EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations
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Zhou W, Jiang Z, Li X, Xu F, Liu Y, Wen P, Kong L, Hou M, Yu J
- KMID: 1794413
- J Korean Med Sci.
- 2009 Feb;24(1):97-103.
- doi: 10.3346/jkms.2009.24.1.97
Epithelial membrane protein 3 (EMP3) is a trans-membrane signaling molecule with important roles in the regulation of apoptosis, differentiation and invasion of cancer cells, but the detailed is largely still... -
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- Evaluation of Intratumoral HER-2 Heterogeneity by Fluorescence In Situ Hybridization in Invasive Breast Cancer: A Single Institution Study
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Lee S, Jung W, Hong SW, Koo JS
- KMID: 1777837
- J Korean Med Sci.
- 2011 Aug;26(8):1001-1006.
- doi: 10.3346/jkms.2011.26.8.1001
This study aimed to determine the incidence and characteristics of HER-2 gene heterogeneity in invasive breast cancer in a single institution. Included were 971 cases of primary invasive breast cancer... -
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- Overexpressions of Cyclin B1, cdc2, p16 and p53 in Human Breast Cancer: The Clinicopathologic Correlations and Prognostic Implications
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Chae SW, Sohn JH, Kim DH, Choi YJ, Park YL, Kim K, Cho YH, Pyo JS, Kim JH
- KMID: 1777016
- Yonsei Med J.
- 2011 May;52(3):445-453.
- doi: 10.3349/ymj.2011.52.3.445
PURPOSE: The molecular mechanisms that are responsible for the initiation and progression of breast cancers are largely unknown. This study was to analyze the cyclin B1, cdc2, p53 and p16... -
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- Downregulation of the RUNX3 Gene by Promoter Hypermethylation and Hemizygous Deletion in Breast Cancer
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Hwang KT, Han W, Bae JY, Hwang SE, Shin HJ, Lee JE, Kim SW, Min HJ, Noh DY
- KMID: 1785785
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S24-S31.
- doi: 10.3346/jkms.2007.22.S.S24
The RUNX3 gene is regarded as a tumor suppressor gene in many human solid tumors, and its inactivation is believed to be related with solid tumor carcinogenesis. As little information... -
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- Obesity and genetic polymorphism of ERCC2 and ERCC4 as modifiers of risk of breast cancer
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Lee SA, Lee KM, Park WY, Kim B, Nam J, Yoo KY, Noh DY, Ahn SH, Hirvonen A, Kang D
- KMID: 755746
- Exp Mol Med.
- 2005 Apr;37(2):86-90.
To evaluate the relationship of genetic polymorphisms of ERCC2 and ERCC4 genes, both involved in nucleotide excision repair (NER), and the risk of breast cancer, a hospital-based case-control study was... -
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- The Role of Microsatellite Instability at Chromosome 11p15.5 in the Progression of Breast Ductal Carcinoma
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Kim DJ, Park JY, Lee MH, Sohn YK
- KMID: 1733512
- J Korean Med Sci.
- 2004 Oct;19(5):698-703.
- doi: 10.3346/jkms.2004.19.5.698
The study of microsatellite instability (MSI) has provided the evidence to support asequential, progressive pathway for the development of cancer. In this study, we analyzed the role of MSI at... -
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- Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast ancer risk in Korean women
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Shin A, Kang D, Choi JY, Lee KM, Park SK, Noh DY, Ahn SH, Yoo KY
- KMID: 1047087
- Exp Mol Med.
- 2007 Jun;39(3):361-366.
Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma. We evaluated the associations between two... -
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- Ovarian cancer screening in menopausal females with a family history of breast or ovarian cancer
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Lai T, Kessel B, Ahn HJ, Terada KY
- KMID: 2374243
- J Gynecol Oncol.
- 2016 Jul;27(4):e41.
- doi: 10.3802/jgo.2016.27.e41
OBJECTIVE: To determine whether annual screening reduces ovarian cancer mortality in women with a family history of breast or ovarian cancer. METHODS: Data was obtained from the Prostate, Lung, Colorectal, and... -
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- Neuronal Apoptosis Inhibitory Protein is Overexpressed in Patients with Unfavorable Prognostic Factors in Breast Cancer
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Choi J, Hwang YK, Choi YJ, Yoo KE, Kim JH, Nam SJ, Yang JH, Lee SJ, Yoo KH, Sung KW, Koo HH, Im YH
- KMID: 1785784
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S17-S23.
