1. Cassebaum H. News of the discovery of acids in organic material by C.W. Scheele (author's transl). Pharmazie. 1981; 36:135–138. PMID:
7015369.
2. Hamilton GR, Baskett TF. In the arms of Morpheus the development of morphine for postoperative pain relief. Can J Anaesth. 2000; 47:367–374. PMID:
10764185.
Article
3. Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981-2002. J Nat Prod. 2003; 66:1022–1037. PMID:
12880330.
Article
4. Itokawa H, Morris-Natschke SL, Akiyama T, Lee KH. Plant-derived natural product research aimed at new drug discovery. J Nat Med. 2008; 62:263–280. PMID:
18425692.
Article
5. Hur SJ, Kang SH, Jung HS, et al. Review of natural products actions on cytokines in inflammatory bowel disease. Nutr Res. 2012; 32:801–816. PMID:
23176791.
Article
6. Ng SC, Lam YT, Tsoi KK, Chan FK, Sung JJ, Wu JC. Systematic review: the efficacy of herbal therapy in inflammatory bowel disease. Aliment Pharmacol Ther. 2013; 38:854–863. PMID:
23981095.
Article
7. Langmead L, Chitnis M, Rampton DS. Use of complementary therapies by patients with IBD may indicate psychosocial distress. Inflamm Bowel Dis. 2002; 8:174–179. PMID:
11979137.
Article
8. Langmead L, Makins RJ, Rampton DS. Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Aliment Pharmacol Ther. 2004; 19:521–527. PMID:
14987320.
Article
9. Dahmen U, Gu YL, Dirsch O, et al. Boswellic acid, a potent anti-inflammatory drug, inhibits rejection to the same extent as high dose steroids. Transplant Proc. 2001; 33:539–541. PMID:
11266947.
Article
10. Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med. 2001; 67:391–395. PMID:
11488449.
Article
11. Singh S, Khajuria A, Taneja SC, Johri RK, Singh J, Qazi GN. Boswellic acids: A leukotriene inhibitor also effective through topical application in inflammatory disorders. Phytomedicine. 2008; 15:400–407. PMID:
18222672.
Article
12. Krieglstein CF, Anthoni C, Rijcken EJ, et al. Acetyl-11-keto-beta-boswellic acid, a constituent of a herbal medicine from Boswellia serrata resin, attenuates experimental ileitis. Int J Colorectal Dis. 2001; 16:88–95. PMID:
11355324.
Article
13. Kudo T, Okamura S, Zhang Y, Masuo T, Mori M. Topical application of glycyrrhizin preparation ameliorates experimentally induced colitis in rats. World J Gastroenterol. 2011; 17:2223–2228. PMID:
21633533.
Article
14. Yuan H, Ji WS, Wu KX, Jiao JX, Sun LH, Feng YT. Anti-inflammatory effect of Diammonium Glycyrrhizinate in a rat model of ulcerative colitis. World J Gastroenterol. 2006; 12:4578–4581. PMID:
16874877.
Article
15. Langmead L, Dawson C, Hawkins C, Banna N, Loo S, Rampton DS. Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an
in vitro study. Aliment Pharmacol Ther. 2002; 16:197–205. PMID:
11860402.
Article
16. Langmead L, Rampton DS. Review article: complementary and alternative therapies for inflammatory bowel disease. Aliment Pharmacol Ther. 2006; 23:341–349. PMID:
16422993.
Article
17. Subbotina MD, Timchenko VN, Vorobyov MM, Konunova YS, Aleksandrovih YS, Shushunov S. Effect of oral administration of tormentil root extract (Potentilla tormentilla) on rotavirus diarrhea in children: a randomized, double blind, controlled trial. Pediatr Infect Dis J. 2003; 22:706–711. PMID:
12913771.
Article
18. Huber R, Ditfurth AV, Amann F, et al. Tormentil for active ulcerative colitis: an open-label, dose-escalating study. J Clin Gastroenterol. 2007; 41:834–838. PMID:
17881930.
19. Ben-Arye E, Goldin E, Wengrower D, Stamper A, Kohn R, Berry E. Wheat grass juice in the treatment of active distal ulcerative colitis: a randomized double-blind placebo-controlled trial. Scand J Gastroenterol. 2002; 37:444–449. PMID:
11989836.
Article
20. Ali T, Shakir F, Morton J. Curcumin and inflammatory bowel disease: biological mechanisms and clinical implication. Digestion. 2012; 85:249–255. PMID:
22950087.
Article
21. Cuendet M, Pezzuto JM. The role of cyclooxygenase and lipoxygenase in cancer chemoprevention. Drug Metabol Drug Interact. 2000; 17:109–157. PMID:
11201293.
Article
22. Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci. 2005; 50:2191–2193. PMID:
16240238.
Article
23. Hanai H, Iida T, Takeuchi K, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006; 4:1502–1506. PMID:
17101300.
Article
24. Lim BO. Coriolus versicolor suppresses inflammatory bowel disease by Inhibiting the expression of STAT1 and STAT6 associated with IFN-gamma and IL-4 expression. Phytother Res. 2011; 25:1257–1261. PMID:
21796702.
Article
25. Wasser SP, Weis AL. Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol. 1999; 19:65–96. PMID:
9987601.
