J Korean Med Sci.
2003 Aug;18(4):501-504. 10.3346/jkms.2003.18.4.501.
A Single Nucleotide Polymorphism in the E-cadherin Gene Promoter-160 is Not Associated with Risk of Korean Gastric Cancer
- Affiliations
-
- 1Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea. stingray@catholic.ac.kr
- 2Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 3Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- KMID: 648900
- DOI: http://doi.org/10.3346/jkms.2003.18.4.501
Abstract
- Recently, the -160 C/A polymorphism, located within the regulatory region of E-cadherin promoter, has been shown to influence E-cadherin transcription by altering transcription factor binding. We examined the effect of this polymorphism on risk of gastric cancer and on histological classification of intestinal- and diffuse-type gastric cancer in 146 normal healthy individuals and 292 Korean gastric cancer patients. Genomic DNA samples were examined by polymerase chain reaction (PCR)-single strand conformational polymorphism (SSCP)-sequencing and confirmed by restriction fragment length polymorphism (RFLP). Unexpectedly, there was no significant difference in the genotype frequencies of the polymorphism between normal control and gastric cancer patients (x(2) test, p=0.433). The estimated odd ratio of C/C to A/A genotype in gastric cancer cases was 1.07 (95% confidence interval, 0.396-2.870). We also found no evidence for differences in risk for the intestinal- and diffuse-type gastric cancer. These results suggest that the -160 C/A polymorphism of the E-cadherin has no direct effect on the risk of Korean gastric cancer development and on its histological classification.
MeSH Terms
-
Alleles
Cadherins/*genetics
DNA/metabolism
Genetic Predisposition to Disease
Genotype
Homozygote
Human
Korea
Odds Ratio
Polymerase Chain Reaction
Polymorphism (Genetics)
Polymorphism, Restriction Fragment Length
*Polymorphism, Single Nucleotide
Polymorphism, Single-Stranded Conformational
*Promoter Regions (Genetics)
Risk
Stomach Neoplasms/*genetics
Transcription, Genetic
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