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A Case of Cutaneous Plasmacytoma Treated with Bortezomib and Radiotherapy

Jeong KH, Yoon HJ, Lee MH

  • KMID: 2247932
  • Korean J Dermatol.
  • 2009 Apr;47(4):483-486.
Multiple myeloma is a hematologic malignancy characterized by the proliferation of monoclonal plasma cells that produce monoclonal immunoglobulins. Cutaneous involvement is very uncommon in patients with multiple myeloma. It usually...
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Diagnosis and therapy of multiple myeloma

Palumbo A, Cerrato C

Many advances in the treatment of multiple myeloma have been made due to the use of transplantation and the introduction of novel agents including thalidomide, lenalidomide, and bortezomib. The first...
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Bortezomib Induced Tumor Lysis Syndrome in Multiple Myeloma

Yu S, Ryu SW, Kim KH, Kim SH, Lee NS, Park SK, Won JH

  • KMID: 2317696
  • Soonchunhyang Med Sci.
  • 2013 Jun;19(1):31-33.
The tumor lysis syndrome (TLS) commonly occurs in the lymphoproliferative disorder, either spontaneously or in response to therapy. TLS is uncommon in multiple myeloma. However, with the use of bortezomib...
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A Case of Tinea Corporis Mimicking Erythema Annulare Centrifugum in a Patient Treated with Chemotherapy Due to Multiple Myeloma

Kim EJ, Kim HS, Kim HO, Park YM

  • KMID: 2243099
  • Korean J Med Mycol.
  • 2009 Sep;14(3):150-154.
Tinea corporis usually presents as an erythematous annular plaque with a scaly, concentrically expanding border. However, it is often difficult to diagnose when the initial manifestation is atypical, especially in...
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A Case of Drug-Induced Hepatitis due to Bortezomib in Multiple Myeloma

Kim Y, Kim KY, Lee SH, Chung YY, Yahng SA, Lee SE, Park G, Min CK

We report on a case of severe hepatotoxicity in a 52-year-old male with multiple myeloma (MM) who had received bortezomib therapy. At patient presentation, liver enzymes were normal, but started...
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A Case of Multiple Solitary Plasmacytoma Recurring in Multiple Visceral Organs

Song IC, Baek SW, Lee KS, Yun GW, Yang YJ, Kim JM, Jo DY

  • KMID: 2258964
  • Korean J Med.
  • 2011 May;80(5):609-614.
Multiple solitary plasmacytoma is a very rare disease entity, which occurs in up to 5% of patients with solitary plasmacytomas. We report an atypical case of multiple solitary plasmacytoma that...
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A Case of Primary Systemic Amyloidosis Confirmed by Various Diagnostic Tools and Repeated Skin Biopsies

Ko BJ, Lee GM, Choi IH, Park YL, Lee SY, Whang KU

  • KMID: 2246593
  • Korean J Dermatol.
  • 2013 Sep;51(9):713-717.
Amyloidosis is a group of disorders resulting from the extracellular deposition of amyloid fibrils in tissues and organs. Primary systemic amyloidosis may be myeloma-associated or idiopathic. It involves the kidney,...
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A Case of Successful Allogeneic Stem Cell Transplantation for Chemotherapy-refractory Hepatosplenic gamma delta-T Cell Lymphoma

Kim SB, Jeong SH, Park JH, Kim HS, Kim BK, Lee HS

Hepatosplenic T-cell lymphoma is a rare histologic type of peripheral T-cell lymphoma, which is characterized clinically by predominant involvement of the liver and spleen, with little or no adenopathy, and...
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Maintaining the Constant Exposure Condition for an Acute Caenorhabditis elegans Mortality Test Using Passive Dosing

Kwon HC, Roh JY, Lim D, Choi J, Kwon JH

  • KMID: 2380165
  • Environ Health Toxicol.
  • 2011 ;26(1):e2011015.
OBJECTIVES: Maintaining the constant exposure to hydrophobic organic compouds in acute toxicity tests is one of the most difficult issues in the evaluation of their toxicity and corresponding risks. Passive...
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Bortezomib Therapy Followed by Autologous Stem Cell Transplantation in POEMS Syndrome

Kang SH, Lee JY, Chun SH, Park HW, Min CK, Kim CC, Kim M, Kim Y

BACKGROUND: The acronym POEMS refers to polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes. Increased levels of cytokines, including vascular endothelial growth factor (VEGF), appear to play a pathogenic role....
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Proteasome-Inhibitor-Based Primary Therapy for Antibody-Mediated Rejection in a Renal Transplant Recipient

