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Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart

Okada JI, Washio T, Sugiura S, Hisada T

A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce all the fundamental activities of the working heart, including propagation of excitation, contraction, and...
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Potency and plasma protein binding of drugs in vitro—a potentially misleading pair for predicting in vivo efficacious concentrations in humans

Yim DS

In drug discovery or preclinical stages of development, potency parameters such as ICâ‚…â‚€, K(i), or K(d) in vitro have been routinely used to predict the parameters of efficacious exposure (AUC,...
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Clinical and genetic aspects of Charcot-Marie-Tooth disease subtypes

Nam SH, Choi BO

Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neuropathies and is both genetically and clinically heterogeneous, with variable inheritance modes. With regard to clinical and genetic aspects, CMT...
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Epilepsy Surgery in 2019: A Time to Change

Phi JH, Cho BK

Epilepsy has been known to humankind since antiquity. The surgical treatment of epilepsy began in the early days of neurosurgery and has developed greatly. Many surgical procedures have stood the...
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Guanabenz Acetate Induces Endoplasmic Reticulum Stress–Related Cell Death in Hepatocellular Carcinoma Cells

Kang HJ, Seol HS, Lee SE, Suh YA, Kim J, Jang SJ, Yu E

BACKGROUND: Development of chemotherapeutics for the treatment of advanced hepatocellular carcinoma (HCC) has been lagging. Screening of candidate therapeutic agents by using patient-derived preclinical models may facilitate drug discovery for...
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The Role of medical doctor in the era of artificial intelligence

Seo JB

Recent advances in new technologies such as artificial intelligence, big data, and virtual reality have led to significant innovations in various industries. Artificial intelligence, particularly in applications using deep learning...
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Selectins: functional importance as cell adhesion molecule in immune system

Noh Y, Cho D, Ko H, Lim D, Chai HH

Selectins are cell membrane glycoproteins that recognize specific glycoconjugates expressed on the surface of cells. Then, selectins adjust cell-cell interactions that are important in inflammation, hemostasis and cancer metastasis. Selectins...
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A review of three years' experience of the first pharmacometrics company in Korea

Lee SJ, Jeon S

As the pharmaceutical industry in Korea is reaching the golden era of drug discovery due to increased investments in research and development and government funds, the need for a more...
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An integrated review on new targets in the treatment of neuropathic pain

Khangura R, Sharma J, Bali A, Singh N, Jaggi AS

Neuropathic pain is a complex chronic pain state caused by the dysfunction of somatosensory nervous system, and it affects the millions of people worldwide. At present, there are very few...
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Diagnosing Diabetic Neuropathy: Something Old, Something New

Petropoulos IN, Ponirakis , Khan A, Almuhannadi H, Gad H, Malik RA

There are potentially many ways of assessing diabetic peripheral neuropathy (DPN). However, they do not fulfill U.S. Food and Drug Administration (FDA) requirements in relation to their capacity to assess...
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Natural radioprotectors and their impact on cancer drug discovery

Kuruba V, Gollapalli P

Cancer is a complex multifaceted illness that affects different patients in discrete ways. For a number of cancers the use of chemotherapy has become standard practice. Chemotherapy is a use...
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Advanced tube formation assay using human endothelial colony forming cells for in vitro evaluation of angiogenesis

Lee H, Kang KT

The tube formation assay is a widely used in vitro experiment model to evaluate angiogenic properties by measuring the formation of tubular structures from vascular endothelial cells (ECs). in vitro...
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iPSC Modeling of Presenilin1 Mutation in Alzheimer's Disease with Cerebellar Ataxia

Li L, Roh JH, Chang EH, Lee Y, Lee S, Kim M, Koh W, Chang JW, Kim HJ, Nakanishi , Barker RA, Na DL, Song J

Disease modeling of Alzheimer's disease (AD) has been hampered by the lack of suitable cellular models while animal models are mainly based on the overexpression of AD-related genes which often...
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From Bench to Market: Preparing Human Pluripotent Stem Cells Derived Cardiomyocytes for Various Applications

Moon SH, Bae D, Jung TH, Chung EB, Jeong YH, Park SJ, Chung HM

Human cardiomyocytes (CMs) cease to proliferate and remain terminally differentiated thereafter, when humans reach the mid-20s. Thus, any damages sustained by myocardium tissue are irreversible, and they require medical interventions...
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Discovery of a New DNA Gyrase A Inhibitor, 4-[(1-methyl-6-nitroquinolin-1-ium-4-yl)amino]-N-[4-[(1-methylpyridin-1-ium-4-yl)amino]phenyl]benzamide

Seo I, Suh SI, Suh MH, Baek WK

Escherichia coli (E. coli) is a clinically important causative organism that can lead to urinary tract infections. Quinolone antibiotics are among the first-line treatments for urinary tract infections. However, the...
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Dielectrophoretic force measurement of red blood cells exposed to oxidative stress using optical tweezers and a microfluidic chip

Jeon HJ, Lee H, Yoon DS, Kim BM

Red blood cell (RBC) dysfunction is often associated with a pathological intervention, and it has been proposed as a critical risk factor for certain lethal diseases. Examining the cell viability...
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Prediction of pharmacokinetics and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach: A case study of caffeine and ciprofloxacin

Park MH, Shin SH, Byeon JJ, Lee GH, Yu BY, Shin YG

Over the last decade, physiologically based pharmacokinetics (PBPK) application has been extended significantly not only to predicting preclinical/human PK but also to evaluating the drug-drug interaction (DDI) liability at the...
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Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery

Park SJ, Im DS

Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G...
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Effect of β-carotene on Cell Growth Inhibition of KB Human Oral Cancer Cells

Yang SS, Kim SG, Park BS, Go DS, Yu SK, Kim CS, Kim J, Kim DK

β-carotene is present in carrots, pumpkins, and sweet potatoes. It suppresses many types of cancers by regulating cellular proliferation and apoptosis through a variety of mechanisms. However, the effects of...
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Sequence Analysis of Hypothetical Proteins from Helicobacter pylori 26695 to Identify Potential Virulence Factors

Naqvi AA, Anjum F, Khan FI, Islam A, Ahmad F, Hassan MI

Helicobacter pylori is a Gram-negative bacteria that is responsible for gastritis in human. Its spiral flagellated body helps in locomotion and colonization in the host environment. It is capable of...
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