Korean J Gastroenterol.  2018 Apr;71(4):192-195. 10.4166/kjg.2018.71.4.192.

Comparison of Treatment Guidelines for Ulcerative Colitis: Role of Biologics

• Bae JH
• Yang DH

• KMID: 2409887
• DOI: http://doi.org/10.4166/kjg.2018.71.4.192

Abstract

Ulcerative colitis (UC) is a chronic inflammatory condition of the colon, characterized by diffuse mucosal inflammation with bloody diarrhea. The therapeutic goals in UC have evolved from symptomatic relief to deep remission, including sustained steroid-free clinical remission, mucosal healing, and ideally histologic remission. The management of UC has significantly been improved by advance of biologic agents including anti-tumor necrosis factor alpha (TNF-α) antibodies. Anti-TNF-α agent have progressively been introduced earlier in treatment algorithms for UC in order to minimize steroid exposure and dependence and to maximize disease control and quality of life. We reviewed the therapeutic recommendations of biologic agents for UC in the Korean and European Crohn's and Colitis Organization guidelines.

Keyword

Ulcerative colitis; Tumor necrosis factor-alpha; Biological products

MeSH Terms

Antibodies
Biological Factors
Biological Products*
Colitis
Colitis, Ulcerative*
Colon
Diarrhea
Inflammation
Necrosis
Quality of Life
Tumor Necrosis Factor-alpha
Ulcer*
Antibodies
Biological Factors
Biological Products
Tumor Necrosis Factor-alpha

Reference

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