Article
26. Kim YO, Park HW, Kim JH, Lee JY, Moon SH, Shin CS. Anticancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus. Life Sci. 2006; 79:72–80. PMID:
16458328.
Article
27. Mishra SK, Kang JH, Kim DK, Oh SH, Kim MK. Orally administered aqueous extract of Inonotus obliquus ameliorates acute inflammation in dextran sulfate sodium (DSS)-induced colitis in mice. J Ethnopharmacol. 2012; 143:524–532. PMID:
22819687.
Article
28. Debnath T, Kim da H, Lim BO. Natural products as a source of anti-inflammatory agents associated with inflammatory bowel disease. Molecules. 2013; 18:7253–7270. PMID:
23783459.
Article
29. Liu L, Yuan S, Sun Y, et al. The possible mechanisms of Fructus Mume pill in the treatment of colitis induced by 2,4,6-trinitrobenzene sulfonic acid in rats. J Ethnopharmacol. 2009; 126:557–564. PMID:
19703546.
Article
30. Jin HL, Lee BR, Lim KJ, Debnath T, Shin HM, Lim BO. Anti-inflammatory effects of Prunus mume mixture in colitis induced by dextran sodium sulfate. Korean J Med Crop Sci. 2011; 19:16–23.
Article
31. Chen Y, Zhang H, Li YX, et al. Crocin and geniposide profiles and radical scavenging activity of gardenia fruits (Gardenia jasminoides Ellis) from different cultivars and at the various stages of maturation. Fitoterapia. 2010; 81:269–273. PMID:
19815056.
Article
32. Oh PS, Lim KT. Plant originated glycoprotein has anti-oxidative and anti-inflammatory effects on dextran sulfate sodium-induced colitis in mouse. J Biomed Sci. 2006; 13:549–560. PMID:
16586048.
Article
33. Hsiang CY, Lo HY, Huang HC, Li CC, Wu SL, Ho TY. Ginger extract and zingerone ameliorated trinitrobenzene sulphonic acid-induced colitis in mice via modulation of nuclear factor-kappaB activity and interleukin-1beta signalling pathway. Food Chem. 2013; 136:170–177. PMID:
23017409.
Article
34. dos Reis SB, de Oliveira CC, Acedo SC, et al. Attenuation of colitis injury in rats using
Garcinia cambogia extract. Phytother Res. 2009; 23:324–329. PMID:
18979524.
35. Dryden GW, Song M, McClain C. Polyphenols and gastrointestinal diseases. Curr Opin Gastroenterol. 2006; 22:165–170. PMID:
16462174.
Article
36. Yang F, Oz HS, Barve S, de Villiers WJ, McClain CJ, Varilek GW. The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6. Mol Pharmacol. 2001; 60:528–533. PMID:
11502884.
37. Ran ZH, Chen C, Xiao SD. Epigallocatechin-3-gallate ameliorates rats colitis induced by acetic acid. Biomed Pharmacother. 2008; 62:189–196. PMID:
18325726.
Article
38. Abboud PA, Hake PW, Burroughs TJ, et al. Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis. Eur J Pharmacol. 2008; 579:411–417. PMID:
18022615.
Article
39. Cruz T, Galvez J, Ocete MA, Crespo ME, Sanchez de Medina LHF, Zarzuelo A. Oral administration of rutoside can ameliorate inflammatory bowel disease in rats. Life Sci. 1998; 62:687–695. PMID:
9472728.
Article
40. Galvez J, Cruz T, Crespo E, et al. Rutoside as mucosal protective in acetic acid-induced rat colitis. Planta Med. 1997; 63:409–414. PMID:
9342943.
Article
41. Kwon KH, Murakami A, Tanaka T, Ohigashi H. Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression. Biochem Pharmacol. 2005; 69:395–406. PMID:
15652231.
Article
42. Burke MD, Berger EM, Schreiber SL. A synthesis strategy yielding skeletally diverse small molecules combinatorially. J Am Chem Soc. 2004; 126:14095–14104. PMID:
15506774.
Article
43. Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci. 2005; 78:431–441. PMID:
16198377.
Article
44. Mishra BB, Tiwari VK. Natural products: an evolving role in future drug discovery. Eur J Med Chem. 2011; 46:4769–4807. PMID:
21889825.
Article
45. Michel T, Halabalaki M, Skaltsounis AL. New concepts, experimental approaches, and dereplication strategies for the discovery of novel phytoestrogens from natural sources. Planta Med. 2013; 79:514–532. PMID:
23479392.
Article
46. Hsieh PW, Hung CF, Fang JY. Current prodrug design for drug discovery. Curr Pharm Des. 2009; 15:2236–2250. PMID:
19601825.
Article
47. Reichert JM. Trends in development and approval times for new therapeutics in the United States. Nat Rev Drug Discov. 2003; 2:695–702. PMID:
12951576.
Article
48. Descotes J. Immunotoxicology: role in the safety assessment of drugs. Drug Saf. 2005; 28:127–136. PMID:
15691223.
49. Potterat O, Hamburger M. Drug discovery and development with plant-derived compounds. Prog Drug Res. 2008; 65:4547–118. PMID:
18084913.
Article
50. Dickson M, Gagnon JP. Key factors in the rising cost of new drug discovery and development. Nat Rev Drug Discov. 2004; 3:417–429. PMID:
15136789.
Article