Pediatr Allergy Respir Dis.  2005 Jun;15(2):126-132.

Association Between IL-13 Polymorphism (-1512A/C) and Atopic Dermatitis in Korean Children

• Kim KW
• Kang MJ
• Kim HB
• Lee SY
• Kim NC
• Jang SO
• Hong SJ

Abstract

PURPOSE
Interleukin (IL) -13 plays a pivotal role in the induction of immunoglobulin E (IgE) and in the pathogenesis of atopic dermatitis (AD). Recently, an association was reported between the polymorphism of the IL-13 promoter region (-1512A/C) and atopic asthma. We investigated the association between the IL-13 single nucleotide polymorphism (SNP) in the promoter region (-1512A/C) and atopic dermatitis in Korean children with AD. METHODS: We enrolled 204 allergic AD, 92 non-allergic AD, and 116 non-atopic healthy children. Evaluated phenotypes of atopic dermatitis included total IgE, total eosinophil count, and eosinophil fraction. We used a PCR-RFLP method to identify IL-13 genotypes. RESULTS: The allele frequencies of the IL-13 promoter polymorphism (-1512A/C) did not differ statistically among the three groups. Children with one or two copies of risk alleles in the promoter region (-1512C) did not show any significant association with the clinical phenotypes of atopic dermatitis including total IgE, eosinophil phenotypes and SCORAD score in the allergic or non-allergic atopic dermatitis. CONCLUSION: These data suggest that the -1512A/C polymorphism of IL-13 gene may not be associated with neither the development nor the clinical phenotypes of atopic dermatitis in Korean children.

Keyword

Atopic dermatitis; Interleukin-13; Promoter; Polymorphism

MeSH Terms

Alleles
Asthma
Child*
Dermatitis, Atopic*
Eosinophils
Gene Frequency
Genotype
Humans
Immunoglobulin E
Immunoglobulins
Interleukin-13*
Interleukins
Phenotype
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Immunoglobulin E
Immunoglobulins
Interleukin-13
Interleukins