- doi: 10.3346/jkms.2007.22.S.S17
Neuronal apoptosis inhibitory protein (NAIP) is a recently identified inhibitor of apoptosis protein. However, the clinical relevance of NAIP expression is not completely understood. In an attempt to determine the... -
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- Comparison of Methylation Profiling in Cancerous and Their Corresponding Normal Tissues from Korean Patients with Breast Cancer
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Jung EJ, Kim IS, Lee EY, Kang JE, Lee SM, Kim DC, Kim JY, Park ST
- KMID: 1711317
- Ann Lab Med.
- 2013 Nov;33(6):431-440.
- doi: 10.3343/alm.2013.33.6.431
BACKGROUND: Aberrant DNA hypermethylation plays a pivotal role in carcinogenesis and disease progression; therefore, accurate measurement of differential gene methylation patterns among many genes is likely to reveal biomarkers for... -
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- Transcriptional targeting of gene expression in breast cancer by the promoters of protein regulator of cytokinesis 1 and ribonuclease reductase 2
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Yun HJ, Cho YH, Moon Y, Park YW, Yoon HK, Kim YJ, Cho SH, Lee YI, Kang BS, Kim WJ, Park K, Seo W
- KMID: 756337
- Exp Mol Med.
- 2008 Jun;40(3):345-353.
- doi: 10.3858/emm.2008.40.3.345
For cancer gene therapy, cancer-specific over-expression of a therapeutic gene is required to reduce side effects derived from expression of the gene in normal cells. To develop such an expression... -
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- HER-2/neu Oncogene Amplification by Chromogenic in situ Hybridization in 130 Breast Cancers Using Tissue Microarray and Clinical Follow-up Studies
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Chang E, Lee A, Lee E, Lee H, Shin O, Oh S, Kang C
- KMID: 1786817
- J Korean Med Sci.
- 2004 Jun;19(3):390-396.
- doi: 10.3346/jkms.2004.19.3.390
Determining of HER-2/neu oncogene amplification has become clinically important for managing breast cancer. Fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) are currently regarded as the standard methods. Chromogenic in... -
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- Gene Expression Profiling of Breast Cancers with Emphasis of beta-Catenin Regulation
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Roh MS, Hong SH, Jeong JS, Kwon HC, Kim MC, Cho SH, Yoon JH, Hwang TH
- KMID: 1733489
- J Korean Med Sci.
- 2004 Apr;19(2):275-282.
- doi: 10.3346/jkms.2004.19.2.275
To gain molecular understanding of carcinogenesis of breast cancer, gene expression profiles were analyzed using cDNA microarray representing 4,600 cDNAs in 10 breast cancer samples and the adjacent noncancerous breast... -
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- Pathologic findings at risk-reducing salpingo-oophorectomy (RRSO) in germline BRCA mutation carriers with breast cancer: significance of bilateral RRSO at the optimal age in germline BRCA mutation carriers
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Lee YJ, Lee SW, Kim KR, Jung KH, Lee JW, Kim YM
- KMID: 2413850
- J Gynecol Oncol.
- 2017 Jan;28(1):e3.
- doi: 10.3802/jgo.2017.28.e3
OBJECTIVE: Most BRCA1/2 carriers do not undergo risk-reducing salpingo-oophorectomy (RRSO) by the recommended age. This study aimed to find the incidence of precursor lesions and cancer after RRSO. METHODS: We retrospectively... -
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- Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells
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Joung YH, Lim EJ, Lee MY, Park JH, Ye SK, Park EU, Kim SY, Zhang Z, Lee KJ, Park DK, Park T, Moon WK, Yang YM
- KMID: 1093470
- Exp Mol Med.
- 2005 Aug;37(4):353-364.
Hypoxia, a common consequence of solid tumor growth in breast cancer or other cancers, serves to propagate a cascade of molecular pathways which include angiogenesis, glycolysis, and various cellcycle control... -
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- Integrated analysis of copy number alteration and RNA expression profiles of cancer using a high-resolution whole-genome oligonucleotide array
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Jung SH, Shin SH, Yim SH, Choi HS, Lee SH, Chung YJ
- KMID: 1058020
- Exp Mol Med.
- 2009 Jul;41(7):462-470.
- doi: 10.3858/emm.2009.41.7.051
Recently, microarray-based comparative genomic hybridization (array-CGH) has emerged as a very efficient technology with higher resolution for the genome-wide identification of copy number alterations (CNA). Although CNAs are thought to... -
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