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Multiplex PCR for Rapid Detection of Genes Encoding Class A Carbapenemases

Hong SS, Kim K, Huh JY, Jung B, Kang MS, Hong SG

In recent years, there have been increasing reports of KPC-producing Klebsiella pneumoniae in Korea. The modified Hodge test can be used as a phenotypic screening test for class A carbapenamase...
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AbaR7, a Genomic Resistance Island Found in Multidrug-resistant Acinetobacter baumannii Isolates in Daejeon, Korea

Sung JY, Koo SH, Cho HH, Kwon KC

BACKGROUND: Acinetobacter baumannii resistance islands (AbaRs) have been recently recognized as mobile genetic elements that harbor multiple resistance determinants and are associated with multidrug resistance (MDR). In the present study,...
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New Decision Criteria for Selecting Delta Check Methods Based on the Ratio of the Delta Difference to the Width of the Reference Range Can Be Generally Applicable for Each Clinical Chemistry Test Item

Park SH, Kim SY, Lee W, Chun S, Min WK

BACKGROUND: Many laboratories use 4 delta check methods: delta difference, delta percent change, rate difference, and rate percent change. However, guidelines regarding decision criteria for selecting delta check methods have...
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Evaluation of the Xpert Clostridium difficile Assay for the Diagnosis of Clostridium difficile Infection

Shin S, Kim M, Kim M, Lim H, Kim H, Lee K, Chong Y

Infection with Clostridium difficile is a growing concern because of the increasing prevalence and spread of nosocomial infections. Emergence of the hypervirulent 027/NAP1/BI strain is also notable. Existing diagnostic methods...
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Detection of RUNX1-MECOM Fusion Gene and t(3;21) in a Very Elderly Patient Having Acute Myeloid Leukemia with Myelodysplasia-Related Changes

Yang JJ, Cho SY, Suh JT, Lee HJ, Lee WI, Yoon HJ, Baek SK, Park TS

An 87-yr-old woman was diagnosed with AML with myelodysplasia-related changes (AML-MRC). The initial complete blood count showed Hb level of 5.9 g/dL, platelet counts of 27x10(9)/L, and white blood cell...
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First Korean Case of Robinsoniella peoriensis Bacteremia in a Patient with Aspiration Pneumonia

Jeon Y, Kim TS, Kim HB, Park KU, Song J, Kim EC

Robinsoniella peoriensis has recently been identified as a Gram-positive, spore-forming, anaerobic rod originally recovered from swine manure storage pits. To date, 6 cases of R. peoriensis infection have been reported,...
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Molecular Identification of Schizophyllum commune as a Cause of Allergic Fungal Sinusitis

Won EJ, Shin JH, Lim SC, Shin MG, Suh SP, Ryang DW

Schizophyllum commune, a basidiomycetous fungus, rarely causes disease in humans. We report a rare case of allergic fungal sinusitis caused by S. commune in a 14-yr-old girl. The patient presented...
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Analysis of Acid Sphingomyelinase Activity in Dried Blood Spots Using Tandem Mass Spectrometry

Legnini E, Orsini JJ, Muhl A, Johnson B, Dajnoki A, Bodamer OA

BACKGROUND: Niemann Pick disease (NP) is a rare, lysosomal storage disorder due to deficiency of the intra-lysosomal enzyme acid sphingomyelinase (ASM) resulting in intracellular accumulation of sphingomyelin. We evaluated a...
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Changes in the Levels of Interleukins 6, 8, and 10, Tumor Necrosis Factor Alpha, and Granulocyte-colony Stimulating Factor in Korean Burn Patients: Relation to Burn Size and Postburn Time

Kim HS, Kim JH, Yim H, Kim D

BACKGROUND: Major burn injury induces an inflammatory response that is accompanied by the release of various cytokines. We investigated the gradual changes in the levels of pro-inflammatory and anti-inflammatory cytokines...
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A Case Report of Fanconi Anemia Diagnosed by Genetic Testing Followed by Prenatal Diagnosis

Lee HJ, Park S, Kang HJ, Jun JK, Lee JA, Lee DS, Park SS, Seong MW

Fanconi anemia (FA) is a rare genetic disorder affecting multiple body systems. Genetic testing, including prenatal testing, is a prerequisite for the diagnosis of many clinical conditions. However, genetic testing...
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Clinical Usefulness of Cell-based Indirect Immunofluorescence Assay for the Detection of Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum Disorder

Kang ES, Min JH, Lee KH, Kim BJ

BACKGROUND: The presence of antibodies to aquaporin-4 (AQP4) has been identified as a key characteristic of neuromyelitis optica spectrum disorder (NMOSD), an autoimmune inflammatory demyelinating central nervous system (CNS) disorder....
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Quinolone-resistant Shigella flexneri Isolated in a Patient Who Travelled to India

Jeon YL, Nam YS, Lim G, Cho SY, Kim YT, Jang JH, Kim J, Park M, Lee HJ

We report a recent case in which ciprofloxacin-resistant Shigella flexneri was isolated from a 23-yr-old female patient with a history of travel to India. Prior to her admission to our...
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