Korean J Gynecol Oncol Colposc.
2001 Dec;12(4):318-324.
The Clinical Significance of Interleukin-6 Promoter Polymorphism in Cervical Cancer
- Affiliations
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- 1Department of Obstetrics & Gynecology, College of Medicine, Ewha Womans Univercity, and Medical Research Center.
- 2Department of Biochemistry, College of Medicine, Ewha Womans Univercity, and Medical Research Center.
Abstract
OBJECTIVE
The aims of this study were to determine whether polymorphisms of the interleukin-6 promoter might be associated with an increased risk of cervical cancer.
METHODS
The bloods were obtained from healthy women(n=130), and patients with cervical cancer(n=109). The IL- 6 promoter was examined with allele-specific PCR method. The clinical characteristics of patients were compared between two groups.
RESULTS
There is IL-6-572 SNP. The genotypic distribution in cervical cancer patients were GG genotype 55(50.5%), GC genotype 45(41.3%), CC genotype 9(8.2%). There were no stastistical differences of each genotypes between control group and cervical cancer group. (p>0.05)
CONCLUSION
Our results suggested that SNP of IL-6 promoter is not related with the carcinogenesis of cervical cancer.
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