Allergy Asthma Immunol Res.  2020 Jan;12(1):24-41. 10.4168/aair.2020.12.1.24.

Critical Points on the Use of Biologicals in Allergic Diseases and Asthma

• Agache I
• Cojanu C
• Laculiceanu A
• Rogozea L

• KMID: 2462570
• DOI: http://doi.org/10.4168/aair.2020.12.1.24

Abstract

Improved understanding of the contribution of immune-inflammatory mechanisms in allergic diseases and asthma has encouraged development of biologicals and small molecules specifically targeting the innate and adaptive immune response. There are several critical points impacting the efficacy of this stratified approach, from the complexity of disease endotypes to the effectiveness in real-world settings. We discuss here how these barriers can be overcome to facilitate the development of implementation science for allergic diseases and asthma.

Keyword

Biological products; phenotype, precision medicine; hypersensitivity; asthma

MeSH Terms

Adaptive Immunity
Asthma*
Biological Products
Hypersensitivity
Biological Products

Figure

• 

  Figure Targeted interventions in allergic diseases and asthma. AD, atopic dermatitis; CRSwNP, chronic rhinosinusitis with nasal polyps; EoE, eosinophilic esophagitis; FA, food allergy; HES, hypereosinophilic syndrome; Ig, immunoglobulin; IL, interleukin; IL-4Rα, interleukin-4 receptor α chain; JAK, Janus-activated kinase; OIT, oral immunotherapy; STAT, signal transducer and activator of transcription; TSLP, thymic stromal lymphopoietin.

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