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Growth Factor- and Phorbol Ester-induced Production and Gene Expression of MUC5AC Mucin in Human Airway Epithelial NCI-H292 Cells Were Inhibited by Afzelin and Natural Products Derived from Houttuynia Cordata

Kim YJ, Lee HJ, Lee CJ

In the present study, we investigated whether quercitrin, quercetin and afzelin derived from Houttuynia cordata affect the production and gene expression of MUC5AC mucin from airway epithelial cells. Confluent NCI-H292...
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Natural Products as Sources of Novel Drug Candidates for the Pharmacological Management of Osteoarthritis: A Narrative Review

Kang YH, Lee HJ, Lee CJ, Park JS

Osteoarthritis is a chronic degenerative articular disorder. Formation of bone spurs, synovial inflammation, loss of cartilage, and underlying bone restructuring have been reported to be the main pathologic characteristics of...
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Regulation of Neural Stem Cell Fate by Natural Products

Kim HJ

Neural stem cells (NSCs) can proliferate and differentiate into multiple cell types that constitute the nervous system. NSCs can be derived from developing fetuses, embryonic stem cells, or induced pluripotent...
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Sleep-Aids Derived from Natural Products

Hu Z, Oh S, Ha TW, Hong JT, Oh KW

Although drugs such as barbiturates and benzodiazepines are often used for the treatment of insomnia, they are associated with various side effects such as habituations, tolerance and addiction. Alternatively, natural...
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Comparison of Treatment Guidelines for Ulcerative Colitis: Role of Biologics

Bae JH, Yang DH

Ulcerative colitis (UC) is a chronic inflammatory condition of the colon, characterized by diffuse mucosal inflammation with bloody diarrhea. The therapeutic goals in UC have evolved from symptomatic relief to...
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Vaccination for Patients with Rheumatic Diseases in the Era of Biologics

Han SH

A large proportion of patients with rheumatic disease have an immunocompromised status resulting from disease pathogenesis itself and/or several immunosuppressive drugs including biologics. These conditions are closely related to a...
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Comparing Effectiveness Rituximab (Mabthera®) to Other Second-line Biologics for Rheumatoid Arthritis Treatment in Patients Refractory to or Intolerant of First-line Anti-tumor Necrosis Factor Agent: An Observational Study

Park YW, Kim KJ, Yang HI, Yoon BY, Kim SH, Kim SH, Kim J, Oh JS, Kim WU, Lee YA, Choe JY, Park MC, Lee SH

OBJECTIVE: Failure of first-line anti-tumor necrosis factor (TNF) agents in in rheumatoid arthritis patients leads to decisions among second-line biologic agents. To better inform these decisions, the therapeutic effectiveness of...
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Effects of Homogentisic Acid and Natural Products Derived from Pinellia ternata on Secretion, Production and Gene Expression of MUC5AC Mucin from Cultured Airway Epithelial Cells

Lee HJ, Lee CJ

In this study, we investigated whether adenosine, adenine, uridine and homogentisic acid derived from Pinellia ternata affect the secretion, production and gene expression of MUC5AC mucin from airway epithelial cells....
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Biologics for the treatment of pyoderma gangrenosum in ulcerative colitis

Arivarasan K, Bhardwaj V, Sud S, Sachdeva S, Puri AS

Pyoderma gangrenosum (PG) is an uncommon extra-intestinal manifestation of inflammatory bowel disease (IBD). Despite limited published literature, biologics have caused a paradigm shift in the management of this difficult-to-treat skin...
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Natural Products for Chemoprevention of Breast Cancer

Ko EY, Moon A

Breast cancer is the primary cause of cancer death in women. Although current therapies have shown some promise against breast cancer, there is still no effective cure for the majority...
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The use of biologics for severe psoriasis

Youn SW

Psoriasis is a life-long chronic relapsing dermatosis that shows waxing and waning of disease despite of a lot of conventional treatment. Severe psoriasis, usually defined by a psoriasis area and...
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Effects of Morus alba L. and Natural Products Including Morusin on In Vivo Secretion and In Vitro Production of Airway MUC5AC Mucin

Lee HJ, Ryu J, Park SH, Woo ER, Kim AR, Lee SK, Kim YS, Kim JO, Hong JH, Lee CJ

BACKGROUND: It is valuable to find the potential activity of regulating the excessive mucin secretion by the compounds derived from various medicinal plants. We investigated whether aqueous extract of the...
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Effects of Proinflammatory Cytokines and Natural Products on Mucin Release from Cultured Hamster Tracheal Surface Epithelial Cells

Park JS, Kim HS, Seok JH, Hur GM, Park JS, Seo UK, Lee CJ

  • KMID: 1611491
  • Korean J Physiol Pharmacol.
  • 2004 Dec;8(6):329-333.
In this study, we investigated whether TNF-alpha, IL-1beta, CTMA (carboxymethyl trimethylammonium) and LPD (Lup-20[29]-ene-3beta, 28-diol) affect mucin release from airway goblet cells and compared the activities of these agents with...
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Evaluation of Limit of Detection and Range of Quantitation for RT-PCR, Real-Time RT-PCR and RT-PCR-ELISA Detection of Bovine Viral Diarrhoea Virus Contamination in Biologics Derived from Cell Cultures

Ryu SR, Shin JH, Baek SY, Kim JO, Min KI, Min BS, Kim BG, Kim DK, Park MK, Ahn MJ, Chae KS, Jeong HS, Lee SH, Park SN

  • KMID: 1515658
  • J Bacteriol Virol.
  • 2003 Jun;33(2):161-168.
Risk of viral contamination is one of major concerns common to all biologics derived from cultivated cells. Bovine viral diarrhoea virus (BVDV) has widely been known as a contaminant of...
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Effects of Extracts of Natural Products on Alkaline Phosphatase Activity of MC3T3-E1 Cells

Park SK, Kim DK, You SH, Kim HA, Kim MD, You HK, Shin HS

Several growth factors and polypeptides were studied for the regeneration of periodontal supporting tissues which had been lost due to periodontal disease. But these are not commonly used for regenerators...
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Alpha-2 Adrenoceptor Binding Profile of Natural Products Used to Treat Psychotic illnesses

Chung IW, Ahn JS, Lee HS, Park JB, Kim YS

  • KMID: 2287012
  • Korean J Psychopharmacol.
  • 1999 Apr;10(1):50-56.
Natural products have long been major sources of pharmaceutical products in medicine. We have undertaken a series of studies designed to characterize the pharmacologic profiles of natural products used to...
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Dopamine-2 and serotonin-2 receptor bindings in antipsychotic medicines from natural products

Chung IW, Kim SR, Kim EG

  • KMID: 2197828
  • J Korean Neuropsychiatr Assoc.
  • 1992 Sep;31(5):856-868.
No abstract available.
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