Park SJ, Yu H, Kang SH, Baek SD, Baek CH, Jeong JH, Park SK

  • KMID: 2264162
  • Korean J Med.
  • 2011 Dec;81(6):780-785.
Donor-specific anti-human leukocyte antigen antibodies (DSA) following kidney transplantation predict the evolution of humoral rejection and reduced graft survival. Rapid, complete elimination of DSA during antibody-mediated rejection (AMR) is rarely...
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A Case of Bortezomib-Associated Cutaneous Lymphocytic Vasculitis

Lee KJ, Kim JE, Park HJ, Lee JY, Cho BK

  • KMID: 2247734
  • Korean J Dermatol.
  • 2009 Dec;47(12):1392-1396.
Bortezomib (Velcade(R)) is a newly developed chemotherapeutic agent that is mainly used for the treatment of multiple myeloma. It is a selective and reversible inhibitor of proteasome, which is a...
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Bortezomib and melphalan as a conditioning regimen for autologous stem cell transplantation in multiple myeloma

Lee SR, Kim SJ, Park Y, Sung HJ, Choi CW, Kim BS

BACKGROUND: High-dose melphalan (200 mg/m2) with autologous stem cell transplantation (ASCT) is the standard treatment for young patients with multiple myeloma (MM). However, the response rates after ASCT are often...
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Poor prognostic significance of Mycobacterium tuberculosis infection during bortezomib-containing chemotherapy in patients with multiple myeloma

Ahn JS, Rew SY, Yang DH, Jung SH, Kang SJ, Kim MY, Lee SS, Kim YK, Kim HJ, Lee JJ

BACKGROUND: Bortezomib administration leads to a transient decrease in CD4+ T cells, increasing the susceptibility to opportunistic infections. The activation and proliferation of CD4+ T cells are particularly important in...
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Escherichia coli pap Genes as well as Adenovirus Type 11 and Type 21, and BK Virus were Involved with Severe Urinary Tract Infection in Infants

Park HK, Woo SY, Lee EO, Cha JE, Lee KE, Park H, Lee SJ

In infants, urinary tract infections (UTIs) are quite common and primarily caused by bacterial pathogens. However, little research has been conducted regarding the relationship between uropathogenic bacteria, virulent genes, and...
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Use of Bortezomib as Anti-Humoral Therapy in Kidney Transplantation

Yang KS, Jeon H, Park Y, Jo IH, Kim JI, Moon IS, Choi BS, Park CW, Yang CW, Kim YS, Chung BH

This study aimed to investigate the effect of bortezomib in the desensitization and treatment of acute antibody mediated rejection (AAMR) in kidney transplantation. Nine patients who received bortezomib therapy for...
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Detection of Virulence Genes of Staphyloccus aureus and Staphylococcus epidermidis Isolated from Suprapubic Urine from Infants with Fever

Park HK, Woo SY, Jung YJ, Lee EO, Cha JE, Park HS, Lee SJ

While methicillin-resistant Staphylococcus aureus (MRSA) isolated from urinary tract infection (UTI) has recently increased in elderly adult urology patients, it has been only rarely reported in infants. Therefore, in this...
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Combination treatment with 2-methoxyestradiol overcomes bortezomib resistance of multiple myeloma cells

Song IS, Jeong YJ, Jeong SH, Heo HJ, Kim HK, Lee SR, Ko TH, Youm JB, Kim N, Ko KS, Rhee BD, Han J

  • KMID: 2154269
  • Exp Mol Med.
  • 2013 Oct;45(10):e50.
Bortezomib is a proteasome inhibitor used for the treatment of relapsed/refractory multiple myeloma (MM). However, intrinsic and acquired resistance to bortezomib has already been observed in MM patients. In a...
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The impact of novel therapeutic agents before and after frontline autologous stem cell transplantation in patients with multiple myeloma

Min CK, Lee SE, Yahng SA, Cho BS, Eom KS, Kim YJ, Kim HJ, Lee S, Cho SG, Kim DW, Lee JW, Min WS, Park CW

BACKGROUND: Novel agents (NAs) such as thalidomide and bortezomib have been administered in combination with autologous stem-cell transplantation (ASCT) to effectively treat multiple myeloma (MM). However, whether NAs perform better...
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The risk factors for herpes zoster in bortezomib treatment in patients with multiple myeloma

Yi YS, Chung JS, Song MK, Shin HJ, Seol YM, Choi YJ, Cho GJ, Lee GW, Moon JH, Hwang IH, Ahn KH, Lee HS, Shin KH, Hwang JM

BACKGROUND: Bortezomib has significant activity in treating multiple myeloma (MM). The risk of herpes zoster (HZ) has been reported to increase significantly with bortezomib treatment, but the predisposing factors for...
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