Korean J Obstet Gynecol.  2008 Feb;51(2):158-166.

Association of the E-cadherin gene polymorphism with cervical intraepithelial neoplasm and cervical cancer in Korean population

• Kang HJ
• Moon HS
• Chung HW

Abstract

OBJECTIVE
The aim of this study was to explore the association between E-cadherin promoter -160C>A polymorphism and the risk of cervical cancer and cervical intraepithelial neoplasm (CIN) in a Korean population.
METHODS
We investigate 107 patients with histopathologically confirmed cervical cancer, 119 patients with histopathologically confirmed CIN and 112 control group women who were surgically proven to have normal cervices. The genetic distribution of E-cadherin promoter -160C>A polymorphism were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products.
RESULTS
We found no overall association between each individual E-cadherin promoter -160C>A genotype and the risk of cervical cancer and CIN. In the cervical cancer group, the allele frequency of C was 83.6%, in the control group 83.5%, showing no significant difference (p=0.941). Similarly, in the CIN group, the allele frequency of C was 81.9%, in the control group 83.5%, showing no significant difference (p=0.645). A subgroup analysis of the clinical parameters in CC, CA, AA genotype also showed no significant difference suggesting the lack of an association between E-cadherin promoter -160C>A polymorphism and cervix cancer stages (p=0.413), then its polymorphism and HPV infection (p=0.634).
CONCLUSION
our results show that Korean women with specific polymorphism in E-cadherin promoter -160C>A are neither more susceptible to develop the cervical cancer or CIN nor more valuable for the cancer progression.

Keyword

E-cadherin promoter; -160C>A Polymorphism; Cervical cancer; Cervical intraepithelial neoplasm (CIN)

MeSH Terms

Cadherins
Cervical Intraepithelial Neoplasia
Female
Gene Frequency
Genotype
Humans
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Uterine Cervical Neoplasms
Cadherins